For the last decade, owing to methods of computerized neuroradiology, it has been established that the process of the human organism natural aging is accompanied by a gradual atrophic reduction of the brain tissue volume and a decrease of the cerebral blood flow level, while the intracranial cerebrospinal fluid volume increases. The goal of the present study was to elucidate functional significance of the above changes in terms of interaction of intracranial hemo- and liquorocirculation systems at various stages of ontogenesis of practically healthy people. The total of 122 people aged from 6 to 100 years were examined at rest and during performance of goal-oriented functional physiological tests with simultaneous continuous recording of parameters of cerebral blood flow and liquorodynamics by methods of transcranial dopplerography and rheoencephalography. The obtained data are processed by means of the pattern and phasic two-dimensional analysis with use of special computer programs. In the same age groups, the brain neurophysiological activity was evaluated by applying special psychological tests. It has been shown that with age, on the background of a decrease of hemodynamic parameters of cerebral blood supply, there is observed an enhancement of the liquorodynamic factor of cerebral blood circulation due to an increase of the liquor volume and facilitation of its translocation in the single craniospinal cavity. The enhancement of the liquor-dependent mechanism of compensation of intracranial pulse oscillations of the blood volume is particularly expressed both in children and in elderly people due to a relatively high liquor volume. Owing to the improvement of intracranial liquorodynamic processes, the change of the cerebral blood circulation is compensated, which is confirmed by results of performed psychophysiological studies.

Oscilaciones ritmicas lentas (ORL) fueron estudiadas en el craneo humano usando dos metodos no invasivos: la Bio-impedancia (razon de volumenes entre la media de liquidos en la cavidad craneal) y el Eco-doppler intracraneal (variacion del flujo de sangre en la arteria cerebral media). La combinacion de estos dos metodos hizo posible estimar la hemodinamica intracraneal. La grabacion simultanea de estos dos parametros y su analisis espectral fue realizada en sujetos sanos, asi como en pacientes con Sindrome de Hipertension Intracraneal y alteraciones del Flujo Cerebroespinal (FCS). Los parametros fueron registrados en reposo e inmediatamente despues de una correccion manual (osteopatica). La grabacion y el analisis fueron realizados usando un computador Macintosh-IIsi, Cata 3.52, Grafico de grillo 3.32 y un programa Canvas 3.5. Se encontro que las oscilaciones lentas de la bio-impedancia (BIM) en el rango de frecuencia de 0.08-0.2 Hz eran de origen intracraneal, y que estaban relacionadas con los mecanismos de regulacion del suministro de sangre, con el consumo de oxigeno por el tejido cerebral y con la dinamica circulatoria del FCS.

Slow rhythmic oscillations in the human cranial cavity were studied using two noninvasive methods: the bioimpedance method (volume ratios between liquid media in the cranial cavity) and transcranial ultrasound Doppler echography (variation in the blood flow in the middle cerebral artery). The combination of these methods made it possible to estimate the intracranial hemodynamics. Simultaneous recording of these parameters and their spectral analysis were carried out in healthy subjects and patients with intracranial hypertension syndrome and disturbed cerebrospinal fluid (CSF) flow. The parameters were recorded at rest and immediately after manual (osteopathic) correction. The recording and analysis were performed using a Macintosh-IIsi PC and the Chart-3.52, Cricket Graph-3.32, and Canvas-3.5 software. It was found that slow oscillations of the bioimpedance (BIM) in the frequency range 0.08–0.2 Hz were of intracranial origin and were related to the mechanisms of regulation of the blood supply to and oxygen consumption by cerebral tissue, as well as with the dynamics of the CSF circulation.