СОСТАВ МИКРОБИОТЫ КИШЕЧНИКА У ОТНОСИТЕЛЬНО ЗДОРОВЫХ ЖИТЕЛЕЙ МОСКВЫ И МОСКОВСКОЙ ОБЛАСТИ С ОЖИРЕНИЕМ

Purpose of the study. To study the association between the gut microbiota composition and body mass index and abdominal obesity in participants without clinical chronic diseases. Materials and methods. The study included 92 residents from Moscow and the Moscow region, men and women aged 25 to 76 years without clinical chronic non-communicable diseases are not receiving medication, but with the possible presence of cardiovascular risk factors, including obesity. All participants underwent a thorough preliminary examination, including physical examination, clinical and biochemical blood tests, electrocardiography, treadmill test, evaluation of the presence of the cardiovascular risk factors, as well as the sequencing of the variable regions of the V3-V4 16S rRNA gene of the gut microbiota and diet analysis. Results. The study revealed that opportunistic bacteria of the genera Serratia and Prevotella were largely represented in overweight patients and / or patients with abdominal obesity. Amylolytic bacteria of the genus Oscillosipa were less represented in individuals with abdominal obesity. Probiotic bacteria of the genus Bifidobacterium producing SCFA were significantly less represented in people who consumed a lot of cholesterol or ethanol. Conclusion. Gut microbiota imbalance with an increase in opportunistic bacteria level and a decrease in strictly anaerobic amylolytic bacteria is associated with obesity.