目的：分析研究对帕金森病患者采用美多巴和联合普拉克索的治疗效果，为其临床治疗提供新的思路及理论支持。方法选取2013-06—2015-12在我院治疗的100例帕金森病患者进行分组研究，随机分为观察组与对照组各50例，对照组仅采用美多巴治疗，观察组使用美多巴和联合普拉克索治疗，观察2组治疗效果、治疗前后汉密顿抑郁量表评分和不良反应发生情况。结果观察组治疗总有效率为94.0％，对照组为78.0％，组间比较差异有统计学意义（P＜0.05）；治疗前2组患者汉密顿抑郁量表评分相比，差异无统计学意义（P＞0.05）；从治疗1周后开始，观察组汉密顿抑郁量表评分均优于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率6.0％与对照组的10.0％，差异无统计学意义（P＞0.05）。结论采用普拉克索联合美多巴治疗帕金森病患者疗效确切，能够有效改善患者抑郁状态，使患者拥有健康治疗心态，对提高患者治疗效果和生活质量具有重要意义，不良反应发生率较低，安全性较高，具有一定临床价值，值得推广运用。

目的 了解抑郁障碍的流行病学.方法结合广东市调研结果,查阅文献,对抑郁障碍的研究现状进行分析.结果 抑郁障碍的易患因素有遗传因素、社会文化因素、应激性生活事件和内分泌因素等.结论抑郁障碍的诊断标准尚未统一,应加强全民对精神科疾病的认识.

Objective: To assess the efficacy of Toronto clinical scoring system(TCSS),Michigan neuropathy screening instrument(MNSI) and neuropathy symptom score/neuropathy disability score(NSS/NDS) in the diagnosis of diabetic peripheral neuropathy.Method: Using the results of the specificity,sensitivity,Youden index,value of Kappar,the ROC curve and accuracy of the examinations were analyzed.Results: TCSS or MNSI had a higher consistency with the nerve conduction velocity examination(P0.05)than NSS/NDS(P0.01).TCSS or MNSI had a higher accuracy(Az=0.829 or 0.793),but NSS/NDS had a lower accuracy(Az=0.563).NSS/NDS does not apply to clinical DPN screening and diagnosis,MNSI suitable for outpatient service inspection,TCSS suitable for hospitalized patients.

10.3969/j.issn.1674-4985.2013.17.061

Objective Using digital subtraction angiography (DSA) in patients with ischemic cerebral vascular disease interventional diagnosis, analysis of endovascular stenting interventional therapy of ischemic cerebrovascular disease clinical curative effect. Methods From 2002 January to 2011 year during November in our hospital 100 cases of ischemic cerebral vascular disease patient as the research object, using DSA to carry on the intervention diagnosis and interventional treatment of selected, with 64 cases of angioplasty and operation treatment, observation of DSA diagnosis, analysis of interventional therapy effect and the occurrence of adverse reaction. Results 100 cases of ischemic cerebral vascular disease in patients with cerebral vascular and head and neck vascular lesions in 76 patients, 84 diseased arteries. 64 cases of angioplasty and stenting in patients underwent successful placement of a stent, 100%success rate, blood vessels are different degree expansion occurred in 8 cases, heart rate slowing down and other adverse reactions. Conclusion For ischemic cerebrovascular disease by DSA interventional diagnosis, for interventional therapy to improve evaluation based on. Stent angioplasty is an effective intervention method; it has good clinical effect in the treatment.

对符合脑卒中后抑郁(post stroke depression,PSD)诊断的60例患者给予5-羟色胺再摄取抑制剂(SSRI)氟西汀治疗,疗程为3个月.在治疗后1,2,3个月后分别用减分率判断疗效.结果治疗后第1个月痊愈7例,显著进步14例,进步32例,无效7例;第2个月痊愈23例,显著进步30例,进步5例,无效2例;第3个月痊愈46例,显著进步12例,进步1例,无效1例.治疗过程中胃肠道不适2例,失眠6例.

目的研究脑卒中后的抑郁障碍及抗抑郁药物对神经功能康复的临床疗效.方法应用抑郁自评量表从脑卒中急性期患者中筛选出有抑郁障碍者268例,分为治疗组和对照组,两组治疗前后用抑郁量表(CES-D)和脑卒中临床神经功能缺损程度评分标准分别评定患者抑郁障碍的严重程度和神经功能缺损程度.结果脑卒中患者CES-D 20项评定总分以基底核和度质受损者较高,总分＞25者,占51.9%;与神经功能缺损程度评分呈明显正相关;盐酸多塞平治疗后神经功能缺损程度显著低于治疗前,低于对照组;治疗组临床疗效显著高于对照组(P＜0.05).结论脑卒中后抑郁障碍与脑卒中部位和神经功能缺损程度有关,抗抑郁治疗可提高神经功能康复的疗效.

肺血栓栓塞症(PTE)曾被认为是少见病而极少被关注,但近年研究发现,PTE已经成为继肿瘤和心血管疾病之后的居第三位的致死性病变,正日益受到医学界的普遍关注.本文回顾性分析1999年7月至2003年7月我科收治的脑卒中病人在住院期间合并肺栓塞的病例12例,以提高对该病认识.