Resveratrol is a natural plant estrogen which is similar to a steroid hormone produced by the body.Whether in the normal environment or in weightlessness,disease state and so on,it plays an impotant role on bone growth and bone protection.In the recent years,many researchs have focused on the effects of resveratrol on bone growth and bone protection,and it's mechanism were also highly concern worldwide.
【Objective】To determine the effect of Kuiyangsan on gastric ulcer(GU).【Method】Gastric ulcer in rat was established by ligating the pylorus of the rat.Fifty healthy male Wista rats were equally devided into five groups in random.High dose kuiyangsan group,middle dose kuiyangsan group,low dose kuiyangsan group were intragastrically fed with kuiyangsan(0.52,0.26,0.13 g/kg).Positive control group was intragastric fed with ranitidine 0.27 g/kg.Negative control group was intragastric fed with water.Intragastric fed was given every group for five days,at the fifth day,the rats were fasted for 24 h.At the seventh day of the pylorus of fifty GC rats were ligated after anaesth.Totle gastric acid,pepsin activity,ulcer exponent of rats were measured.【Results】The exponent of uler in high dose kuiyangsan group,middle dose kuiyangsan group,low dose kuiyangsan group and negative group.Ulcer index were 1.52± 0.41,2.13±0.56,2.76±0.75 and 5.01±0.82 respectively.Kuiyangsan group tended to be lower than negative group(P < 0.05).Gastric fluid volum of high dose kuiyangsan group,middle dose kuiyangsan group,low dose kuiyangsan group and negative group were 7.19± 0.14,8.51±0.43,9.34±0.61,501±0.82ml.Kuiyangsan group tended to be lower than negative group(P < 0.05).Totle gastric acid of high dose kuiyangsan group,middle dose kuiyangsan group,low dose kuiyangsan group and negative group’s were 86.08±7.19,90.94±19.2,96.17±13.7 and 126.8±17.5 mEq/L respectively.Kuiyangsan group tended to be lower than negative group(P < 0.05).Peptic activity of high dose kuiyangsan group,middle dose kuiyangsan group,low dose kuiyangsan group and negative group’s were 151.43±10.37,165.41±16.36,190.32±8.36 and 290.55±14.21 u/ml respectively.Kuiyangsan group tended to be lower than negative group(P < 0.05).【Conclusion】Kuiyangsan could reduce gastric acid volum,inhibit pepsin activity and prevent the occurrence of gastric ulcer.
【Objective】By comparing the curative effect and adverse events in treating calcanodynia by fumigation with Traditional Chinese Medicine and local blocking respectively,to explore the effective and convenient therapeutic treatment modality.【Methods】 130 cases of calcanodynia were randomily divided into two groups 65 in each.Cases of Group A were treated by fumigation with Traditional Chinese Medicine,and local blocking in Group B.Curative effect and adverse events were recorded and analyzed.【Results】There were no significant different in Group A and Group B on the effective rate of treatment(P 0.05).In group A,drug allergy was observed in 2 cases and mildly scalded in 3.In group B,incision infection was observed in 2 cases,hypodermic gore in 6 and subcutaneous nodules formation in 3.The statistical results show that the percentage of adverse events in group A was lower than that of group B(P 0.05).【Conclusion】The modality was effective,simple and dependable in treating calcanodynia with fumigation with Traditional Chinese Medicine.
蛋白激酶C (protein kinase C,PKC)是1977年在鼠脑的胞质成分中发现的一种依赖磷脂和钙的蛋白激酶,是细胞信号转导途径中重要的物质.PKC由多种具有不同生物学特性的同工酶组成,不同的PKC同工酶有着不同的酶学特性,在组织中的表达不同,在细胞信号传递中的作用也有着显著差别.近年来由对PKC整体功能的探索逐步转向到对PKC家族成员进行分别研究.本文就PKCα这种亚型的结构及其在正常组织和肿瘤组织的分布作一综述.
浮肩损伤(floating shoulder injury,FSI)是一种少见的肩部严重损伤,近年来,随着交通及建筑事业的迅猛发展,高能量外力造成FSI患者逐渐增多.