Heart rhythm (HR), and blood pressure (SBP, DBP) was registered at a group of practically healthy workers with a normal operating mode (51 persons) and machinists of locomotive brigades with replaceable operating mode (200), and also at oncological patients (23). The statistical importance of primary factors of regress and correlation between the investigated functions in all examined groups, as a mutual coordination in orientation of these changes (their conjugacy) was estimated. Desinchronosis of blood circulation have been found both in oncological patients and in machinists of locomotive brigades.