Hexane extract of licorice (Glycyrrhiza glabra L.) roots was obtained and investigated. Hydrocarbons, sterol ethers, triacylglycerides, free fatty acids, and free sterols were identified. The extract contains 70% neutral and 30% polar lipids. It is established that the lipid fraction of licorice roots is more effective than the analogous fraction of rosehip oil in stimulating the reparative regeneration of skin. In addition, this fraction also exhibits pronounced antiinflammatory and antiulcer effects, while being virtually nontoxic. Based on these results, the lipid fraction of licorice roots can be recommended as a parent substance for creating effective preparations in various medicinal forms.
Petroleum ether extract of licorice (Glycyrrhiza glabra L.) roots was obtained and investigated. Hydrocarbons, sterol ethers, triacylglycerides, free fatty acids, and free sterols were identified. The extract contained 70% neutral and 30% polar lipids. It is established that the lipid fraction of licorice roots are more effective than that of rosehip oil in stimulating the reparative regeneration of skin. In addition, this fraction also exhibits pronounced antiinflammatory and antiulcer effects. Based on these results, the lipid fraction of licorice roots can be recommended for creating and medicinal and cosmetic preparations.
ChemInformVolume 34, Issue 52 Natural Products Complexes of Glycyrrhizinic Acid with Antimicrobial Substances. R. M. Kondratenko, R. M. Kondratenko Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. A. Baltina, L. A. Baltina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorS. R. Mustafina, S. R. Mustafina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorA. F. Ismagilova, A. F. Ismagilova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. S. Zarudii, F. S. Zarudii Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorV. A. Davydova, V. A. Davydova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. V. Bazekin, G. V. Bazekin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. F. Suleimanova, G. F. Suleimanova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. A. Tolstikov, G. A. Tolstikov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author R. M. Kondratenko, R. M. Kondratenko Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. A. Baltina, L. A. Baltina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorS. R. Mustafina, S. R. Mustafina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorA. F. Ismagilova, A. F. Ismagilova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. S. Zarudii, F. S. Zarudii Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorV. A. Davydova, V. A. Davydova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. V. Bazekin, G. V. Bazekin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. F. Suleimanova, G. F. Suleimanova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. A. Tolstikov, G. A. Tolstikov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author First published: 04 December 2003 https://doi.org/10.1002/chin.200352229AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume34, Issue52December 30, 2003 RelatedInformation
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Glycyrrhizic acid (I) is an active component of licorice root extract obtained from plants of the Glycyrrhiza glabra L. and Glycyrrhiza uralensis Fisher species. The derivatives of acid I possess a broad spectrum of pharmacological properties, including antiinflammatory, antiulcer, antiallergic, antidote, antiviral, and some other types of activity [1]. Glycyrrhizic acid and its salts were recommended for the treatment of various forms of skin and liver cancer [2, 3] and are successfully used in the form of Stronger Neo-Minophagen C (SNMC) preparation for the therapy of patients with AIDS and hepatitis B [4, 5]. A purified glycoside component enters into the drug Clatraprostin (a veterinary preparation) and is used in the new medicinal forms of nonsteroidal antiinflammatory drugs and some other preparations [6, 7]. Previously [8] we proposed a method of obtaining purified glycyrrhizic acid (84 – 89%) from a commercial dry licorice root extract containing 26 – 28% of glycosides (available from the Urals Licorice Plant). Another commercial raw material that can be used for the synthesis of glycyrrhizic acid is glycyrram – a monoammonium salt of glycyrrhizic acid (available from the Chimkentbiofarm corporation). Glycyrram is an antiinflammatory drug used for the treatment of bronchial asthma, eczemas, and allergic dermatitis [9]. For the synthesis of pure glycyrrhizic acid from a commercial monoammonium salt, Volan and Dumazert [10] recrystallized the commercial product from acetic acid (AcOH) and ethanol, after which the purified glycoside was converted into a tripotassium salt (3K-salt) (II). Finally, salt II was converted into glycyrrhizic acid by acidification with an aqueous H 2 SO 4 solution.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.