Whether polycyclic aromatic hydrocarbons (PAHs) exposure is associated with muscle mass and muscle strength has been scantly investigated. The cross-sectional associations of urinary PAH metabolites with appendicular skeletal muscle mass and hand grip strength in adults were first investigated in the National Health and Nutrition Examination Survey (NHANES). Laboratory study was further carried out to examine the effect of PAHs on skeletal muscle mass and strength. 2742 and 2462 US adults were finally analyzed for muscle mass and muscle strength, respectively. In male participants, urinary PAH metabolites were found to show an inverse relationship with muscle mass and grip strength. In female participants, no significant relationship was found between urinary PAH metabolites with muscle mass or grip strength. In male Sprague-Dawley (SD) rats, administration of B [a]P induced muscle atrophy when compared with the control. However, muscle mass and strength were not significantly altered in female rats. The variations in muscle morphology parameters were accompanied by significant decrease in plasma testosterone levels in the B [a]P-treated male rats. Testosterone co-treatment significantly mitigated B [a]P mediated damages in skeletal muscle in male rats. The results of the present study indicate that there may be a gender-specific causal relationship between the PAHs and muscle atrophy.

Background: Accumulating evidence from observational studies suggested that circulating adiponectin levels are associated with the risk of rheumatoid arthritis (RA), but the causality remains unknown. We aimed to assess the causal relationship of adiponectin with RA risk.Methods: Based on summary statistics from large-scale genome-wide association studies (GWAS), we quantified the genetic correlation between adiponectin and RA. Then bidirectional Mendelian randomization (MR) analysis was performed to assess the causal relationship. Twenty single-nucleotide polymorphisms (SNPs) associated with adiponectin were selected as instrumental variables from a recent GWAS (n = 67,739). We applied theses SNPs to a large-scale GWAS for RA (14,361 cases and 43,923 controls) with replication using RA data from the FinnGen consortium (6,236 cases and 147,221 controls) and the UK Biobank (5,201 cases and 457,732 controls). The inverse-variance weighted (IVW) and multiple pleiotropy-robust methods were used for two-sample MR analyses.Results: Our analyses showed no significant genetic correlation between circulating adiponectin levels and RA [rG = 0.127, 95% confidence interval (CI): –0.012 to 0.266, P = 0.074]. In MR analyses, genetically predicted adiponectin levels were not significantly associated with the RA risk (odds ratio: 0.98, 95% CI: 0.88–1.09, P = 0.669). In the reverse direction analysis, there is little evidence supporting an association of genetic susceptibility to RA with adiponectin (β: 0.007, 95% CI: –0.003 to 0.018, P = 0.177). Replication analyses and sensitivity analyses using different models yielded consistent results.Conclusions: Our findings provided no evidence to support the causal effect of adiponectin levels on RA risk and of RA on circulating adiponectin levels.

TP73-AS1 is a novel antisense long noncoding RNA and plays an important role in cell proliferation and cancer development. However, the link between TP73-AS1 and colorectal cancer (CRC) has not yet been reported. To explore the association of genetic variants in TP73-AS1 and its expression with CRC susceptibility and prognosis. A case–control study (including 507 CRC cases and 503 controls) and bioinformatics analysis were conducted. rs9800 polymorphism was significantly related to higher risk in CRC [adjusted odds ratio (AOR) = 1.33, 95% confidence interval (CI) = 1.02–1.75, P = 0.034 in heterozygote codominant model]. There was no difference between TP73-AS1 polymorphisms and different tumor node metastasis (TNM) stages in the adjusted model. Moreover, TP73-AS1 expression level was positively related to different TNM stages. After adjusted for age, gender and TNM, higher TP73-AS1 expression levels were related to shorter recurrence-free survival time [hazard ratio (HR) = 1.66, 95% CI = 1.02–2.71, P = 0.043]. TP73-AS1 polymorphisms and expression may be associated with susceptibility and prognosis of CRC.

Aim:Circulating chemerin level has been reported to be higher in patients with various types of cancer. However, the conclusions obtained are not unified. The aim of present study is to draw an evidence-based conclusion on the relationship between circulating chemerin and risk of cancer.Materials & methods:A systematic search was carried out in PubMed and Web of Science up to 30 June 2019. The random-effects model was applied to calculate summary standardized mean differences with 95% CIs.Results:The meta-analysis included a total of 12 separate studies, 876 cases and 739 healthy controls. The results showed that the expression level of circulating chemerin was significantly higher in cancer patients than that in control group (pooled standardized mean difference = 1.47, 95% CI = 1.03-1.90).Conclusion:This meta-analysis concludes that a high level of circulating chemerin is strongly associated with cancer risk.

BACKGROUND:Emerging evidence has identified cardiovascular system as a potential target of Bisphenol A (BPA). Although a few studies have revealed the relationship between BPA and the risk of several cardiovascular diseases (CVD) outcomes and CVD risk factors, no published studies have investigated the link between urinary BPA and the risk of stroke. METHODS:Data were derived from the United States National Health and Nutrition Examination Surveys (NHANES), with a representative sample aged ≥20 years (n = 9139) from 2003 to 2014. We performed multivariable logistic regression model to estimate associations between quartiles and natural logarithm transformed urinary BPA concentrations and five specific CVD outcomes and total CVD. RESULTS:In quartile analysis, highest level of urinary BPA was associated with increased prevalence of myocardial infarction (MI) (OR = 1.73, 95% CI = 1.11-2.69) and stroke (OR = 1.61, 95% CI = 1.09-2.36), when compared with those at the lowest quartile. Per unit (μg/g creatinine) increment in ln-transformed BPA concentration was shown to be significantly associated with 19%, 19%, 25%, 29%, 20%, and 16% increased odds ratios of prevalence of congestive heart failure, coronary heart disease (CHD), angina pectoris, MI, stroke and total CVD among total participants, respectively. Similar associations were found in males rather than in females. CONCLUSION:We provided the premier evidence of positive relationship between urinary BPA concentration and stroke in U.S. POPULATION:Urinary BPA levels were also positively correlated with congestive heart failure, CHD, angina pectoris, MI, as well as total CVD. These associations were more evident in males. Well-coordinated and prospective studies are warranted to gain the human effects of BPA on CVD.

Background: Circulating adipokines levels have been reported to be associated with the risk of rheumatoid arthritis (RA). However, it is still unclear whether these associations are causal or biased by reverse causation or residual confounding. This study aimed to assess potential causal roles of five adipokines (namely, adiponectin, leptin, resistin, chemerin, and retinol-blinding protein 4 [RBP4]) in the occurrence of RA. Methods: We conducted a two-sample Mendelian randomization analysis to investigate these associations. We used summary-level data from genome-wide association studies (GWASs) for adipokines in individuals of European ancestry as the exposure, and a separate large-scale meta-analysis of a GWAS which included 14,361 RA cases and 43,923 controls of European ancestry as the outcome. Genetic variants were selected as instrumental variables if robustly genome-wide significant in their associations with adipokines. The causal effects were estimated using the inverse-variance weighted method in the primary analysis. Sensitivity analyses were performed to warrant that bias due to genetic pleiotropy was unlikely. Results: The circulating resistin was found to be the only adipokinetic factor having statistical significance, with higher levels causally associated with the risk of RA (odds ratio: 1.28; 95% confidence interval: [1.07, 1.53] per unit increase in the natural log-transformed resistin). In contrast, associations of adiponectin, leptin, chemerin, and RBP4 with risk of RA were not statistically significant. The MR assumptions did not seem to be violated. Sensitivity analyses yielded consistent findings. Conclusions: Genetically predicted circulating resistin levels were positively associated with RA risk. Our analysis suggested that resistin may play a notable causal role in RA pathogenesis. It would be beneficial for the development of clinical as well as public health strategies that target appropriate levels of resistin for future RA intervention.

Objective: The majority of the published studies ascertaining the relationships between low bone mineral density (BMD) and mortality highlighted the elderly population with limited sample size. Our study aimed to ascertain the relationships in general population. Methods: This study ascertained the relationships between BMD levels in femur and lumbar spine with all-cause and cause-specific mortality in the National Health and Nutrition Examination Survey (NHANES) (n = 15,076, mean age 48.6 years). Cox proportional hazards models were adopted to calculate the hazard ratios (HR) and the corresponding 95% confidence intervals (CIs) for mortality. Results: During a 6.8-year median follow-up, 1216 men and women in the cohort died. There was a higher risk of all-cause mortality among participants with osteoporosis compared with normal in the regions of total femur (HR = 1.36, 95% CI = 1.07-1.73), femur neck (HR = 1.41, 95% CI = 1.11-1.78), intertrochanter (HR = 1.34, 95% CI = 1.05-1.72), as well as overall (HR = 1.36, 95% CI = 1.09-1.69). Non-linear dose-response analyses showed a statistically significant L-shaped association for all-cause mortality with BMD increment in the regions of total femur, femur neck, trochanter, and intertrochanter. The protective role of higher BMD level in femur for decreased risk of cancer mortality and heart diseases mortality was more evident in male participants and female participants, respectively. Conclusions: In summary, our results revealed that maintaining normal BMD is critical to lower the risk of mortality. The association between higher BMD level in femur and decreased risk of cancer as well as heart diseases mortality varies by gender.

The potential association of exposure to phthalates with muscle strength was reported in previous animal experiments. However, their association was rarely directly investigated in general populations. Thus, we aimed to ascertain the association of exposure to phthalates with grip strength using cross-sectional analysis which included 2436 individuals aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) during 2011–2014. The multivariable linear regression models were performed with the adjustment of related covariates. The results suggested that a one-unit increase in log-transformed phthalate metabolites (μg/g creatinine) was inversely associated with grip strength, including Mono-(2-ethyl)-hexyl phthalate (β: −2.727 kg, 95% CI: −3.452, −2.002), Mono-(2-ethyl-5-hydroxyhexyl) phthalate (β: −3.721 kg, 95% CI: −4.836, −2.607), Mono-(2-ethyl-5-oxohexl) phthalate (β: −4.669 kg, 95% CI: −5.761, −3.577), Mono-2-ethyl-5-carboxypentyl phthalate (β: −4.756 kg, 95% CI: −5.957, −3.554), Mono-carboxyoctyl phthalate (β: −1.324 kg, 95% CI: −2.412, −0.235), Mono-carboxynonyl phthalate (β: −2.036 kg, 95% CI: −3.185, −0.886), Mono-benzyl phthalate (β: −2.940 kg, 95% CI: −3.853, −2.026), Mono-n-butyl phthalate (β: −2.100 kg, 95% CI: −3.474, −0.726), Mono-isobutyl phthalate (β: −2.982 kg, 95% CI: −4.331, −1.633), and Mono-ethyl phthalate (β: −1.709 kg, 95% CI: −2.368, −1.050). In subgroup analyses, the associations remained largely unchanged when the samples were stratified by gender and age; However they became ambiguous among underweight subjects when the samples were stratified by BMI status. Overall, exposure to phthalates was inversely associated with grip strength among US adults, regardless of their genders and ages. The suggestive potential BMI status-specific effects of phthalates on grip strength were observed.

Phthalates have extensive existence in the living environment of human, probably tightly associated with multiple human diseases. The present study aimed to exploratorily investigate the association of urinary phthalate metabolites with osteoarthritis (OA) in American adults by exploiting the data extracted from National Health and Nutrition Examination Survey (NHANES) 2003-2014 with levels of eleven urinary phthalate metabolites as exposure. The multivariable logistic regression models were performed after controlling for urinary creatinine, age, gender, race/ethnicity, education level, marital status, smoking, body mass index, physical activity in recreational time, family poverty income ratio, diabetes, hypertension, as well as survey cycle. Compared with those in the lowest quantile, we observed higher prevalence of OA in the maximal quantile of MCOP (OR = 1.55, 95% CI = 1.06-2.27) in adjusted model. A one-unit increase in log-transformed phthalate metabolites was significantly associated with higher OA prevalence, including MCOP (OR = 1.13, 95% CI = 1.02-1.26) and MBzP (OR = 1.12, 95% CI = 1.00-1.26) in adjusted model. In subgroup analysis, the positive associations between phthalate metabolites and OA prevalence remained robust both in males and females. In brief, this study first presented positive evidence for the association of urinary level of phthalate metabolites with OA prevalence in American adults. Additional causal research is required to confirm the finding from our analysis and elucidate the potential underlying mechanisms of phthalates exposure on OA.

OBJECTIVES:The relationship between dietary inflammatory index (DII) and upper aerodigestive tract (UADT) cancer risk have been investigated in a growing number of epidemiological studies. However, their findings were inconsistent, and no systematic review or meta-analysis has been conducted up to now. This meta-analysis was carried out to examine potential dose-response relationship between DII score and UADT cancer risk.MATERIAL AND METHODS:A systematic search was conducted for relevant studies in PubMed and Web of Science up to March 28, 2019. Categorical meta-analysis as well as linear and non-linear dose-response meta-analysis were performed to evaluate association between DII and UADT cancer risk.RESULTS:Nine case-control studies with a total of 4138 cases and 15,326 healthy controls were eligible in the present meta-analysis. The pooled odds ratios (ORs) of UADT cancer risk were 2.07 [95% confidence interval (CI): 1.82, 2.35] for the highest DII score compared with the lowest and 1.53 (95% CI: 1.39, 1.69) for higher DII score compared with lower score, respectively. Furthermore, a one-unit increment in DII score was associated with an increased risk of 18% for UADT cancers (OR: 1.18; 95% CI: 1.15, 1.21). An upward trend towards a positive association between elevated DII score and UADT cancer risk was also observed in non-linear dose-response meta-analysis.CONCLUSIONS:The present meta-analysis provides evidence of highly pro-inflammatory diets that might increase risk of UADT cancers. Therefore, reducing pro-inflammatory components in diets should be considered to prevent and control UADT cancers.

Phenols and parabens are two major classes of endocrine-disrupting compounds (EDCs) that may be related to multiple human diseases. However, there has been no studies examining the association between phenols as well as parabens and osteoarthritis (OA). We assessed the link between urinary concentrations of triclosan (TCS), benzophenone-3 (BP-3), bisphenol A (BPA), and parabens with OA based on the data collected from National Health and Nutrition Examination Survey in multivariable logistic regression models. Among all the 7114 participants included, the weighted percentage of OA was 12.11% (n = 807). Compared with participants at tertile 1, those at tertile 2 of urinary BP-3, and tertile 3 of urinary BP-3 were more likely to show increased OA prevalence in a fully adjusted model, with odd ratio (OR) as 1.34 [95% confidence interval (CI): 1.01-1.78], 1.55 (95 CI%: 1.17-2.06), and 1.66 (95 CI%: 1.23-2.24), respectively. In subgroup analyses stratified by potential confounders, various subgroups remained to show statistically significant positive association between urinary BP-3 and OA prevalence. Otherwise, we observed no statistically significant associations between urinary TCS, BPA or parabens with OA. In conclusion, this serves as the first study in which we found that the urinary concentration of BP-3 was positively correlated to prevalence of OA among the US population.

目的 分析咖啡摄入与东亚人群恶性肿瘤死亡风险的关联.方法 检索中国知网、 万方数据知识服务平台、 维普中文科技期刊数据库和PubMed,收集建库至2018年12月10日国内外发表的有关亚洲人群咖啡摄入与恶性肿瘤死亡风险关联研究的文献;采用Stata 15.0软件对纳入的文献进行分类Meta分析和剂量-反应Meta分析.结果共检索到相关文献335篇,最终纳入分析5篇,其中4篇研究日本人群,1篇研究新加坡华人人群,总样本量为361802人,恶性肿瘤死亡17664例.咖啡摄入降低东亚人群的恶性肿瘤死亡风险(RR=0.93,95％CI:0.87～0.99);其中咖啡摄入与东亚男性恶性肿瘤死亡风险未见统计学关联(RR=0.94,95％CI:0.77～1.15),但可使东亚女性恶性肿瘤死亡风险下降12％(RR=0.88,95％CI:0.81～0.95).恶性肿瘤死亡风险总体随咖啡摄入量增加呈降低趋势,每天饮1.5杯咖啡,恶性肿瘤死亡风险最低(RR=0.92,95％CI:0.86～0.98).结论 咖啡摄入可以降低东亚人群恶性肿瘤死亡风险, 这种保护作用对女性更为明显; 每天饮1.5杯咖啡, 恶性肿瘤的死亡风险最低.

•This is the first dose-response meta-analysis to assess sleep time and cancer mortality.•Total sleep time of 4–5 hours was associated with all cancer mortality.•Total sleep time longer than 8 hours was associated with all cancer mortality.

Context: Laboratory studies have demonstrated that triclosan (TCS) can cause significant interstitial collagen accumulation and an increase in trabecular bone. However, little is known about the relationship between TCS exposure and human bone health. Methods: We used 2005 to 2010 National Health and Nutrition Examination Survey data to examine the association between urinary TCS concentration and bone mineral density (BMD) and osteoporosis in US adult women aged > 20 years. After inclusion and exclusion, 1848 women were analyzed. Results: After adjustment for other covariates, we observed significant associations between tertile 3 of TCS concentration and lower BMD in regions of the total femur (beta = -0.016; 95% CI = -0.032, -0.000), intertrochanteric region (beta = -0.022; 95% CI = -0.042, -0.002), and lumbar spine (beta = -0.014; 95% CI = -0.029, 0.001), respectively, relative to tertile 1. Compared with women at tertile 1, those at tertile 3 were more likely to have increased prevalence of osteoporosis in the intertrochanteric region (OR = 2.464; 95% CI = 1.190, 5.105). Conclusion: This epidemiological study investigated the association between urinary TCS concentration and BMD and osteoporosis in US adult women. We found urinary TCS concentration was negatively associated with BMD and was positively associated with the prevalence of osteoporosis. The evidence was stronger in postmenopausal women than in premenopausal women. Future prospective studies are needed to validate these findings.

The purpose of this study was to explore the association between urinary concentrations of polycyclic aromatic hydrocarbon (PAH) metabolites and the prevalence of rheumatoid arthritis (RA). Cross-sectional data were analyzed from the National Health and Nutrition Examination Survey (NHANES) 2003-2012 using levels of nine monohydroxylated urinary PAH metabolites as exposure. Multivariable logistic regression was used to examine the association between urinary biomarkers of PAHs and RA. All of the models were adjusted for age, sex, race, education level, marital status, smoking, BMI, physical activity, energy, diabetes, and survey cycle. Ultimately, 6,072 adults (3,108 men and 2,964 women) 20 years of age or older were analyzed. In the quartile analyses, compared with the lowest quartile, increased RA prevalence was observed in the participants with the highest quartile of 2-hydroxynapthalene (OR = 1.89, 95% CI = 1.28-2.78), 3-hydroxyfluorene (OR = 1.55, 95% CI = 1.07-2.25), 2-hydroxyfluorene (OR = 1.51, 95% CI = 1.02-2.24), 3-hydroxyphenanthrene (OR = 1.50, 95% CI = 1.09-2.07), and 9-hydroxyfluorene (OR = 1.60, 95% CI = 1.10-2.33) in a fully adjusted model, respectively. In the subgroup analysis of current smokers, compared with the participants with lower urinary PAH scores, those with higher scores had a dramatically increased prevalence of RA (OR = 15.46, 95% CI = 3.11-76.75) in the adjusted model. There was a significant interaction between all of the urinary PAH metabolite levels and smoking status in the relationship with RA (P < 0.05). High levels of urinary PAH metabolites are positively associated with RA prevalence in the US general population. PAH exposure and smoking may potentially interact to increase the prevalence of RA. Further prospective studies are needed to clarify the possible effect of PAHs on RA.

Objective To investigate the influences of hypertension awareness on people's physical activity level,and provide evidence for prevention and control of hypertension.Methods Data of 4 cross-sectional studies from "China Health and Nutrition Survey" were downloaded and re-analyzed.The trend of hypertension prevalence and awareness were analyzed and the associated hypertension awareness and physical activity level was evaluated.Results Hypertension prevalence rose from 23.99％ to 28.28％ and hypertension awareness rose from 39.48％ to 57.01％ during 2004-2011,the trends showed statistical significance (x2=177.89,P＜0.01).People who had and were aware of hypertension showed a higher physical activity participation rate as well as enough participation duration rate than those who did not have hypertension (x2=62.62 and 69.73,P both＜0.01) or were not aware of their hypertension (x2=16.81 and 34.71,P both ＜0.01),while people who had and were aware of hypertension showed a long sedentary behavior rate much more than those who did not have hypertension (x2=7.01,P＜0.05) or were not aware of their hypertension (x2=34.15,P＜0.01).Logistic regression showed that,after revising relative risk factors of age and gender,physical activity participation rate (OR=1.29,95％CI:1.12-1.49) and enough participation duration rate (OR =1.31,95％CI:1.13-1.53) were significantly and positively associated with hypertension awareness.Conclusions Hypertension awareness may have positive influence on physical activity participation level in hypertension patients,while it has no significant influence in reducing people's leisure time sedentary behavior.So it is recommended to reinforce the health education on reducing sedentary behavior in hypertension patients.

Colorectal cancer associated transcript 1 (CCAT1) is a novel long noncoding RNA, whose overexpression is evident in both early phase of tumorigenesis and later disease stages in colorectal cancer (CRC). No study has explored the relationship between CCAT1 polymorphisms and CRC risk. In the present study, a case-control study was conducted to investigate the association between CCAT1 polymorphisms and CRC risk in Chinese population. We identified that CCAT1 rs67085638 polymorphism was associated with an increased risk of CRC (OR = 1.72, 95%CI = 1.14-2.58, P = 0.009 in heterozygote codominant model; OR = 1.67, 95%CI = 1.13-2.47, P = 0.010 in dominant model). Moreover, CCAT1 rs7013433 polymorphism was associated with late clinical stage (OR = 1.82, 95%CI = 1.16-2.86, P = 0.009 in heterozygote codominant model; OR = 1.72, 95%CI = 1.13-2.63, P = 0.012 in dominant model). Our finding proposed a link between CCAT1 polymorphisms with CRC risk as well as different clinical stages.

目的 了解中国儿童青少年含糖饮料消费趋势及与肥胖的关系,为预防和控制儿童青少年肥胖提供依据.方法 利用"中国居民健康与营养调查"项目公开数据库中2004年、2006年、2009年和2011年的横断面调查数据,分析我国儿童青少年含糖饮料消费情况及趋势,并探索儿童青少年消费量与超重/肥胖的关系.结果 儿童青少年含糖饮料消费比例由2004年的73.58％上升至2011年的90.49％,平均消费量由1.2 L/周上升至1.5 L/周,超重/肥胖率由10.19％上升至20.01％,差异均有统计学意义(P<0.05).Logistic回归分析结果显示,在校正性别、 年龄、 城乡分布和零食偏好等因素后,含糖饮料消费量高(OR=1.231,95％CI:1.118～1.354)仍是儿童青少年超重/肥胖的危险因素.结论 我国儿童青少年的含糖饮料消费比例和消费总量均呈上升趋势,含糖饮料消费量与儿童青少年超重/肥胖的风险存在统计学关联,建议儿童青少年适当控制含糖饮料的摄入总量.

目的:采用网状Meta分析评价4种不同教学方法对医学统计学教学效果的影响.方法:计算机检索中国知网、万方数据库、维普数据库中有关不同教学方法对医学统计学教学效果影响的研究,末次检索时间为2018年4月.按照纳入标准进行文章的选择,运用GeMTC14.3和Stata 13.0软件进行Meta分析.结果:共纳入文章19篇,网状Meta分析结果显示:案例教学法、以问题为基础教学法、翻转课堂教学法对比传统的讲授教学法,在影响医学统计学教学效果方面差异具有统计学意义(P<0.05);根据累积排序概率曲线下面积排序结果,案例教学法是提高医学统计学教学效果的较优方法.结论:基于网状Meta分析结果和累积排序概率图下面积排序结果,案例教学法对提高医学统计学教学效果优于其他.

目的 探讨长链非编码RNA尿路上皮癌胚抗原1(UCA1)表达水平及其启动子区域的单核苷酸多态性与结直肠癌发生发展的关系,为其作为结直肠癌风险的分子标志物提供依据.方法 分别纳入507例原发性结直肠癌患者和503例健康志愿者为病例组和对照组,采集血液检测UCA1 rs7255437位点单核苷酸多态性,分析UCA1 rs7255437多态性与结直肠癌发病的关联.采用生物信息学方法验证UCA1表达与rs7255437多态性及结直肠癌发病的关联.结果 与rs7255437 CC基因携带者相比,CT和TT基因型携带者发生结直肠癌的风险均升高,但差异均无统计学意义(P>0.05);与rs7255437 CC基因携带者相比,TT基因携带者发生晚期结直肠癌的风险降低67％(P<0.05).生物信息学分析结果显示,在正常横结肠组织和小肠组织中,CT和TT基因携带者UCA1表达水平均高于CC基因携带者;结直肠癌晚期患者肠癌组织中UCA1表达水平高于结直肠癌早期患者(P<0.05).结论 UCA1表达水平及其启动子区域rs7255437单核苷酸多态性作为结直肠癌风险的分子标志物具有一定潜力,但有待于基于自然人群的大样本前瞻性队列研究以及功能学研究进一步验证.