Objective To investigate the shock reasons for percutanuous transhepatic puncture biopsy directed by Color Doppler Ultrasound(CDU) in 24 hours.Methods One thousand patients who were operated on percutanuous transhepatic puncture biopsy directed by CDU from March 2006 to August 2007,were observed continuously before and 24 hours after PTCB and the results were analysed,retrospectively.Results The degree of psychological(nervous) tension were positively correlated with the incidence of shock and associated with the patients' somatotypes,professions and educational backgrounds.Conclusions Patients who were nervous before or during the operation would be paied attention to and the shock should be avoided.

Aim: To explore the effects of the neuroendocrinologic side effects caused by risperidone on the emotion and life quality of schizophrenic women. Methods: Fifty-eight female schizophrenic patients, aged 18-43 years old, with normal menstrual cycle before the initial treatment of antipsychotics, were involved in the cross-sectional study. After treated with risperidone alone for at least 6 months, the levels of prolactin, cortisol, estradiol, testosteone and thyroid stimulating hormone of serum as well as the basic body temperature were measured. The Brief Psychiatric Rating Scale (BPRS), Hamilton Anxiety Scale(HAMA), Hamilton Rating Scale for Depression (HAMD) and Generic Quality of Life Inventory -74(GQOLI-74) were examined. Results: In the 58 patients, 14 were with regular menstrual cycle, 23 with irregular menstrual cycle and 21 with amenorrhea, 44 of them were suffering from galactorrhea and 53 of them with estradiol ≤50.0 ng/L. The serum prolactin level in the study group(median 98.0 μg/L) was significantly higher than that in the control group (median 9.3 μg/L) (U = 17.0, P < 0.01). The testosteone level in the study group [ (1.1 ± 0.4) μg/L] was significantly higher than that in the control group[ (0.5 ± 0.3) μg/L] (t = 7.32, P < 0.01). There were no significant differences in cortisol and thyroid stimulating hormone levels between the two groups(P > 0.05). There was a significant difference in the despair factor of HAMD (F = 3.71, P < 0.05) and the factor of sleep and energy of the GQOLI-74 among the groups with regular menses, irregular menses and amerorrhea(F = 3.968, P < 0.05). The spearman correlation analysis showed that there was no significant relation between the levels of hormones and anxious and depressive factors of the scales (r = -0.132 - 0.258, P > 0.05). Conclusion: The endocrine side effects caused by risperidone may have negative effects on the emotion and life quality of female patients with schizophrenia.

目的探讨利培酮对女性精神分裂症患者神经内分泌的影响.方法对58例女性精神分裂症患者在利培酮治疗至少6个月后,检测性激素水平及利培酮血药浓度.并与30名健康女性进行对照分析.结果研究组催乳素(PRL)、睾酮水平均显著高于对照组(P＜0.01),而雌二醇、孕酮水平则显著低于对照组(P＜0.01).溢乳组PRL水平显著高于无溢乳组(P＜0.01),ROC曲线显示,当PRL≥98.0 μg/L时溢乳的危险性升高.结论①利培酮治疗后可见血催乳素、睾酮水平升高,雌二醇、孕酮水平降低;②催乳素≥98.0 μg/L时发生溢乳的危险性升高.探讨利培酮对神经内分泌的影响还需进一步做前瞻性研究.