目的 探讨帕金森病(PD)患者血清人软骨糖蛋白39(YKL-40)水平变化及其对患者病情的评估价值.方法 62例 PD患者(研究组)及60例健康者(对照组);检测两组研究对象血清YKL-40水平,采用蒙特利尔认知评估(MoCA)评价认知功能,采用帕金森综合评分量表(UP-DRS)评价患者PD病情,并分析三组间的关系.结果 研究组血清YKL-40水平明显高于对照组,MoCA 评分明显低于对照组(均 P<0.05);相关性分析显示,YKL-40与UPDRSⅡ评分、UPDRSⅢ评分均存在正相关(r=0.883,0.810;均P<0.01),YKL-40 与 MoCA评分存在负相关关系(r=-0.711,P<0.001).结论 PD患者血浆YKL-40水平较健康者显著升高,其水平与PD患者病情和认知功能密切相关,可诊断PD及判断病情.

Objective: To analyze changes in cysteine(Hcy),high sensitivity C reactive protein(hs-CRP) in type 2 diabetic patients with retinopathy according to the pathological characteristics of the disease and their clinical significance.Methods:A total of 153 cases of patients with diabetes were enrolled and divided into no retinopathy group(n=105 cases),background DR group(n=27 cases),and proliferation of DR group(n=21 cases),30 healthy volunteers were also enrolled as control group(n=30 cases).Disease course,and glucose level,hs-CRP and Hcy level were recorded and compared among these groups.Results: FPG,hs-CRP and Hcy levels in background DR group,proliferation of DR group(n=21 cases) were significant higher than that in control group or no retinopathy group(P0.05).In patients with retinopathy,Hcy were positively correlated with hs-CRP(P0.01).Conclusion: In patients with type 2 diabetic retinopathy,Hcy,hs-CRP were significant higher than that of healthy people,especially for patients with proliferative phase of DR.Combined detection of Hcy and hs-CRP can evaluate the severity of retinopathy in type 2 diabetes mellitus.

目的 探讨2型糖尿病合并冠心病或脑梗死患者炎性因子水平的变化及其在心脑血管病变中的作用.方法 选取49例2型糖尿病未合并大血管病变的患者纳入对照组,20例2型糖尿病合并大血管病变患者纳入观察组,选取同龄正常人群为正常组,比较三组人群的炎症因子水平以及颈动脉病变程度,分析其对糖尿病性大血管病变的影响.结果 观察组收缩压、FBG、TG升高最为明显,且合并颈动脉内膜增厚、粥样斑块形成及颈动脉狭窄比例最高.2型糖尿病患者sICAM-1、sVCAM-1、MCP-1及TNF-α均明显高于正常组(P＜0.05),而观察组上述指标与对照组也存在显著性差异(P＜0.05).结论 炎症因子在2型糖尿病合并心脑血管病变的患者中升高,在心脑血管病变中具有重要作用.