Objective Peripancreatic arterial aneurysms (PAAs) are rare but associated with a high risk of rupture and significant mortality. This study aims to evaluate the safety and efficacy of endovascular management for PAAs, focusing on technical strategies and midterm outcomes. Methods A single-center retrospective analysis was conducted on a study cohort of 26 patients with PAAs treated consecutively between June 2014 and March 2025. Endovascular therapy was prioritized, with open repair reserved for anatomically complex cases. Technical success, procedural details, and follow-up outcomes were analyzed. Results Among 29 aneurysms in 26 patients, 15 were located at the gastroduodenal artery–superior pancreaticoduodenal artery (GDA-SPDA) and 14 were at the superior mesenteric artery–inferior pancreaticoduodenal artery (SMA-IPDA). Endovascular therapy achieved primary technical success in 88.5% of cases. Two patients failed endovascular access via both the CA and SMA. Another had a vascular variant creating a high risk of splenic ischemia upon embolization, and a fourth had an aneurysm involving critical duodenal branches. Three of these four patients underwent successful open surgical repair. Sac-only embolization was performed in 63.6% of cases to preserve collateral flow. Access routes were largely determined by aneurysm location, with SMA for SMA-IPDA aneurysms and celiac artery (CA) for GDA-SPDA aneurysms ( p < 0.001). Concomitant celiac revascularization was avoided in most cases. At a median follow-up of 48 months, aneurysm recurrence and restenosis rates were 4.0% each, with no coil migrations or ischemic complications. Conclusion Tailored endovascular strategies guided by aneurysm anatomy and collateral circulation yield high technical success and favorable midterm outcomes without routine celiac revascularization. Endovascular therapy is a safe and effective first-line approach for PAAs, with open repair reserved for complex anatomies.

INTRODUCTION:Acne vulgaris is a prevalent dermatological condition characterized by the involvement of Cutibacterium acnes, inflammation, and follicular hyperkeratinization, among other factors. Curcumin, a polyphenolic compound derived from turmeric, exhibits multifaceted anti-inflammatory and antibacterial properties. This review aims to elucidate its mechanisms of action, evaluate preclinical and clinical evidence, explore formulation strategies, and identify research gaps. METHODS:A comprehensive literature search was performed in the PubMed database, covering the period from its inception to March 2026. The search strategy incorporated a combination of keywords and Medical Subject Headings (MeSH) terms pertinent to curcumin (e.g., "curcumin," "turmeric"), acne (e.g., "acne vulgaris," "Cutibacterium acnes"), and related mechanisms and applications (e.g., "anti-inflammatory," "drug delivery systems"). The inclusion criteria encompassed original research articles, clinical trials, and systematic reviews published in peer-reviewed journals with full-text availability in English. RESULTS:Curcumin demonstrates multi-target anti-inflammatory properties by inhibiting critical pathways involved in the pathogenesis of acne and exhibits significant antibacterial activity against Cutibacterium acnes. Its efficacy is notably enhanced when utilized in conjunction with innovative delivery systems. Preclinical studies have validated its favorable safety profile, while clinical trials have indicated preliminary efficacy. CONCLUSION:Curcumin demonstrates the ability to concurrently target multiple pathogenic pathways in acne. Emerging delivery systems appear promising for addressing bioavailability challenges, and their favorable safety profile positions curcumin as a promising adjunctive treatment for acne vulgaris. Future research should prioritize conducting large-scale, randomized controlled trials with extended follow-up durations, standardized formulations, and comprehensive pharmacokinetic evaluations to establish dose-response relationships, thereby facilitating clinical translation.

Visceral arteries, including the celiac artery, superior mesenteric artery, and renal arteries, play a critical role in supplying blood to abdominal organs. Lesions affecting these arteries can be classified into two categories: primary visceral artery pathologies and secondary involvement due to aortic diseases, sometimes leading to serious complications such as ischemia, organ failure, and rupture. Computational modeling approaches have emerged as a valuable tool for analyzing complex hemodynamics in artery diseases. This review provides a critical overview of computational fluid dynamics (CFD) studies on lesions of or involving visceral arteries. CFD could help understanding how biomechanical forces contribute to the development and growth of aneurysms, stenosis, and dissections, as well as predicting the risk of thrombosis, restenosis, and graft failure after endovascular repair of aortic lesions involving the visceral branches. Significant challenges remain, including model simplifications, the lack of patient-specific boundary conditions, and inadequate clinical imaging data due to the complex and individualized anatomy of visceral arteries. Advancements in fluid-structure interaction modeling, real-time hemodynamic data acquisition from imaging modalities, and machine learning-based image segmentation are expected to enhance simulation accuracy and clinical relevance. CFD has the potential to refine the diagnosis and treatment of visceral artery diseases and improve clinical outcomes.

Circular RNAs (circRNAs) are a type of endogenous noncoding RNAs with covalently looped structures. Compared with other noncoding RNAs, circRNAs have the characteristics of stable structures, high abundance and tissue-specific expression. Recent studies have demonstrated that circRNAs can act as sponges, decoys and scaffolds for microRNAs and proteins, and play an important role in skin tumors. This review summarizes recent advances in the functions and mechanisms of action of circRNAs in common skin tumors, in order to understand the way in which they affect skin tumors, and to assess the value of further research on them.

BACKGROUND:Carotid body tumor (CBT) is a rare type of paraganglioma in head and neck region, with a high risk of surgical bleeding and nerve damage. Here we applied a new imaging tool termed "Flight Plan for Embolization" (FPFE) technique to better identify tumors' feeding arteries so that better dissection and bleeding control can be made to improve surgical outcomes. METHODS:One 55-year-old female and one 67-year-old male patient presented to our hospital with an asymptomatic CBT on the right and left neck, respectively. Surgical resection was proposed due to the lesions' nature of being able to gradually enlarge to cause significant neurovascular invasion and even malignancy transformation. The two patients underwent a 3D-digital subtracted angiography (DSA) for tumors before surgery. With the FPFE technique, the blood supply source and intra-tumoral distribution of CBTs were clearly identified from the 3D-DSA data. RESULTS:Surgery was performed for the female and male patients at 17 and 3 days after the angiography, respectively. With the guidance of FPFE, we could easily identify and control feeding vessels of the lesions and resect CBTs with minimal bleeding and nerve damage. CONCLUSIONS:In our experience, "FPFE" technique can effectively identify CBTs' main blood supply source, and might help to improve the surgical treatment by providing better bleeding control and clearer surgical field.

Several studies have reported gender-based differences in prognosis following open surgery repair (OSR) and endovascular therapy for treating aortic aneurysms. However, the blood transfusion rates for both gender and the predictors of intraoperative transfusion during OSR for Descending Thoracic and Abdominal Aortic Aneurysms (DTAA) remain uncertain. Data of Patients with DTAA who underwent OSR at our center between August 2002 and December 2021 were retrospectively collected. Specific aneurysms and preoperative anemia were excluded from the study. Transfusion of blood products was recorded. Logistic regression analyses were conducted to identify the factors significantly related to transfusion. An adjusted analysis of the association between gender and red blood cell (RBC) transfusion was performed. A total of 82 patients were included, of whom 23 were female. Forty-six DTAAs received intraoperative RBC transfusions. The transfusion rates for male and female were 45.8

BackgroundAortic aneurysm is a potentially fatal condition. Although contemporary studies have established that this disease triggers an inflammatory response, reduces smooth muscle cells, and induces extracellular matrix remodeling, the involvement of inflammatory cells and associated signaling pathways in the progression and expansion of aneurysms is well-documented. However, clinical treatments utilizing anti-inflammatory therapies have proven ineffective.MethodsIn this study, we employed a classic mouse model of abdominal aortic aneurysm (AAA) to compare the cellular composition and functional phenotypes of normal and AAA cells within a comprehensive single-cell microenvironment.ResultsOur findings revealed distinct evolutionary pathways for both fibroblasts and macrophages, leading to the identification of specific fibroblast subtypes (Fib_Apoc1+/Fabp4+ and inflam-Fib1) and a macrophage subtype (Mac_TREM2). Cellular interactome analysis further reveals that fibroblasts and macrophages may play a certain synergistic role in the development of AAA. This study provides a comprehensive characterization of the transcriptional landscape of AAA and identifies novel therapeutic targets.

OBJECTIVE:The aim of this study was to assess the optimal thresholds of surgical intervention for Behcet's disease (BD) aortic or peripheral artery pseudoaneurysms. METHODS:This was a retrospective single-center study of 2138 patients with BD, including 96 patients with vascular BD (4.5%) with 151 pseudoaneurysms between January 2002 and December 2021. Factors associated with mortality were assessed using Cox regression model. The growth rate of each pseudoaneurysm was calculated based on available imaging data in a linear mixed effect model. RESULTS:Patients in the surgical group (2/56) had significantly lower aneurysm-related mortality than those in the medical treatment group (10/33) (χ2 = 10.34; P = .0013). Surgical intervention (P = .009) and diameter of BD pseudoaneurysm (P = .006) were independently associated with BD aneurysm-related mortality. Rapid growth of BD pseudoaneurysm was achieved once diameter exceeded 4.0 cm for aortic pseudoaneurysm, or 2.5 cm for peripheral artery pseudoaneurysm, accompanied with high risk of rupture (Overall rupture rate: BD aortic pseudoaneurysm, ≥4.0 cm vs <4.0 cm: 63.6% vs 15.4%; BD peripheral artery pseudoaneurysm, ≥2.5 cm vs <2.5 cm: 50.9% vs 0). CONCLUSIONS:This study verified the critical role of surgical intervention in reducing the mortality rate of patients with BD pseudoaneurysms. BD aortic pseudoaneurysms larger than 4.0 cm in diameter and peripheral artery pseudoaneurysms larger than 2.5 cm in diameter require prompt surgical intervention due to the remarkable increase in the growth rate and greater risk of rupture and death.

Objective To explore the prevalence and risk factors of carotid artery (CA) stenosis among subclavian steal syndrome (SSS) patients and to record their prognoses. Methods This observational study was retrospective. From January 2015 to October 2022, 169 patients were diagnosed with SSS. Among them, 51 combined with CA stenosis have surgical indications for both diseases. In this cohort, 24 were treated for subclavian artery (23 endovascular, 1 open), 12 for CA (6 endovascular, 6 open), and 5 for both (1 endovascular, 1 open, 3 hybrid). The primary end point was mortality, and the secondary end points were vessel re-stenosis and other complications. Patients were followed up through outpatient, online, or telephone. Results Compared with simple SSS, patients who suffered from both were older (60.51 ± 9.304 versus 66.69 ± 7.921, P < 0.001) and more males (57.6% versus 86.3%, P < .001). Besides, they presented a higher prevalence of hyperhomocysteinemia ( P = .015), diabetes mellitus ( P = .036), and CVA/TIA ( P = .036). No patient died within 30 days after surgery; four complications occurred (1 stroke, 1 hearing loss, 1 TIA, 1 infection). During a median follow-up of 37.6 months, two patients died without relation to the operation, three appeared in-stent restenosis, and one developed contrast nephropathy. Discussion This study observed and analyzed different intervention methods and their prognosis in SSS combined with CA stenosis patients, and due to the limited number of participants, more data support would be needed. Conclusions The management of SSS patients combined with CA stenosis is more challenging compared to simple SSS. Our research demonstrated different surgical methods and their prognosis.

INTRODUCTION:Cerebral hyper-perfusion syndrome (CHS) is a rare but severe complication after surgery of carotid artery related disease (with a varied incidence range of 0-25.7 %), while its association with carotid body tumour (CBT) surgery is unknown. This study aimed to investigate the incidence and risk factors of CHS-like symptoms after resection of CBTs. METHODS:This retrospective study included 152 CBT patients (165 operated tumours) who received surgery at Peking Union Medical College Hospital from March 2013 to December 2021 and had fully-available clinical records. Surgeries were performed by the several operation teams (around 4-5 teams during the study period) from the department of vascular surgery, of which the team leaders were all senior vascular surgeons who had full experience on CBT surgery. CHS-like symptom was determined based on clinical manifestation and its risk factors were identified by univariate and multivariate regression analyses. RESULTS:The mean age of this cohort was 44.2 ± 10.9 years and female patients represented 67.1 % (102/152). There were 13 (13/152, 10.5 %) cases receiving bilateral CBT resections, generating a total of 165 operated tumours. The median maximum diameter of the tumours was 3.5 cm (IQR: 2.5-4.8 cm), with 37 (22.4 %), 40 (24.2 %) and 88 (53.3 %) lesions being classified as Shamblin I, II and III, respectively. All CBTs were completely resected under general anaesthesia, with 51 patients undergoing balloon occlusion tests (51/152, 33.6 %) preoperatively and no preoperative embolization was performed. During surgery, 34 cases (34/165, 20.6 %) underwent intervention for internal carotid artery (ICA) and 43 cases (43/165, 26.1 %) underwent external carotid artery ligation. Among the 165 operations, 43 cases developed CHS-like symptoms after surgery (26.1 %, 43/165), of which 26 cases received dehydrant therapy due to severe symptoms (60.5 %, 26/43) and most cases developed symptoms within 48 h after surgery (90.7 %,39/43). Univariate analysis revealed that occurrence of CHS-like symptoms is significantly related with elevated post-operation immediate heart rate (HR) (P = 0.006), post-operation day 1 morning HR (P = 0.004), ICA intervention (P = 0.002) and postoperative new-onset hypertension (P = 0.02). Furthermore, ICA intervention (P = 0.008) and new-onset hypertension (P = 0.017) remained the independent risk factors for development of CHS-like symptoms in multivariate regression analysis. CONCLUSION:CBT excision is related to a significant incidence of postoperative CHS-like symptoms, of which intraoperative ICA intervention and post-operative new-onset hypertension are the independent risk factors, thus more attention and closer monitoring should be given on such patients so as to prevent life-threatening CHS-related cerebral complications.

Cutibacterium acnes biofilms are frequently identified in acne lesions and on implant surfaces contributing to bacterial resistance and subsequent treatment failure. While minocycline, a broad-spectrum tetracycline antibiotic, is a conventional therapeutic agent for C. acnes infections, its efficacy against biofilms remains unclear. This study employed an in vitro biofilm model to examine the effects of varying minocycline concentrations at different stages of biofilm formation. Using our established in vitro model of C. acnes early- and later-stage biofilms, we exposed the biofilms to different minocycline concentrations. Morphological changes were assessed visually, biofilm viability was measured via XTT assay, biofilm biomass was quantified by crystal violet staining, and three-dimensional structural alterations were analyzed using confocal laser scanning microscopy (CLSM). A low minocycline concentration (0.25 mmol/L) inhibited biofilm formation by reducing bacterial adhesion, whereas a higher concentration (> 4.0 mmol/L) eradicated mature biofilms and eliminated embedded bacteria. The study results demonstrate that minocycline effectively inhibits C. acnes biofilm formation, supporting our hypothesis regarding its inhibitory effects. Additionally, this study addresses a gap in existing research on minocycline’s impact on bacterial biofilms. Our findings also provide a reference for investigating minocycline’s effects on biofilms formed by other bacterial species. Future studies will focus on elucidating the molecular mechanisms underlying this phenomenon.

Acne scarring is a common consequence of acne vulgaris. Recently, there have been huge advancements in photoelectric therapies for scarring, leading to a growing body of literature on the efficacy and safety of these devices. However, interventional studies are hindered by the absence of standardized and validated outcome measures for acne scarring. In this article, we aim to review current grading modalities to assist clinicians in conducting acne scar research and therapies. PubMed and MEDLINE online databases were searched to identify acne scarring severity measurement tools. Each was classified into objective tools, subjective investigator-reported or patient-reported assessments and they were evaluated for reliability, sensitivity, validity and other important aspects. Objective instruments for assessing clinical efficacy in acne scarring show promise, especially PRIMOS, a three-dimensional imager with strong interrater reliability [intraclass correlation coefficient (ICC) > 0.90] and intrarater reliability (ICC > 0.96). Regarding subjective assessments, the Échelle d'Évaluation Clinique des Cicatrices d'Acné (ECCA) tool features the widest range of applications and shows acceptable performance. The original ECCA tool scored five out of eight points, while the adapted version achieved six out of eight points after combining three essential factors: reliability, sensitivity and validity. The Goodman and Baron Global Acne Scarring Grading System (GSGS) score also achieved a good score of seven out of eight. However, most scales demonstrated poor or moderate performance owing to the lack of reliability testing and evidence from independent assessment. Our conclusion is that PRIMOS stands out as a strong objective tool, whereas GSGS and adapted ECCA are the leading subjective scales with acceptable to strong performance. More importantly, there is the need for standardized scales, facilitating the pooling of results for systematic reviews, meta-analyses and clinical recommendations.

Acne is a common chronic inflammatory disease of the pilosebaceous unit. Transient receptor potential vanilloid 3 (TRPV3) is an ion channel that is involved in inflammatory dermatosis development. However, the involvement of TRPV3 in acne-related inflammation remains unclear. Here, we used acne-like mice and human sebocytes to examine the role of TRPV3 in the development of acne. We found that TRPV3 expression increased in the skin lesions of Propionibacterium acnes (P. acnes)-injected acne-like mice and the facial sebaceous glands (SGs) of acne patients. TRPV3 promoted inflammatory cytokines and chemokines secretion in human sebocytes and led to neutrophil infiltration surrounding the SGs in acne lesions, further exacerbating sebaceous inflammation and participating in acne development. Mechanistically, TRPV3 enhanced TLR2 level by promoting transcriptional factor p-FOSL1 expression and its binding to the TLR2 promoter, leading to TLR2 upregulation and downstream NF-κB signaling activation. Genetic or pharmacological inhibition of TRPV3 both alleviated acne-like skin inflammation in mice via the TL2-NF-κB axis. Thus, our study revealed the critical role of TRPV3 in sebaceous inflammation and indicated its potential as an acne therapeutic target.

Acne is a long-lasting inflammatory skin condition that impacts the sebaceous units of the hair follicles, affecting around 85-90% of the population. Due to the potential for permanent facial scarring and negative social consequences, as well as the limitations of conventional medications like drug resistance and difficulties following treatment plans, it's crucial to investigate non-pharmacological options for treating acne, among which radiofrequency(RF) shows distinct superiority. To assess the impact of RF in the management of acne vulgaris, we conducted a thorough examination of scientific literature (including clinical trials and scientific reviews) through electronic databases like MEDLINE and PubMed. Our analysis indicates that RF could be a viable substitute for acne treatment due to its notable effectiveness and minimal adverse effects.

BACKGROUND:The treatment of acne vulgaris is often challenging due to the antibiotic resistance frequently observed in Cutibacterium acnes (C.acnes), a prevalent bacterium linked to this condition.OBJECTIVE:The objective of this research was to examine the impact of curcumin photodynamic therapy (PDT) on the survival of C.acnes and activity of biofilms produced by this microorganism.METHODS:Following the Clinical and Laboratory Standards Institute (CLSI) guidelines, we assessed the drug sensitivity of 25 clinical C.acnes strains to five antibiotics (erythromycin, clindamycin, tetracycline, doxycycline, minocycline) and curcumin by implementing the broth microdilution technique. In addition, we established C.acnes biofilms in a laboratory setting and subjected them to curcumin-PDT(curcumin combined with blue light of 180 J/cm2). Afterwards, we evaluated their viability using the XTT assay and observed them using confocal laser scanning microscopy.RESULTS:The result revealed varying resistance rates among the tested antibiotics and curcumin, with erythromycin, clindamycin, tetracycline, doxycycline, minocycline, and curcumin exhibiting resistance rates of 72 %, 44 %, 36 %, 28 %, 0 %, and 100 %, respectively. In the curcumin-PDT inhibition tests against four representative antibiotic-resistant strains, it was found that the survival rate of all strains of planktonic C. acnes was reduced, and the higher the concentration of curcumin, the lower the survival rate. Furthermore, in the biofilm inhibition tests, the vitality and three-dimensional structure of the biofilms were disrupted, and the inhibitory effect became more significant with higher concentrations of curcumin.CONCLUSION:The results emphasize the possibility of using curcumin PDT as an alternative approach for the treatment of C.acnes, especially in instances of antibiotic-resistant variations and infections related to biofilms.

Background Selecting intervention strategies for renal artery aneurysms (RAAs) is challenging especially for those located at the vessel bifurcation. The relationship between the aneurysm and renal branches could not always be accurately viewed from traditional computed tomography angiography (CTA) images.Case presentation This study proposed a new method to investigate the anatomy and affected vessel branches of RAAs using automated software. Two patients with RAAs located at the renal artery bifurcation underwent Cone beam CTA (CBCTA) analysis. We sequentially coupled the "two-click AVA" function of Vessel IQ Xpress (GE Healthcare) with the "vascular tree extraction" function from FlightPlan for Embolization (GE Healthcare) to evaluate the relationship among the main renal artery, vessel branches, and aneurysms. The results showed that one patient had 1 out of 3 branches affected by the aneurysm, whereas the other's branches were all affected. Endovascular repair and open surgery were performed respectively based on the image analysis. Both patients recovered well at follow-up examination.Conclusions Based on CBCTA analysis, the combination use of the "two-click AVA" function of VesselIQ Xpress and FlightPlan for Embolization software could assist in aneurysm assessment and intervention choices for RAAs.

Purpose: Renal artery aneurysm (RAA) is a rare disease. This study proposed and evaluated a new classification for RAA to assist in surgical decision-making. Materials and Methods: Single-center data of 105 patients with RAAs from the vascular department of vascular surgery were collected retrospectively. A new classification scheme was proposed. Type I aneurysms arise from the main trunk, accessory branch, or first-order branches away from any bifurcation. Type II aneurysms arise from the first bifurcation with narrow necks (defined as dome-to-neck ratio >2) or from intralobular branches. Type III aneurysms with a wide neck arise from the first bifurcation and affect 2 or more branches that cannot be sacrificed without significant infarction of the kidney. Results: There was 50 (47.62%) type I, 33 (31.43%) type II, and 22 (20.95%) type III aneurysms. The classification assigned endovascular repair as first-line treatment (for type I or II), while open techniques were conducted if anatomically suitable (for type III). A kappa level of 0.752 was achieved by the classification compared with a level of 0.579 from the classic Rundback classification. Technical primary success was achieved in 100% and 96.05%, and symptoms were completely resolved in 100% and 84.85%, while hypertension was relieved in 84.21% and 72.92% of patients receiving open surgery or endovascular repair, respectively. No significant difference was observed for perioperative or long-term complications among the 3 classification types. Conclusion: The new classification proved to be a convenient and effective method for facilitating choice of intervention for RAAs. Clinical Impact This study proposed and evaluated a new classification scheme for renal artery aneurysms, which proved to be a convenient and effective method for facilitating surgical decision-making. Coil embolization was the first-line treatment if suitable, while aneurysm resection and reconstruction with vein graft were conducted for some complex lesions. The safety and efficacy of both open and endovascular methods were validated.

PURPOSE:This split-face randomized study compared the efficacy and safety between 1064-nm picosecond laser with fractionated microlens array (MLA) and 1565-nm nonablative fractional laser to treat enlarged pores. METHODS:Participants with enlarged facial pores were enrolled and underwent three consecutive sessions at 2-week intervals with either a 1064-nm picosecond laser with MLA or a 1565-nm nonablative fractional laser. Images were captured at each visit. Objective (pore number) and subjective assessments, including patient self-evaluations and quartile improvement scales, were used to evaluate the treatment efficacy. The pain levels and adverse effects were recorded at each subsequent visit. RESULTS:The participants were 3 men and 22 women with enlarged facial pores. At the initial and 2-month checkups after the last treatment, the pore numbers were significantly decreased bilaterally for both lasers. The respective quartile improvement scale scores for the 1064-nm picosecond and 1565-nm fractional lasers were 2.22 ± 1.06 and 2.14 ± 1.11, while those for patient self-assessment were 3.72 ± 0.74 and 3.68 ± 0.75. The pore number, quartile improvement scale score, and patients' self-assessments did not differ significantly between the two lasers. Treatment with the 1064-nm picosecond laser better reduced pain compared with the 1565-nm nonablative fractional laser (4.11 ± 1.33 vs. 4.83 ± 1.17). The occurrence of pigmentation did not differ significantly between the lasers. CONCLUSION:Both the 1064-nm picosecond laser with MLA and the 1565-nm nonablative fractional laser are viable options for treating enlarged pores, and showed comparable respective efficacies; however, the former was less likely to cause hyperpigmentation and was better tolerated.

Renovascular hypertension (RVH) is a primary cause of secondary hypertension, primarily driven by the activation of the renin-angiotensin-aldosterone system activation. Recently, growing studies suggested accessory renal artery (ARA) might also contribute to RVH. However, the treatment of ARA-related hypertension and whether to take interventional treatment lack consensus. Herein, we report two cases of ARA-related hypertension in our hospital. Imaging studies of both patients showed ARA stenosis. One patient had ARA occlusion well-compensated through tortuous collateral branches, achieving normal blood pressure by medical treatment alone. The other patient had ARA stenosis coexisted with main renal artery stenosis, and revascularization of both arteries led to a significant postoperative reduction in blood pressure. A literature review was conducted to summarize overall treatment strategies for ARA-related hypertension and clarify the relationship between ARA and hypertension. Recent research supported an association between ARA and hypertension. While medical therapy remains the first-line treatment for ARA-related hypertension, interventional procedures should be considered for patients whose blood pressure remains uncontrolled despite conservative management.