Myb-like, SWIRM and MPN domains 1 (MYSM1), a histone H2A deubiquitinase (2A-DUB), is essential for hematopoietic development and immune regulation, and has recently been found to be involved in modulation of several tumors, including breast, colorectal, and prostate cancer. However, its role in cervical cancer (CC) pathogenesis remains unexplored. Based on public transcriptome datasets including The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Human Protein Atlas (HPA), we profiled the pan-cancer expression landscape of MYSM1 and its clinical relevance in CC. Survival analysis was validated using the TCGA, GSE44001, and our internal 44-case clinical cohort. A series of in vitro and in vivo functional assays were performed to explore the regulatory effects of MYSM1 on CC malignant behaviors and autophagy. ChIP-Seq, transcriptomic profiling, and correlation analysis were applied to screen potential downstream target genes of MYSM1, while functional enrichment analyses, e.g., Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA) and cellular rescue assays were conducted to verify the MYSM1-inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)-autophagy regulatory axis. Mendelian randomization (MR) analysis was further performed using the GWAS Catalog datasets to evaluate the genetic association of MYSM1 and ITPR1 with CC susceptibility, combined with validation in paired clinical CC specimens. MYSM1 is aberrantly expressed across pan-cancer, and profoundly downregulated in CC tissues. High MYSM1 expression is positively correlated with benign clinicopathological characteristics of CC patients, consistent with its tumor-suppressive role. Functional experiments confirmed that MYSM1 restrains CC cell proliferation, migration, and invasion in vitro and in vivo, and significantly promotes cellular autophagy. Mechanistically, ITPR1 was identified as a key downstream gene epigenetically activated by MYSM1. ITPR1 functions as an autophagy inducer and is associated with favorable clinical phenotypes in CC, thereby mediating the anti-tumor effects of MYSM1, further forming a MYSM1-ITPR1-autophagy regulatory axis. Both MYSM1 and ITPR1 were downregulated in 44 paired CC tumor tissues, possessing diagnostic and prognostic potential for CC. MR analysis revealed a modest suggestive genetic association between genetically predicted MYSM1 and ITPR1 expression and CC susceptibility. MYSM1 is an autophagy promoter and can exert tumor-suppressive effects on CC primarily through epigenetic activation of ITPR1. Axis of MYSM1-ITPR1-autophagy shows diagnostic and prognostic implications, and may be developed as a potential therapeutic target for CC in clinic.

The clinical relevance of mitochondrial RNA modification (MRM) in colorectal cancer (CRC), particularly its value for prognostic stratification, has not been fully defined. We integrated bulk transcriptomic profiles, machine learning-based model screening, single-cell analysis, and experimental validation to identify MRM score-associated prognostic genes and construct a CRC risk model. Seven CRC-related prognostic genes were selected: SPARCL1, MGP, PRELP, PALMD, TNS1, ARHGEF25, and PTGIS. These genes were incorporated into a risk signature with favorable prognostic performance, as supported by nomogram-based assessment. Gene Set Enrichment Analysis indicated that cytokine-related processes may participate in CRC progression. TNS1 showed the strongest positive association with natural killer cells (cor = 0.784, P < 0.05) and the strongest inverse association with type 17 T helper cells (cor = -0.279, P < 0.05). Database-based screening predicted 113 candidate compounds targeting CRC. Single-cell analysis further highlighted smooth muscle cells, epithelial cells, endothelial cells, T cells, and B cells as major cellular populations of interest. SPARCL1, MGP, PRELP, and PALMD increased during both early and late B cell maturation, whereas TNS1 and ARHGEF25 were highly expressed across broader cellular contexts. In conclusion, SPARCL1, MGP, PRELP, PALMD, TNS1, ARHGEF25, and PTGIS may represent MRM score-associated prognostic markers in CRC and require further study.

Novel TPE-based metallacycles were developed as efficient supramolecular photosensitizers, offering new opportunities for optimizing photodynamic therapy and advancing its biomedical applications.

Perylenediimide (PDI) radical anions have been extensively investigated and applied in photothermal therapy. However, the current PDI radical anions show poor photothermal conversion efficiency owing to the intrinsic ambient instability and unfavorable aggregation of PDI units, restricting their subsequent practical application. Herein, an N-heterocyclic carbene (NHC) metallacycle was employed to fabricate a discrete pi-stacked PDI dimer (PDI 2), which was subsequently reduced to the PDI radical dimer (PDI 2 -RD) by glutathione (GSH). The well-defined dimer packing endows PDI 2 -RD with robust ambient stability over 30 days, suppresses the quenching of PDI radical anions, and facilitates intramolecular electron transfer. As a result, the PDI 2 -RD achieves a photothermal conversion efficiency of 84.9%, which is 13.1 times higher than that of the monomeric PDI radical anion under 808 nm laser irradiation. For in vitro and in vivo experiments, the GSH-induced PDI 2 -RD within tumor cells showed excellent photothermal therapeutic efficacy as well as good biocompatibility. This study presents an alternative strategy to develop stable and discrete radical dimers for efficient photothermal therapy.

Chronic wounds, particularly pressure ulcers (PUs), pose a persistent clinical challenge due to infection, oxidative stress, and impaired healing. To address these issues, we developed a smart hydrogel wound dressing based on a dynamic phenylboronate ester network formed between phenylboronic acid-modified hyaluronic acid (HA-PBA) and dopamine-modified hyaluronic acid (HA-DA). This network enables ROS/pH-triggered quercetin release: under inflammatory conditions (pH 5.5 or elevated H2O2), the boronate ester bonds cleave, releasing the antioxidant drug quercetin on demand. In addition, the polydopamine (PDA) components confer a PDA-mediated photothermal antibacterial effect; upon 808 nm near-infrared irradiation, the hydrogel rapidly kills >99% of both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli in vitro. In a mouse model of MRSA-infected pressure ulcer repair, treatment with this hydrogel plus mild photothermal therapy significantly reduced bacterial load, accelerated granulation tissue formation, promoted re-epithelialization, and enhanced angiogenesis, achieving similar to 90% wound closure within 14 days. This work demonstrates that integrating dynamic covalent crosslinking, stimuli-responsive antioxidant delivery, and photothermal antibacterial activity into a single platform offers a promising strategy for infected pressure ulcer management.

The development of efficient photosensitizers for photodynamic therapy (PDT) remains a significant challenge due to the limitations of aggregation-caused quenching (ACQ) in commonly used chromophores. Here, we present the design and synthesis of a tetraphenylethene-porphyrin hetero-faced molecular cage (1•8Cl-), where tetraphenylethene (TPE) with aggregation-induced emission (AIE) properties is covalently linked to porphyrin, which exhibits good photosensitivity but suffers from ACQ effects. The hetero-faced molecular cage is designed with a face-to-face configuration, facilitated by four p-xylylene linkers, ensuring precise spatial alignment of the TPE and porphyrin units. This cage-type molecular architecture not only enables the conversion of ACQ to AIE, but also populates the triplet state of porphyrin via efficient intramolecular energy and electron transfer owing to the favorable geometry. As a result, 1•8Cl- demonstrates excellent ability to generate reactive oxygen species (ROS) and binds nicotinamide adenine dinucleotide (NADH) in aqueous solution, catalyzing the rapid photocatalytic oxidation of NADH to its oxide form (NAD+). Utilizing ROS generation and the disruption of the intracellular redox balance of NADH, 1•8Cl- exhibits significant potential for effective photocatalysis-assisted PDT in hypoxic tumor environments. This study opens a new pathway for molecular design by combining molecular cage structures with photosensitizer functionality, enabling applications in fields such as photocatalysis and PDT.

BackgroundBowel sounds are a valuable indicator of monitoring and reflecting intestinal motility. Information about bowel sounds is significant for assessing physical condition. Short video-sharing platforms facilitate such information but must be validated regarding the quality and reliability of the content.ObjectiveThis study aimed to assess the reliability and quality of bowel sounds-related information available on Chinese short video-sharing platforms.MethodsA total of 132 video samples were collected on the three most popular Chinese video sharing platforms: TikTok, Bilibili, and WeChat. Each video was assessed by two independent physicians in terms of content comprehensiveness, quality (using the Global Quality Score) and reliability (using the DISCERN tool). Furthermore, comparisons were made across different video sources.ResultsOut of 132 videos analyzed, 78 (59.09%) were uploaded by medical professionals, including gastroenterologists, non-gastroenterologists, and clinical nutritionists, while 54 (40.91%) were shared by non-medical professionals such as science bloggers, nonprofit organizations and patients. Gastroenterologists-uploaded videos received the highest engagement, with median likes of 150 (IQR: 31–1,198), favorites of 90 (IQR: 19–412) and share of 50 (14–225). And in general, Medical professionals’videos generally showed higher engagement, particularly those by Gastroenterologists, compared to non-medical professionals. The median The GQS and modified DISCERN tool were used to assess video quality and reliability respectively, with medical professionals scoring higher on both metrics (z = 4.448, p < 0.001; z = 2.209, p < 0.05). GQS score and DISCERN score was 2 for bowel sounds videos analyzed in this study. Videos from gastroenterologists had the highest GQS scores, with a median of 3. However, the DISCERN score of gastroenterologists needs to be improved.ConclusionThe study shows that medical professionals generally provide better and more accurate results than non-professionals. Videos uploaded by clinical nutritionists offer more comprehensive health education and treatment options. To ensure public access to reliable information, it’s important to encourage medical professionals to produce the videos and also basic standards must be established.

With the global population aging and the rising prevalence of chronic diseases, the demand for real-time, accurate, and personalized health monitoring has become imperative. Rapid self-healing, stable adhesion, and environmental stability are important characteristics for a flexible sensor to achieve stable signal acquisition. In this study, we introduced a supramolecular elastomer (PGS-0.03U-CNTs-0.2PIL) composed of poly(glycidyl sebacate), ureido-pyrimidinone, carbon nanotubes, and poly(ionic liquid). The elastomer integrates hydrogen bonding, ion-dipole interactions and hydrophobic interactions, resulting in strong underwater adhesion (41.1 kPa), rapid self-healing. The synergistic properties of PGS-0.03U-CNTs-PIL surpass those of currently available self-healing and self-adhesive elastomers. As a strain sensor, PGS-0.03U-CNTs-PIL exhibited a wide monitoring range and excellent cyclic stability, which contributes to the precise monitoring of joint motion and Morse code transmission. Additionally, as a bioelectrode, it enables real-time electrocardiogram and electromyogram monitoring in wet and underwater environments, outperforming commercial electrodes. And PGS-0.03U-CNTsPIL was used to achieve the diagnosis of heart attack disease and the judgement of muscle fatigue. Furthermore, its strong adhesion, antibacterial properties, and biocompatibility promote the healing of infected incisional wounds in vivo, achieving almost complete recovery within 14 days. The exceptional properties of PGS-0.03UCNTs-PIL highlight its potential for future health monitoring and wound healing applications.

Abstract Background The goal of this study was to assess whether combining amide proton transfer (APT)-weighted MRI with the Prostate Imaging Reporting and Data System scoring system version 2.1 (PI-RADS V2.1) could increase diagnostic accuracy compared to PI-RADS V2.1 alone in predicting clinically significant prostate cancer (csPCa). Methods The present study retrospectively analyzed data from patients who underwent prostate magnetic resonance imaging(MRI) examinations from July 2022 to August 2023. All patients underwent T2-weighted imaging (T2WI), amide proton transfer (APT), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) MRI. Two radiologists independently examined the images. The independent samples t test or the Wilcoxon rank sum test was employed to investigate the statistical variance in the demographic and APT parameters of the two groups. We utilized receiver operating characteristic (ROC) curve analysis to assess the diagnostic accuracy of PI-RADS V2.1 and the combination model (APT-weighted signal values and PI-RADS V2.1). The comparison of the area under the curve (AUC)s were conducted using the Delong method. Results A total of 289 patients were eventually included in this study; 102 had csPCa, and 187 had either benign lesions or clinically insignificant prostate cancer (cisPCa). The APTmean, APTmax, and APTmin values were significantly different between the two groups in both the peripheral zone (PZ) and transition zone (TZ). The combined models were significantly more effective than the use of PI-RADS V2.1 alone for the whole gland and PZ, with areas under the curve (AUC)s of 0.874–0.883 compared to 0.803 and 0.885 compared to 0.798, respectively (P < 0.05). However, there was no substantial improvement in diagnostic accuracy when APT-weighted signal values were incorporated into PI-RADS V2.1 for the TZ, as the AUC increased from 0.791 to 0.865, with a P value of 0.202. Conclusion By incorporating APT-weighted signal values with PI-RADS V2.1, there was a notable improvement in the diagnostic accuracy of csPCa detection in both the whole gland and the PZ compared to PI-RADS V2.1 alone. However, there was no significant enhancement in terms of csPCa in TZ.

BACKGROUND:The surgical management of rectal cancer is continuously advancing, with a current emphasis on minimising the need for a permanent stoma. Understanding the risk factors influencing sphincter preservation is crucial for guiding clinical decision-making and optimising preoperative patient evaluation. AIM:To examine the risk factors influencing sphincter preservation in laparoscopic radical rectal cancer surgery. METHODS:A retrospective analysis of the demographics, preoperative and intraoperative data, and pathological findings of 179 patients with rectal cancer who underwent laparoscopic radical rectal cancer surgery at our hospital between January 2022 and December 2023 was conducted. These clinical data were compared between two groups: Patients with sphincter preservation and those without, categorised as the sphincter-preserved and sphincter-unpreserved groups, respectively. RESULTS:Of the 179 patients analysed, 150 were in the sphincter-preserved group and 29 were in the sphincter-unpreserved group. Tumour height was significantly greater in the sphincter-preserved group compared to the sphincter-unpreserved group. Conversely, elevated levels of carcinoembryonic antigen, carbohydrate antigen 19-9, and plasma D-dimer were significantly higher in the sphincter-unpreserved group. Significant differences were also observed between the two groups in terms of place of residence, presence of colonic polyps, neoadjuvant chemotherapy, preoperative radiotherapy, mucinous adenocarcinoma, nerve invasion, and tumour height. No significant differences were observed for other parameters. Logistic regression analysis identified colonic polyps, mucinous adenocarcinoma, nerve invasion, and tumour height as independent risk factors for sphincter preservation. CONCLUSION:Several risk factors influencing sphincter preservation in laparoscopic radical rectal cancer surgery were identified. These factors could be valuable tools for guiding clinical decision-making and optimising preoperative patient evaluations.

PURPOSE:To evaluate the added value of amide proton transfer-weighted (APTw) imaging to diffusion-weighted imaging (DWI) using histogram analysis for assessing pathologic complete response (pCR) in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NCRT). METHODS:Sixty-two patients with LARC were enrolled in this prospective study. Magnetic resonance (MR) examinations including APTw, DWI, and T2-weighted imaging (T2WI) were performed before NCRT. Based on histologic assessment, patients were divided into a pCR group or a non-pCR group. APTw and apparent diffusion coefficient (ADC) histogram features were compared between the two groups. Correlations between histogram parameters and tumor regression grading (TRG) categories were assessed using Spearman's correlation analysis. The predictive performances of six models (ADC alone, APTw alone, clincal factors, APTw + ADC, clinical + APTw, APTw + ADC + clinical) were evaluated using the areas under the receiver operating characteristic curve (AUC-ROC). RESULTS:The pCR group demonstrated significantly lower APTw histogram parameters (including the 85th, 90th, 95th, and 99th percentiles, standard deviation, variance, et al) and higher APTw-1st percentile, skewness, and minimum values vs. non-pCR group(all P < 0.05). Adding APTw imaging to DWI using histogram analysis significantly improved diagnostic performance for predicting pCR (AUC: 0.909) compared to DWI alone(AUC: 0.722, P < 0.05). The combined model (APTw + ADC + clinical) achieved the highest AUC of 0.963. Multiple APTw histogram parameters (e.g., higher percentiles) showed positive correlations with TRG categories (Spearman's ρ range: 0.43-0.65; all P < 0.05). CONCLUSION:Adding APTw imaging to DWI using histogram analysis significantly improves diagnostic accuracy for identifying pCR to NCRT in LARC patients compared to DWI alone.

The controlled generation and utilization of singlet oxygen ( 1 O 2 ) are crucial for its diverse applications but remain challenging due to its high reactivity and short-lived nature. Here, we report a box-shaped metallacage prepared via multicomponent coordination-driven self-assembly using tetrapyridyl perylene diimide (PDI) and tetracarboxylate anthracene as building blocks. Upon photo-irradiation, the PDI faces act as photosensitizers to generate 1 O 2 , which reacts with the anthracene pillars to form a peroxidized metallacage, where 1 O 2 is captured and stored as anthracene peroxides. Heating releases 1 O 2 quantitatively, restoring the original metallacage structure. Both states are stable at room temperature, as confirmed by X-ray diffraction. Additionally, photoinduced electron transfer (PET) from anthracene pillars to PDI faces quenches the emission of the metallacage, while oxidation of anthracene inhibits PET, yielding bright fluorescence for the peroxidized metallacage. This reversible emission change enables the metallacage to function as a “turn-on” fluorescence sensor for dissolved oxygen, with a detection limit of 1.1 × 10 −3 mg L −1 . This study demonstrates a metallacage that can generate, capture, store, and release 1 O 2 for oxygen sensing, offering insights for designing stimuli-responsive smart materials.

Chirality in confined nanospaces has brought some new insights into chirality transfer, amplification, and chiroptical properties. However, chirality switching, which is a common phenomenon in biological systems, has never been realized in confined environments. Herein, we report a type of hexagonal metallacages that shows good host–guest interactions with ethoxy pillar[5]arene and pillar[6]arene, as confirmed by single-crystal X-ray analysis. Importantly, when a chiral pillar[5]arene-based molecular universal joint (MUJ) is used as the guest, the host–guest complexation would drive the alkyl ring of the MUJ flip from outside to inside the cavity of its pillar[5]arene unit, which enables the configuration change along with the chirality inversion of the MUJ. Moreover, the host–guest complexation facilitates the chirality transfer from guests to hosts, giving circularly polarized luminescence to the system. This study provides a unique metallacage-pillararene recognition motif for the chirality switching of planar chiral pillararenes, which will promote the construction of host–guest systems with tunable chirality for advanced applications.

The occurrence of complications following radical gastrectomy for gastric cancer significantly impacts patients’ quality of life. Elderly patients are susceptible to postoperative complications. This study seeks to investigate the risk factors associated with Clavien-Dindo ≥IIgrade complications following radical gastrectomy for advanced gastric cancer in elderly patients, develop a nomogram risk prediction model, and validate its accuracy. Retrospective collection of clinical and pathological data was conducted on 442 elderly patients with advanced gastric cancer who underwent radical gastrectomy at Shaanxi Provincial People’s Hospital from January 2015 to December 2020. They were randomly divided into a training set (n = 310) and a validation set (n = 132) in a 7:3 ratio. The severity of postoperative complications was graded using the Clavien-Dindo classification system, resulting in two complication groups: Clavien-Dindo

AIM:Small bowel obstruction is a common condition that requires emergency surgery. Slow recovery of bowel function after surgery or the occurrence of one or more complications can exacerbate the disease and result in severe small bowel obstruction (SSBO), significantly impacting recovery. It is characterized by a failure to regain enteral nutrition promptly, requiring long-term intensive care. Therefore, it is necessary to identify factors that predict SSBO, to allow early intervention for patients likely to develop this condition.METHODS:Of the 260 patients who underwent emergency or elective surgery for small bowel obstruction between January 2018 and December 2022, 45 developed SSBO. The least absolute shrinkage and selection operator regression model was applied to optimize factor selection and multivariable logistic regression analysis was used to construct a predictive model. The performance and clinical utility of the nomogram were determined and internal validation was conducted. In addition, the effects of the Houpu Paiqi mixture on postoperative recovery were analyzed by comparing the clinical data of 28 patients who were treated with the mixture and 61patients who did not receive it.RESULTS:The predictors included in the prediction nomogram were age, peritonitis, intestinal resection and anastomosis, complications, operation time, Acute Physiology and Chronic Health Evaluation II score, white blood cell count, and procalcitonin level. The model had an area under the receiver operating characteristic curve of 0.948 (95% confidence interval: 0.814-0.956). Decision curve analysis demonstrated that the SSBO risk nomogram had a good net clinical benefit. In addition, treatment with the Houpu Paiqi mixture reduced postoperative exhaust time, postoperative defecation time, time to first postoperative liquid feed, and length of stay in hospital.CONCLUSIONS:We developed a nomogram that can assist clinicians in identifying patients at greater risk of SSBO, which may aid in early diagnosis and intervention. Additionally, we found that the Houpu Paiqi mixture promoted postoperative recovery.

BACKGROUND Prolonged postoperative ileus (PPOI) delays the postoperative recovery of gastrointestinal function in patients with gastric cancer (GC), leading to longer hospitalization and higher healthcare expenditure. However, effective monitoring of gastrointestinal recovery in patients with GC remains challenging because of the lack of noninvasive methods. AIM To explore the risk factors for delayed postoperative bowel function recovery and evaluate bowel sound indicators collected via an intelligent auscultation system to guide clinical practice. METHODS This study included data from 120 patients diagnosed with GC who had undergone surgical treatment and postoperative bowel sound monitoring in the Department of General Surgery II at Shaanxi Provincial People's Hospital between January 2019 and January 2021. Among them, PPOI was reported in 33 cases. The patients were randomly divided into the training and validation cohorts. Significant variables from the training cohort were identified using univariate and multivariable analyses and were included in the model. RESULTS The analysis identified six potential variables associated with PPOI among the included participants. The incidence rate of PPOI was 27.5%. Age ≥ 70 years, cTNM stage (I and IV), preoperative hypoproteinemia, recovery time of bowel sounds (RTBS), number of bowel sounds (NBS), and frequency of bowel sounds (FBS) were independent risk factors for PPOI. The Bayesian model demonstrated good performance with internal validation: Training cohort [area under the curve (AUC) = 0.880, accuracy = 0.823, Brier score = 0.139] and validation cohort (AUC = 0.747, accuracy = 0.690, Brier score = 0.215). The model showed a good fit and calibration in the decision curve analysis, indicating a significant net benefit. CONCLUSION PPOI is a common complication following gastrectomy in patients with GC and is associated with age, cTNM stage, preoperative hypoproteinemia, and specific bowel sound-related indices (RTBS, NBS, and FBS). To facilitate early intervention and improve patient outcomes, clinicians should consider these factors, optimize preoperative nutritional status, and implement routine postoperative bowel sound monitoring. This study introduces an accessible machine learning model for predicting PPOI in patients with GC.

To investigate a novel approach for establishing the transverse pedicle angle (TPA) of the lower lumbar spine using preoperative digital radiography (DR). Computed Tomography (CT) datasets of the lower lumbar were reconstructed using MIMICS 17.0 software and then imported into 3-matic software for surgical simulation and anatomical parameter measurement. A mathematical algorithm of TPA based on the Pythagorean theorem was established, and all obtained data were analyzed by SPSS software. The CT dataset from 66 samples was reconstructed as a digital model of the lower lumbar vertebrae (L3-L5), and the AP length/estimated lateral length for L3 between the right and left sides was statistically significant (P = 0.015, P = 0.005). The AP length of the right for L4 was smaller than that of the left after a paired t test was executed (P = 0.006). Both the width of the pedicle and the length of the pedicle (P2C1) were consistent with TPA (L3<L4<L5). There were no significant differences in TAN-TPA and DR-TPA compared with real TPA. The ICCs for the real TPA and DR-TPA within L3 showed good reliability, and the ICCs for the real TPA and DR-TPA within both L4 and L5 showed moderate reliability. Our novel approach can be considered a reliable way to determine the transverse pedicle angle from routine DR, and the width and length of the pedicle within lumbar DR should be considered to determine the length and trajectory of the screw during preoperative planning.

Aim: The occurrence of perioperative complications in patients with abdominal wall incisional hernia not only affects their postoperative recovery but also increases their financial burden and pain. Therefore, the influencing factors predicting the occurrence of perioperative complications in abdominal wall incisional hernia should be determined, so that clinicians can perform perioperative patient management and early interventions before surgery to reduce the occurrence of complications. Methods: This retrospective analysis included 212 patients with incisional hernia of the abdominal wall in Shaanxi Provincial People’s Hospital from January 2013 to December 2020. The least absolute shrinkage and selection operator regression model was applied to optimize factor selection, and multivariable logistic regression analysis was conducted to construct a predictive model. The performance and clinical utility of the nomogram were determined, and internal validation was conducted. Results: The prediction nomogram showed that abnormal preoperative pulmonary function, defect in the central region of the anterior abdominal wall, hernia size, and intraoperative bleeding were predictors of perioperative complications in abdominal wall incisional hernia. The model showed an area under the receiver operating characteristic curve of 0.771 (95% confidence interval: 0.687–0.767). Decision curve analysis demonstrated that the perioperative complications risk nomogram had a good net clinical benefit. Conclusions: We developed a nomogram to help clinicians identify abdominal wall incisional hernia patients who are at a greater risk of perioperative complications, which may aid in early intervention and reduce the incidence of perioperative complications in them.

The development of supramolecular hosts which can efficiently encapsulate photosensitizers to improve the photodynamic efficacy holds great promise for cancer therapy. Here, we report two perylene diimide-based metallacages that can form stable host–guest complexes with planar conjugated molecules including polycyclic aromatic hydrocarbons and photosensitizers (hypocrellin A). Such host–guest complexation not only prevents the aggregation of photosensitizers in aqueous environments, but also offers fluorescence resonance energy transfer (FRET) from the metallacage to the photosensitizers to further improve the singlet oxygen generation (ΦΔ = 0.66). The complexes are further assembled with amphiphilic polymers, forming nanoparticles with improved stability for anticancer study. Both in vitro and in vivo studies indicate that the nanoparticles display excellent anticancer activities upon light irradiation, showing great potential for cancer photodynamic therapy. This study provides a straightforward and effective approach for enhancing the photosensitivity of conventional photosensitizers via host–guest complexation-based FRET, which will open a new avenue for host–guest chemistry-based supramolecular theranostics.

Objective:To explore the occurrence and related risk factors of perioperative complications after radical gastrectomy in elderly patients with gastric cancer.Methods:The clinical and pathological data of 168 elderly patients with gastric cancer who underwent radical total resection in Shaanxi Provincial People’s Hospital from January 2015 to January 2020 were retrospectively collected. According to whether the perioperative complications occurred, the patients were divided into complication group and non-complication group. Postoperative complications were graded using Clavien-Dindo complication grading system, and the risk factors were determined by single factor and multiple factor logistic regression model. The predictive effect of the model was evaluated by the area under receiver operating characteristics (ROC) curve.Results:Postoperative complications occurred in 38 cases (22.62%), mainly pulmonary infection, anastomosis-related complications and incision-related complications, with 13 cases (34.21%) of Clavien-Dindo≥Ⅲ. Body mass index≥25 kg/m2, GNRI<92, complicated underlying diseases, upper gastric tumors, and TNM stage Ⅲ were independent risk factors for perioperative complications after radical gastrectomy in the elderly (P<0.05). The area under ROC curve value of its prediction model was 0.719 (95% CI: 0.623-0.815), and the prediction effect was good.Conclusions:There are many factors that affect the occurrence of complications during the perioperative period of radical total gastrectomy in elderly patients. In order to reduce the risk of complications and improve the prognosis, targeted intervention measures should be taken according to relevant risk factors.