TP73-AS1 is a novel antisense long noncoding RNA and plays an important role in cell proliferation and cancer development. However, the link between TP73-AS1 and colorectal cancer (CRC) has not yet been reported. To explore the association of genetic variants in TP73-AS1 and its expression with CRC susceptibility and prognosis. A case–control study (including 507 CRC cases and 503 controls) and bioinformatics analysis were conducted. rs9800 polymorphism was significantly related to higher risk in CRC [adjusted odds ratio (AOR) = 1.33, 95% confidence interval (CI) = 1.02–1.75, P = 0.034 in heterozygote codominant model]. There was no difference between TP73-AS1 polymorphisms and different tumor node metastasis (TNM) stages in the adjusted model. Moreover, TP73-AS1 expression level was positively related to different TNM stages. After adjusted for age, gender and TNM, higher TP73-AS1 expression levels were related to shorter recurrence-free survival time [hazard ratio (HR) = 1.66, 95% CI = 1.02–2.71, P = 0.043]. TP73-AS1 polymorphisms and expression may be associated with susceptibility and prognosis of CRC.

AbstractPurposePsychological well-beings of left-behind children (LBC) in rural areas of China remain under-studied. In this cross-sectional study, we aimed to explore the subjective well-being (SWB) in LBC and its associated factors in a rural area in eastern China.MethodsStratified random cluster sampling was used to select middle school and high school students in Qingyuan County of Zhejiang Province. Relevant information including sociodemographic characteristics was collected from each participant using an organized questionnaire. SWB was measured using the modified scale developed for Chinese adolescents. Univariable and multivariable regression analyses were performed using R version 3.3.0.ResultsA total of 1086 children were recruited and examined in the current analysis, with 365 (33.61%) being left-behind. Compared with non-left-behind children (NLBC), LBC had significantly lower scores in family satisfaction (P = 0.003) and environment satisfaction (P = 0.020). Multivariable regression analysis uncovered that frequent parent–child communication was associated with high positive affect (P = 0.003) and life satisfaction (P < 0.001), and the type of caregivers was associated with negative affect among LBC (P = 0.037).ConclusionsOur results suggest SWB was lower in LBC, and targeted interventions including strengthening parental-child communication should be developed and implemented to improve LBC’s SWB in rural areas of China.

目的 通过分析公共数据库资源初步探索Claudin家族基因表达水平与其在卵巢癌发生、发展中的作用.方法 首先利用Gene Expression Omnibus数据库获取Claudin家族基因在正常卵巢组织、早期卵巢癌组织、晚期卵巢癌组织中的表达水平,然后通过R语言分析得到在上述3种组织中两两比较表达水平均有统计学差异的基因,进一步在Kaplan Meier-plotter数据库上针对差异表达基因进行预后(OS)及复发(PFS)分析.结果 在正常卵巢组织、早期卵巢癌及晚期卵巢癌之间两两比较表达水平均有统计学差异(均P<0.05)的基因为7个,分别为Claudin1、4、6、7、10、14、18基因;OS及PFS分析发现,Claudin7、14的基因表达水平对卵巢癌的PFS具有显著影响(P=0.0456、0.0247);同时,Claudin4、6、10的基因表达水平对卵巢癌的OS具有显著影响(P=0.0265、0.0296、0.0278).结论 本研究揭示了Claudin家族基因与卵巢癌的进展及预后显著相关,从而为进一步研究其具体分子机制奠定工作基础,为探索卵巢癌治疗新靶点提供科学证据.

Background: RP11-108K3.2 was recently identified as a novel long non-coding RNA (lncRNA) transcript, and several single nucleotide polymorphisms (SNPs) have been identified in its coding region. This study aimed to explore the associations of tagSNPs in RP11-108K3.2 with the risk of colorectal cancer and their effects on its expression. Methods: A total of 821 colorectal cancer cases and 857 healthy controls were enrolled into this two-stage case-control study. Demographic characteristics and lifestyle information were collected by a validated questionnaire. Six tagSNPs were genotyped by using Sequenom MassARRAY platform. A total of 71 additional colorectal cancer cases were recruited, of which the genotypes of potential polymorphisms and the RP11-108K3.2 expression levels were determined. Results: In the discovery set, only the rs2470151 C/T polymorphism was found to have a promising association with the risk of colorectal cancer, and this polymorphism was further replicated in the validation set with a significantly decreased risk of colorectal cancer (adjusted odds ratio 0.73; 95% confidence interval 0.55, 0.97). Combined discovery set and validation set together, this negative association was found both in the heterozygote codominant model and the dominant model. Furthermore, colorectal cancer patients carrying rs2470151 CT/TT genotypes had a marginally lower RNA expression of RP11-108K3.2 than those carrying the CC genotype. Stratified analyses showed the association between rs2470151 and the risk of colorectal cancer were influenced by family history of cancer, smoking, alcohol consumption, and tea drinking. Conclusions: These findings suggest that RP11-108K3.2 rs2470151 had a significant association with the risk of colorectal cancer; this may help to predict the susceptibility of colorectal cancer in Chinese populations.

Objective To investigate the influences of hypertension awareness on people's physical activity level,and provide evidence for prevention and control of hypertension.Methods Data of 4 cross-sectional studies from "China Health and Nutrition Survey" were downloaded and re-analyzed.The trend of hypertension prevalence and awareness were analyzed and the associated hypertension awareness and physical activity level was evaluated.Results Hypertension prevalence rose from 23.99％ to 28.28％ and hypertension awareness rose from 39.48％ to 57.01％ during 2004-2011,the trends showed statistical significance (x2=177.89,P＜0.01).People who had and were aware of hypertension showed a higher physical activity participation rate as well as enough participation duration rate than those who did not have hypertension (x2=62.62 and 69.73,P both＜0.01) or were not aware of their hypertension (x2=16.81 and 34.71,P both ＜0.01),while people who had and were aware of hypertension showed a long sedentary behavior rate much more than those who did not have hypertension (x2=7.01,P＜0.05) or were not aware of their hypertension (x2=34.15,P＜0.01).Logistic regression showed that,after revising relative risk factors of age and gender,physical activity participation rate (OR=1.29,95％CI:1.12-1.49) and enough participation duration rate (OR =1.31,95％CI:1.13-1.53) were significantly and positively associated with hypertension awareness.Conclusions Hypertension awareness may have positive influence on physical activity participation level in hypertension patients,while it has no significant influence in reducing people's leisure time sedentary behavior.So it is recommended to reinforce the health education on reducing sedentary behavior in hypertension patients.

Colorectal cancer associated transcript 1 (CCAT1) is a novel long noncoding RNA, whose overexpression is evident in both early phase of tumorigenesis and later disease stages in colorectal cancer (CRC). No study has explored the relationship between CCAT1 polymorphisms and CRC risk. In the present study, a case-control study was conducted to investigate the association between CCAT1 polymorphisms and CRC risk in Chinese population. We identified that CCAT1 rs67085638 polymorphism was associated with an increased risk of CRC (OR = 1.72, 95%CI = 1.14-2.58, P = 0.009 in heterozygote codominant model; OR = 1.67, 95%CI = 1.13-2.47, P = 0.010 in dominant model). Moreover, CCAT1 rs7013433 polymorphism was associated with late clinical stage (OR = 1.82, 95%CI = 1.16-2.86, P = 0.009 in heterozygote codominant model; OR = 1.72, 95%CI = 1.13-2.63, P = 0.012 in dominant model). Our finding proposed a link between CCAT1 polymorphisms with CRC risk as well as different clinical stages.

目的 了解中国儿童青少年含糖饮料消费趋势及与肥胖的关系,为预防和控制儿童青少年肥胖提供依据.方法 利用"中国居民健康与营养调查"项目公开数据库中2004年、2006年、2009年和2011年的横断面调查数据,分析我国儿童青少年含糖饮料消费情况及趋势,并探索儿童青少年消费量与超重/肥胖的关系.结果 儿童青少年含糖饮料消费比例由2004年的73.58％上升至2011年的90.49％,平均消费量由1.2 L/周上升至1.5 L/周,超重/肥胖率由10.19％上升至20.01％,差异均有统计学意义(P<0.05).Logistic回归分析结果显示,在校正性别、 年龄、 城乡分布和零食偏好等因素后,含糖饮料消费量高(OR=1.231,95％CI:1.118～1.354)仍是儿童青少年超重/肥胖的危险因素.结论 我国儿童青少年的含糖饮料消费比例和消费总量均呈上升趋势,含糖饮料消费量与儿童青少年超重/肥胖的风险存在统计学关联,建议儿童青少年适当控制含糖饮料的摄入总量.

目的:采用网状Meta分析评价4种不同教学方法对医学统计学教学效果的影响.方法:计算机检索中国知网、万方数据库、维普数据库中有关不同教学方法对医学统计学教学效果影响的研究,末次检索时间为2018年4月.按照纳入标准进行文章的选择,运用GeMTC14.3和Stata 13.0软件进行Meta分析.结果:共纳入文章19篇,网状Meta分析结果显示:案例教学法、以问题为基础教学法、翻转课堂教学法对比传统的讲授教学法,在影响医学统计学教学效果方面差异具有统计学意义(P<0.05);根据累积排序概率曲线下面积排序结果,案例教学法是提高医学统计学教学效果的较优方法.结论:基于网状Meta分析结果和累积排序概率图下面积排序结果,案例教学法对提高医学统计学教学效果优于其他.

Polycyclic aromatic hydrocarbons (PAHs) are environmental endocrine disruptors, which may modify the bone mineralization. However, epidemiological evidences on this issue were scant. We aimed to investigate the associations of PAHs with bone mass density (BMD) and osteoporosis based on a nationally-representative sample from general U.S. POPULATION:Data utilized were extracted from the 2005-2010 National Health and Nutrition Examination Survey (NHANES). Nine urinary PAHs (U-PAHs) metabolites were measured as exposure biomarkers. Associations of specific U-PAHs with BMD and osteoporosis were estimated by multivariable adjusted linear regression models and logistic regression models, respectively. Compared with women at the first tertiles, those at the third tertiles of 1-Hydroxynapthalene, 2-Hydroxyfluorene, 3-Hydroxyphenanthrene, 2-Hydroxyphenanthrene and 9-Hydroxyfluorene had significantly decreased BMD levels [coefficient (β) = -0.023 to -0.014, p < 0.05] or increased likelihoods of osteoporosis [odds ratios (ORs) = 1.86 to 3.36, p < 0.05] at different bone sites. Whereas, elevated BMD levels (β = 0.021, p < 0.05) at trochanter and decreased likelihoods of osteoporosis (OR = 0.33, p < 0.05) at intertrochanter were observed among women at the second tertiles of 1-Hydroxypyrene and 2-Hydroxynapthalene, respectively. Similar results were found for all the population, i.e., combination of men and women. Most of the significant associations disappeared among adult men only. Furthermore, Associations between U-PAHs and BMD were stronger for postmenopausal women when compared with premenopausal group. In conclusion, associations of U-PAHs with BMD and osteoporosis varied by specific U-PAHs and bone sites, as well as menopausal status and genders in U.S. adults.

目的 探讨长链非编码RNA尿路上皮癌胚抗原1(UCA1)表达水平及其启动子区域的单核苷酸多态性与结直肠癌发生发展的关系,为其作为结直肠癌风险的分子标志物提供依据.方法 分别纳入507例原发性结直肠癌患者和503例健康志愿者为病例组和对照组,采集血液检测UCA1 rs7255437位点单核苷酸多态性,分析UCA1 rs7255437多态性与结直肠癌发病的关联.采用生物信息学方法验证UCA1表达与rs7255437多态性及结直肠癌发病的关联.结果 与rs7255437 CC基因携带者相比,CT和TT基因型携带者发生结直肠癌的风险均升高,但差异均无统计学意义(P>0.05);与rs7255437 CC基因携带者相比,TT基因携带者发生晚期结直肠癌的风险降低67％(P<0.05).生物信息学分析结果显示,在正常横结肠组织和小肠组织中,CT和TT基因携带者UCA1表达水平均高于CC基因携带者;结直肠癌晚期患者肠癌组织中UCA1表达水平高于结直肠癌早期患者(P<0.05).结论 UCA1表达水平及其启动子区域rs7255437单核苷酸多态性作为结直肠癌风险的分子标志物具有一定潜力,但有待于基于自然人群的大样本前瞻性队列研究以及功能学研究进一步验证.

目的:了解全面二孩政策实施后浙江省居民二孩生育意愿及影响因素.方法:选择杭州市农村社区和城镇居民社区各两个,对育龄居民进行二孩生育意愿及影响因素的问卷调查.结果:城市居民生育意愿率为66.44％,农村居民生育意愿率为64.81％,两者之间没有差别;20～39岁年龄段人群的生育意愿高于40岁以上的人群;农村居民,个体工商户的生育意愿较高;城市居民,本人和配偶是单独或双独的生育意愿高于双非的生育意愿;不要二孩的主要原因是家庭经济负担增加、无人照顾和年龄高生育风险大,有生育二孩意愿的主要原因是让孩子有伴、自己将来有更好保障.结论:提高经济收入,完善社会保障,有助于二孩政策的实施.

Single-nucleotide polymorphisms (SNPs) in the promoter region of long intergenic non-coding RNAs (lincRNAs) could play a regulatory role in its expression level and then get involved in colorectal cancer (CRC). Thus, we conducted a two-stage case–control study to investigate the associations of Tag SNPs within the promoter region of selected lincRNAs from microarray data with risk of CRC. A total of 320 cases and 319 controls were recruited in the test set to explore the associations between 16 SNPs with no deviations from Hardy–Weinberg equilibrium (HWE) and risk of CRC. Furthermore, 501 cases and 538 controls were included as the validation set to confirm the significant associations. RP11-3N2.1 rs13230517 polymorphism was found to be negatively associated with CRC in both test set (AA vs. GG, OR = 0.68, 95% CI = 0.48–0.96) and validation set (AA vs. GG, OR = 0.76, 95% CI = 0.59–0.98). Pooled analysis showed that individuals with GA/AA genotypes had a significantly decreased risk of CRC when compared with those carrying GG genotype (OR = 0.74, 95% CI = 0.60–0.90) in the combined set. The crossover analysis revealed that rs13230517 GA/AA carriers had a decreased risk of CRC than GG carriers among non-drinkers in both test and combined set. However, no gene-environment multiplicative interactions were found on risk of CRC. Our findings suggest that rs13230517 polymorphism might participate in the pathogenesis of CRC and have the potential to be a biomarker for predicting the risk of CRC.

In 2006, China targeted measles for elimination by 2012, but the goal was not achieved. In line with this goal, the timeliness of measles laboratory reporting should be evaluated to improve efficiency in implementing control measures. Laboratory-confirmed suspected measles cases reported to the measles surveillance system in Zhejiang Province, China, from 2009 to 2015 were collected. Three reporting periods were defined: transport duration (period from serum collected to serum received in lab), analysis duration (period from serum received to the result being reported), and total reporting duration. The median was calculated for each period. Associations between total reporting delay and other factors were accessed using logistic regression model. A total of 18,518 laboratory-confirmed suspected measles cases were collected. For transport duration, the median was within 1 day, and no variation was observed among different years. For analysis duration, the median decreased from 3 days in 2009 to 1 day in 2015. For total reporting duration, the median decreased from 5 days in 2009 to 2 days in 2015. The median of total delay was 13 days during the 7 years. The proportion of cases notified within the time limit was found to increase, indicating a tendency toward more efficient laboratory reporting. Moreover, timeliness was influenced by various external factors: reporting from CDC, reporting from counties with higher economic status, and reporting in spring were the variables associated with shorter delays. Timeliness of measles laboratory reporting has increased annually in China. Health administration departments need to pay more attention to measles laboratory surveillance in counties with lower economic status.

Long non-coding RNAs (lncRNAs) are widely transcribed in the genome, but their expression profile and roles in colorectal cancer are not well understood. The aim of this study was to investigate the long non-coding RNA expression profile in colorectal cancer and look for potential diagnostic biomarkers of colorectal cancer. Long non-coding RNA microarray was applied to investigate the global long non-coding RNA expression profile in colorectal cancer. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed using standard enrichment computational methods. The expression levels of selected long non-coding RNAs were validated by quantitative reverse transcription polymerase chain reaction. The relationship between long non-coding RNA expression levels and clinicopathological characteristics of colorectal cancer patients was assessed. Coexpression analyses were carried out to find the coexpressed genes of differentially expressed long non-coding RNAs, followed by gene ontology analysis to predict the possible role of the selected long non-coding RNAs in colorectal carcinogenesis. In this study, a total of 1596 long non-coding RNA transcripts and 1866 messenger RNA transcripts were dysregulated in tumor tissues compared with paired normal tissues. The top upregulated long non-coding RNAs in tumor tissues were CCAT1, UCA1, RP5-881L22.5, NOS2P3, and BC005081 and the top downregulated long non-coding RNAs were AK055386, AC078941.1, RP4-800J21.3, RP11-628E19.3, and RP11-384P7.7. Long non-coding RNA UCA1 was significantly upregulated in colon cancer, and AK055386 was significantly downregulated in tumor with dimension <5 cm. Functional prediction analyses showed that both the long non-coding RNAs coexpress with cell cycle related messenger RNAs. The current long non-coding RNA study provided novel insights into expression profile in colorectal cancer and predicted the potential roles of long non-coding RNAs in colorectal carcinogenesis. Among the dysregulated long non-coding RNAs, UCA1 was found to be associated with anatomic site, and AK055386 was found associated with tumor size. Further functional investigations into the molecular mechanisms are warranted to clarify the role of long non-coding RNA in colorectal carcinogenesis.

The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-known long non-coding RNA, is involved in pathogenesis and progress of multiple tumors. However, no study has been performed to investigate the relationship between the genetic variants in promoter region of MALAT1 and colorectal cancer risk. In this study, we conducted a two-stage case-control study to evaluate whether MALAT1 genetic variants were associated with colorectal cancer risk. We identified that a single nucleotide polymorphism (SNP) rs1194338 was significantly associated with the decreased colorectal cancer risk with an odds ratio (OR) of 0.70 [95% confidence interval (CI) = 0.49-0.99] in the combined stage. The subsequently stratified analyses showed that the protective effect of rs1194338 was more pronounced in several subgroups. Furthermore, gene expression profiling analysis revealed overexpression of MALAT1 mRNA in colorectal cancer tissue compared with normal controls. Confirmation studies with large sample size and further mechanistic investigations into the function of MALAT1 and its genetic variants are warranted to advance our understanding of their roles in colorectal carcinogenesis, and to aid in the development of novel and targeted therapeutic strategies.

Objective To screen the key genes of colon cancer and to explore the pathogenesis of colon cancer. Methods The expression data were searched from Gene Expression Omnibus (GEO) and the differentially expressed genes were selected by GEO2R. The differentially expressed genes were analyzed by gene ontology (GO) , KEGG pathway and protein-protein interaction networks. Results A total of 324 differentially expressed genes including 61 upregulated genes and 263 downregulated genes were found in more than three GEO series. An analysis of differentially expressed gene pathways revealed that bile secretion, drug metabolism, cytochrome P450, and chemical carcinogenesis were involved in the pathogenesis of colon cancer. Thus 9 key genes were identified, including BMP2, CXCL1, CXCL12, CXCL2, GCG, IL8, MMP1, PHLPP2 and PYY. Conclusion The key genes could be screened by bioinformatics effectively, which might provide the basis for further experimental study.

BACKGROUND:This study aimed to investigate the associations of selected polymorphisms in RP11-650L12.2 with the risk of colorectal cancer (CRC) in a Chinese population.METHODS:A total of 821 CRC cases (test set: 320, validation set: 501) and 857 healthy controls (test set: 319, validation set: 538) were enrolled in this study. Demographic characteristics and lifestyle information were collected by a validated questionnaire. A sample of 5ml venous blood was collected from each subject for DNA isolation, and the selected polymorphisms (rs144182521, rs514743, rs76071148, rs149941240) were genotyped by MassArray technique.RESULTS:The rs149941240 polymorphism was significantly associated with the risk of CRC, with ORs of 1.50 (95% CI: 1.15-1.96) by co-dominant model and 1.45 (95% CI: 1.21-1.87) by dominant model in the test set, respectively. Correspondingly, the ORs were 1.48 (95% CI: 1.19-1.82) and 1.41 (95% CI: 1.15-1.73) in the validation set, respectively. The crossover analysis showed that non-smokers with the variant genotypes in rs149941240 had a significantly increased risk of CRC than those with wild genotype by dominant model in the validation set (OR 1.42, 95% CI 1.04-1.96). However, no gene-environment multiplicative interactions of rs149941240 with tobacco smoking were found on risk of CRC.CONCLUSIONS:Our findings suggest that rs149941240 polymorphism was associated with the risk of CRC, and might contribute to the susceptibility to CRC. The effects of this polymorphism should be validated in a larger sample and require further mechanistic investigations to determine the nature of its influence on CRC.

There is a widespread occurrence of antisense transcripts' regulation on cancer-related genes in cancer biology. RP11-392P7.6 is antisense to the coding region of cancer-related gene GPRC5D , which has been found recently. The aim of this study was to investigate the associations of tagSNPs in the promoter region of RP11-392P7.6 with the risk of colorectal cancer. We conducted a two-stage case–control study, with a discovery set (320 cases and 319 controls) and a validation set (501 cases and 538 controls). Four tagSNPs (rs1531970, rs1642199, rs4763903, and rs10845671) were selected based on 1000 Genomes Project data and genotyped by using the Sequenom MassARRAY genotyping platform. In the discovery set, three tagSNPs (rs1642199, rs4763903, and rs10845671) were revealed promising associations with the risk of colorectal cancer, among which the rs10845671 variants were further replicated in the validation set (OR = 1.47, 95% CI = 1.10–1.20 in heterozygote codominant model; OR = 1.38, 95% CI = 1.04–1.83 in dominant model). When combined the two sets, the above positive associations remained unchanged. Rs10845671 was found to be associated with an increased risk of colorectal cancer (OR = 1.43, 95% CI = 1.14–1.81 in heterozygote codominant model; OR = 1.35, 95% CI = 1.08–1.69 in dominant model). These findings indicate that rs10845671 may contribute to the susceptibility to colorectal cancer and be a candidate biomarker for colorectal cancer risk prediction. Environ. Mol. Mutagen. 58:434–442, 2017. © 2017 Wiley Periodicals, Inc.

There is a widespread occurrence of antisense transcripts' regulation on cancer‐related genes in cancer biology. RP11‐392P7.6 is antisense to the coding region of cancer‐related gene GPRC5D, which has been found recently. The aim of this study was to investigate the associations of tagSNPs in the promoter region of RP11‐392P7.6 with the risk of colorectal cancer. We conducted a two‐stage case–control study, with a discovery set (320 cases and 319 controls) and a validation set (501 cases and 538 controls). Four tagSNPs (rs1531970, rs1642199, rs4763903, and rs10845671) were selected based on 1000 Genomes Project data and genotyped by using the Sequenom MassARRAY genotyping platform. In the discovery set, three tagSNPs (rs1642199, rs4763903, and rs10845671) were revealed promising associations with the risk of colorectal cancer, among which the rs10845671 variants were further replicated in the validation set (OR = 1.47, 95% CI = 1.10–1.20 in heterozygote codominant model; OR = 1.38, 95% CI = 1.04–1.83 in dominant model). When combined the two sets, the above positive associations remained unchanged. Rs10845671 was found to be associated with an increased risk of colorectal cancer (OR = 1.43, 95% CI = 1.14–1.81 in heterozygote codominant model; OR = 1.35, 95% CI = 1.08–1.69 in dominant model). These findings indicate that rs10845671 may contribute to the susceptibility to colorectal cancer and be a candidate biomarker for colorectal cancer risk prediction. Environ. Mol. Mutagen. 58:434–442, 2017. © 2017 Wiley Periodicals, Inc.

The relationship between physical activity (PA) before cancer diagnosis and all cancer mortality among the general population is not well defined because of inconsistent results from published studies. Thus, the lack of a meta‐analysis that addresses that issue prompted the current report. We conducted a literature search of PubMed and Web of Science to identify all relevant epidemiological studies published before February 28, 2015. We performed categorical and dose–response meta‐analyses to evaluate and quantify the association between pre‐diagnosis PA and all cancer mortality. A total of 32 prospective cohort studies involving 59,362 cancer deaths were included in this meta‐analysis. The pooled relative risks (RRs) of all cancer mortality were 0.80 [95% confidence interval (CI) = 0.76–0.85)] for highest versus lowest PA group and 0.85 (95% CI = 0.82–0.88) for PA versus non/occasional PA group. Dose–response analysis showed that the increment in pre‐diagnosis PA level was associated with a decreased risk of cancer death continuously. Moreover, an increment of 10 MET‐h/week was related to a 7% lower risk for all cancer mortality (RR = 0.93, 95% CI = 0.91–0.95). In conclusion, the present meta‐analysis provides evidence of an inverse association between pre‐diagnosis PA and all cancer mortality among the general population. High‐quality epidemiological studies that employ standardized PA assessments and unified definitions of PA levels should be developed in future.