Впервые исследовано взаимодействие трис(2-гидроксиэтил)амина с карбоксилатами Fe(III) и Mn(II). Образование комплексов подтверждено данными ИК спектроскопии и элементного анализа. Установлена кристаллическая структурациннаматамарганца(II) и исследована его термическая устойчивость.

Reference to the funding source is missing in the article:This study was performed in the framework of the project (no. 10.735.2014/K) and base parts (no. 10.7608.2017/8.9) of state assignment of the Ministry of Education and Science of the Russian Federation in the sphere of research activity.

Water-soluble forms of a series of 1-alkyl(aryl)imidazole-4,5-dicarboxylic acids were prepared. Anticonvulsant activity of 1-propylimidazole-4,5-dicarboxylic acid and its triethanolammonium salt was studied using the NMDA-induced convulsion model. The triethanolammonium salt of 1-propylimidazole-4,5-dicarboxylic acid was shown to possess anticonvulsant activity whereas the acid itself was a convulsant. The change of pharmacological profile was related to the formation of ion pairs or associates even in polar physiological media. The ability to associate was confirmed using conductivity measurements. An x-ray crystal structure analysis was performed for the triethanolammonium salt of 1-propylimidazole-4,5-dicarboxylic acid.

Aminomethylation of guanidine hydrochloride with aqueous formaldehyde and simplest amino acids depending on the reagents ratio results in bicyclic hydrochlorides (1: 4: 2) or tricyclic iminium chlorides (1: 6: 3) that in their turn may be converted into internal salts: zwitter-ions or betaines respectively.

A configuration of the triethanolammonium cation is determined by the X-ray diffraction method, and cation-anion interactions in its salts with oxalic, succinic, and salicylic acids are investigated. The reaction of the triethanolammonium salts with silver nitrate is studied, and the structure of the reaction product is determined.

N,N′-Bis(hydroxymethyl)thiourea reacted with propane-1,3-diamine at a molar ratio of 2 : 1 to give 5,5′-propane-1,3-diylbis(1,3,5-triazinane-2-thione), whereas 1,3,5,7,11,13,15,17-octaazatricyclo[15.3.1.17,11]-docosane-4,14-dithione was obtained in the reaction with equimolar amounts of the reactants. Tricyclic product was also formed in the three-component condensation of thiourea with formaldehyde and propane-1,3-diamine at a ratio of 1 : 3 : 1. The reactions of N,N′-bis(hydroxymethyl)thiourea with ethane-1,2-diamine (2 : 1) and of thiourea with formaldehyde and butane-1,4-diamine (1 : 2 : 1) afforded 5,5′-(ethane-1,2-diyl)bis(1,3,5-triazinane-2-thione) and 5,5′-(butane-1,4-diyl)bis(1,3,5-triazinane-2-thione), respectively.

By X-ray diffraction the crystal and molecular structure of iodoprotatrane (tris(2-hydroxyethyl)ammonium iodide I[HN(CH2CH2OH)3]+ (IP) at 120 K and 293 K is determined. The IP cation, as in all protatranes, has the endo conformation. The N-H bond is surrounded by three CH2CH2OH groups. The stability of this configuration is explained by the intramolecular trifurcated inductive interaction with three oxygen atoms through the space of the nitrogen atom. In the IP crystal packing, each iodine anion is linked by three strong OH...I (2.63 Å) and three weak I...H (3.13 Å) hydrogen bonds with six cations from the CH2N group. This indicates a greater nucleophilicity of the iodine atom.

By X-ray diffraction the crystal and molecular structure of N-methyl-bis(2-hydroxyethyl)ammonium (4-chlorphenylsulfonyl)acetate 4-ClC6H4SO2CH2COO−·CH3N+H(CH2CH2OH)2 synthesized by the interaction of (4-chlorphenylsulfonyl)acetic acid with N-methyl-bis(2-hydroxyethyl)amine is studied.

It was shown by the method of powder X-ray diffraction analysis that in the crystalline state the product of the reaction of thiourea with chloroacetic acid in water, (carbamimidoylsulfanyl)acetic acid, existed in the zwitter-ion tautomeric form. The structure consists of virtually planar infi nite layers normal to the c axis of the unit cell which are bound by van der Waals interactions. The layers are formed by infi nite rows elongated along the b axis of the unit cell consisting of materially planar zwitter-ionic molecules linked by strong bifurcated hydrogen bonds. The results of quantum-chemical calculations by PM6 method are in agreement with the XRD results: whereas an isolated molecule exists in nonzwitter-ionic tautomeric form, in the crystal only the zwitterionic tautomer is present.

By X-ray diffraction the crystal and molecular structure of N-(1-silatranylmethyl)phthalimide (SMP) is determined. The coordination polyhedron of the silicon atom in SMP, as in all silatranes, is a trigonal bipyramide; the phthalimide cycle is planar. The data presented indicate that the silatranylmethyl group almost does not affect the geometry of the phthalimide moiety.

The crystal and molecular structure of a 1-(1-silatranylmethyl)-3,5-dimethylpyrazole complex with zinc dichloride (I) is determined by XRD. The coordination polyhedron of the zinc atom is a tetrahedron formed by two covalent Zn-Cl bonds and coordination Zn ← N and Zn ← O bonds. Compound I is the first example of how an endocyclic oxygen atom of the silatranyl fragment participates in the coordination of the metal atom with the formation of a six-membered heterocycle.

Two polymorphic modifications of N-methylbis(2-hydroxyethyl)ammonium hexafluorosilicate (AHFS) crystallize in monoclinic symmetry. The independent part of the unit cell of the low temperature modification contains two cations and an anion. The cell volume is two times smaller in the high temperature modification, the [SiF6]2- anion being disordered. In both modifications of methylbis(2-hydroxyethyl)ammonium hexafluorosilicate (HOCH2CH2)2HN+[SiF6]2-, the [SiF6]2- anion and the (HOCH2CH2)2HN+CH3 cation are linked by F…H—O hydrogen bonds. The silicon atom polyhedron in the anion is a tetragonal bipyramid; the coordination polyhedron of the nitrogen atom in the cation is a tetrahedron.

The synthesis and determination of the crystal and molecular structure of the binuclear complex fu-4,4′-bipyridyl-bis-[trans-C,0-nitrate-2-(2′-thienyl–3-ido)pyridine-palladium] is described (C28H20N6O6Pd2S2: a = 12.3914(11) Å, b = 9.8929(7) Å, c = 12.4058(12) Å, α = 90(0)β, ß = 105.440(40)α, γ = 90(0)α, V = 1465.9(0) Å3, monoclinic symmetry, P2 1/n (14), Z = 4, d x = 1.843 g/cm3 ). The pyridine rings of 4,4′-bipyridyl are shown to be in the orthogonal position with respect to the coordination planes of palladium centers both in the solid state and solution

3-tert-Butyl-6-(methylsulfanyl)-1,2,3,4-tetrahydro-1,3,5-triazine hydroiodide enters into the amine exchange reaction with glycine and β-alanine in aqueous solution. The final exchange products are [4-(methylsulfanyl)-5,6-dihydro-1,3,5-triazin-3-ium-1(2H)-yl] acetate and 3-[4-(methylsulfanyl)-5, 6-dihydro-1,3,5-triazin-3-ium-1(2H)-yl] propanoate, respectively, crystallizing together with t-butylamine hydroiodide from aqueous or aqueous alcoholic solutions as ion associates, which also can be detected in solution in DMSO-d 6. [4-(Methylsulfanyl)-5,6-dihydro-1,3,5-triazin-3-ium-1(2H)-yl] acetate can be extracted directly from the reaction mixture after carrying out the amine exchange in aqueous isopropanol or 95% ethanol, as well as by “recrystallization“ of its associate with tert-butylamine hydroiodide from aqueous isopropanol.

The synthesis and determination of the crystal and molecular structure of the binuclear complex fu-4,4'-bipyridyl-bis-[trans-C,0-nitrate-2-(2'-thienyl-3-ido)pyridine-palladium] is described (C28H20N6O6Pd2S2: a = 12.3914(11) , b = 9.8929(7) , c = 12.4058(12) , alpha = 90(0)beta, = 105.440(40)alpha, gamma = 90(0)alpha, V = 1465.9(0) (3), monoclinic symmetry, P2 (1)/n (14), Z = 4, d (x) = 1.843 g/cm(3) ). The pyridine rings of 4,4'-bipyridyl are shown to be in the orthogonal position with respect to the coordination planes of palladium centers both in the solid state and solution.

Zinc di-(4-chlorphenylthioacetate) dihydrate (4-ClC6H4SCH2COO)2Zn·2H2O (ZTD) is obtained in the reaction of protatrane 4-chlorphenylthioacetate 4-ClC6H4SCH2COO s- 2 ·N+H(CH2CH2OH)3 with zinc dichloride (ZnCl2) in aqueous alcohol. X-ray diffraction is used to study the crystal structure of ZTD and compare it with related compounds. All intermolecular O…O contacts of the neighboring zinc polyhedra are short in ZTD molecules. Apparently, the short intermolecular O…O contacts cause distortions of the octahedral environment of the zinc atom.

The crystal and molecular structure of N-(trifluorosilylmethyl)glutarimide has been determined by X-ray diffraction. The independent part of the unit cell of the single crystal contains two molecules that differ in the conformation of the glutarimide heterocycle. The coordination polyhedron of the silicon atom in them is a trigonal bipyramid. The bond lengths and angles in these molecules are compared with those in the crystal structures of related compounds.