Hypothyroidism, a prevalent endocrine disorder characterized by insidious onset and prolonged progression, leads to metabolic slowdown and multiorgan dysfunction, significantly compromising patients' quality of life. While hormone replacement therapy improves most patients' serum thyroid function, it faces limitations, including individual response variations, lifelong medication requirements, and potential risks, with no reversal of existing tissue damage. In recent years, the mesenchymal stem cells (MSCs) and their derivatives have gained prominence in immunomodulation and regenerative medicine because of their abundant sources, low immunogenicity, potent paracrine effects, and multidirectional differentiation capabilities for tissue repair. Their unique advantages in modulating the immune microenvironment, promoting angiogenesis, reducing fibrosis, and stimulating endogenous cell regeneration offer novel strategies to overcome treatment bottlenecks in hypothyroidism and its complications, effectively repairing thyroid and multiorgan damage in animal models. This review synthesizes literature from the PubMed and Web of Science databases, incorporating relevant basic research and clinical trials. This study examined the systemic impacts of hypothyroidism, evaluated the experimental and clinical roles of the MSCs in thyroid tissue reconstruction and organ protection, and analyzed molecular mechanisms, including immune regulation, the antioxidant stress response, anti-apoptosis, and cellular function restoration. Clinical application potential is assessed alongside critical challenges such as standardized preparation, long-term safety, in vivo homing efficiency, and large-scale production.

The electrocaloric (EC) effect in ferroelectric materials has attracted extensive attention because of its high efficiency and potential applications in chip cooling. In this work, we successfully prepared a Pb (Sc0.25Ta0.25In0.25Nb0.25)O-3 (PSINT) ceramic via a solid-state reaction method with high-polar entropy. Next, the prepared ceramics were quenched at 1050 degrees C for various durations. The grain size of the quenched PSINT samples initially decreased to 0.39 mu m and then gradually increased to 0.61 mu m with a quenching time of 50 h. Xray diffraction (XRD) patterns of the PSINT ceramics indicate that the PSINT sample transforms from the tetragonal (pseudo-cubic) to an R-3C rhombohedral phase. The measurements of the electrocaloric effect revealed a significant adiabatic temperature change (Delta T) of approximately 1.98 K at 60 kV cm(-1) and room temperature with a quenching time of 40 h. This value is 0.5 K higher than that of untreated PSINT ceramics. Moreover, the B-site atoms of the PSINT high-polar-entropy ceramics changed from a long-range ordered phase to a disordered phase after quenching. This study provides a new technical approach for room-temperature cooling devices by designing B-site disorder in relaxor ferroelectric ceramics.

The preparation of high-capacity and fast-charging materials that can provide efficient Li+ storage sites remains a key challenge for room-temperature lithium-ion batteries (LIBs). The volume expansion of the electrode resulting from cycling is also a safety concern for LIBs. For the first time, a Dawson-like MoIV-polyoxometalate (POMoIV) [SbIII 3 MoIV 3 MoVI 15O55(OH)2py3]center dot NH2(CH3)2 center dot 4NH(CH3)2 center dot 2H2O (Sb3Mo18) is applied as LIBs anode material with 36-electron transfer that achieves outstanding reversible capacity of 1070 mA h g-1 (1 A g-1) after 300 cycles, along with high cycle stability and excellent rate performance. The high-performance LIBs can be attributed to the high structure stability of Sb3Mo18 cluster and reversibility of molybdenum valence during rapid charge-discharge cycling. Moreover, the Sb3Mo18 electrode exhibits a low expansion rate of 6.4 % after 100 cycles. The charge-discharge process of the mixed-valence POMoIV in LIBs anodes is performed with X-ray photoelectron spectroscopy test and confirms that POMoIV-based Sb3Mo18 clusters behave active redox properties via a 36-electron transfer. This work demonstrates that Sb3Mo18 with deeply reduced units is a promising high-performance anode material for LIBs and provides a new solution for the rational design of advanced electrode materials.

Deeply reduced polyoxometalates (POMs) capped by early transition metals, [V3IVMo6IVMo4VIO31py6]2- (1, py = pyridine) and [V2IVMo12IVMo8VIZn0.35H1.3+O54py12(HNMe2)2]2- (2), were prepared from solvothermal oxidative aggregations of [Mo3IVO2(O2CCH3)6(H2O)3]ZnCl4 and VO(acac)2 (acac = acetylacetonato). V3-capped Mo6IV-1 and V-capped Mo6IV-2 exhibit 12e-reduced POM structures characteristic of two [Mo3IVO4] incomplete cuboidal cluster units bridged by two(one) VO5 groups in 1(2), differing from those linked by SbO3/GeO4/SbO3-pyZnO4 groups in the previously reported [Sb2Mo6IVMo2VMo4VIO32(OH)2py6]2- (3), [Ge2Mo6IVMo2VMo4VIO34(OH)2py6]4- (4), and [Sb2ZnMo6IVMo2VMo4VIO32(OH)2py7] (5), respectively. Multiple MoIV···O//SbIII Lewis pairs in 1-3 construct well-organized Lewis catalysis fields (LCFs) featuring extensive Lewis acid-base synergistic interactions, which account for their excellent catalytic performance in heterogeneous hydrogen-transfer hydrogenation (HTH) reduction of nitrobenzene to aniline under mild conditions.

A high-performance composite anode material, Sb3Mo18-rGO, was prepared through a hydrothermal reaction of the deeply reduced Dawson-type POM (POMo3IV) [(Sb3Mo3Mo15O55)-Mo-III-Mo-IV-O-VI(OH)(2)py(3)]center dot NH2(CH3)(2)center dot 4NH(CH3)(2)center dot 2H(2)O(Sb3Mo18) and graphene oxide (GO). By synergistically combining the highly reversible 36-electron redox activity of Sb3Mo18 with the conductive graphene network, the Sb3Mo18-rGO anodes exhibited excellent reversible capacity (1220 mA h g(-1) after 250 cycles at 0.5 A g(-1)), outstanding rate performance (835 mA h g(-1) at 2 A g(-1)), and admirable long-term cyclic stability (1002 mA h g(-1) after 600 cycles at 1 A g(-1)) representing the outstanding Li storage/release performance thus far reported for POM-rGO anode materials and providing a new way of thinking for the design of new-generation electrode materials for Li-ion batteries (LIBs).

Given the inherent potential of seawater, industrial wastewater, and residential water as inherent feedstocks for hydrogen production through water electrolysis, there is a critical demand for the exploration of robust and stable hydrogen-evolving catalysts that can operate effectively across a diverse range of pH conditions. However, the pursuit of hydrogen-evolving electrocatalysts that demonstrate both good stability and high efficiency over a wide pH range remains a formidable challenge. Here we report the rational design and synthesis of an outstanding nanoporous hybrid electrocatalyst consisting of intermetallic cobalt-molybdenum alloy particles anchoring on MoO2 cuboid arrays, which demands very low overpotentials of 72, 123 and 134 mV to deliver a current density of −100 mA·cm−2 for hydrogen evolution reaction under alkaline, neutral and acidic conditions, respectively. These catalytic activities are superior to most non-precious-metal-based catalysts documented in the literatures, and are even comparable to noble metal catalysts. In particular, this alloy electrocatalyst exhibits excellent stability at 50 or 300 mA·cm−2 without obvious activity degradation, which is further supported by the undetectable changes in the surface chemical valence states on the basis of in-situ X-ray photoelectron spectroscopic studies. This study provides an innovative strategy for the design and synthesis of effective non-noble intermetallic catalysts for pH-universal hydrogen evolution over a wide pH range.

Recently, electret-based triboelectric nanogenerator (E-TENG) showssignificant advantages for energy harvesting applications, including a largeelectric current and high output stability. Inthis investigation, porous biocompatible polylactide (PLA) film is prepared for E-TENG applications. They found that thesurface potential of the porous PLA-based bioelectret film is maintained at2.1 kV after 86 days of decay,. The measurement data from theE-TENG-based cantilever beam showed that the E-TENG reached an open-circuitvoltage (Voc) of 184 V and a short circuit current (Isc)of 22.4 mu Aat 13.8 Hz. Furthermore, the E-TENG and the PVDF-based piezoelectric nanogenerator (PENG) are combined to create a hybridNG for energy harvesting applications. The data indicate that the maximumoutput power of the hybrid NG reached 73.5 mu Wat 6 M omega,which is 30.7% and 1.91-fold higher than that of the PENG and the E-TENG,respectively. The hybrid NG is used as a powersource to drive a wireless temperaturetransmission system, which can receive a temperature transmission signal from 20 m away. The advantages of biocompatibility,softness and ease of processing make the porous PLA film a great candidate forwearable devices applications. This work presents biocompatible porous polylactide (PLA) film for electret-based triboelectric nanogenerator (E-TENG) application. To increase the output of the device, the E-TENG and the poly(vinylidene fluoride)-based piezoelectric nanogenerator (PENG) are combined to create a hybrid nanogenerator (NG) for energy harvesting applications. The data indicate that the maximum output power of the hybrid NG can reach 73.5 mu W at 6 M omega, which is 30.7% and 1.91-fold higher than that of the PENG and the E-TENG. The hybrid NG is used as a power source to drive a wireless temperature transmission system, which can receive a temperature transmission signal from 20 m away.image

Transoral vestibular robotic thyroidectomy can really make the patient’s body surface free of scar. This study aimed to compare the surgical and patient-related outcomes between the transoral vestibular robotic thyroidectomy and traditional low-collar incision thyroidectomy. The clinical data of 120 patients underwent transoral vestibular robotic thyroidectomy (TOVRT) or traditional low-collar incision thyroidectomy (TLCIT) were collected from May 2020 to October 2021. Propensity score matching analysis was used to minimize selection bias. All these patients were diagnosed with papillary thyroid carcinoma (PTC) through ultrasound-guided fine-needle aspiration prior to surgical intervention and surgical plan was tailored for each patient. An intraoperative recurrent laryngeal nerve (RLN) detection system was used in all patients, whose RLNs were identified and protected. We performed transoral vestibular robotic thyroidectomy with three intraoral incisions. Additional right axillary fold incisions were adopted occasionally to enhance fine reverse traction of tissue for radical tumor dissection. Clinical data including gender, age, tumor size, BMI, operation time, postoperative drainage volume and time, pain score, postoperative length of stay (LOS),number of lymph nodes removed, complications, and medical expense were observed and analyzed. Propensity score matching was used for 1:1 matching between the TOVRT group and the TLCIT group. All these patients accepted total thyroidectomy(or lobectomy) plus central lymph node dissection and all suffered from PTC confirmed by postoperative pathology. No conversion to open surgery happened in TOVRT group. The operative time of TOVRT group was longer than that of TLCIT group (P < 0.05). The postoperative drainage volume of TOVRT group was more than that of TLCIT group (P < 0.05). The drainage tube placement time of TOVRT group were longer than that of TLCIT group (P < 0.05). Significant differences were also found in intraoperative bleeding volume, pain score and medical expense between the two groups (P < 0.05). The incidence of perioperative common complications such as hypoparathyroidism and vocal cord paralysis in the two groups was almost identical (P > 0.05). However, there were some specific complications such as surgical area infection (one case), skin burn (one case), oral tear (two cases), and paresthesia of the lower lip and the chin (two cases) were found in TOVRT group. Obviously, the postoperative cosmetic effect of the TOVRT group was better than TLCIT group (P < 0.05). TOVRT is safe and feasible for low to moderate-risk PTC patients and is a potential alternative for patients who require no scar on their neck. Patients accepted TOVRT can get more satisfaction and have less psychologic injury caused by surgery.

Recently, the combination of the piezoelectric effect in the photocatalytic process, referred to as piezo-photocatalysis, has gained considerable attention as a promising approach for enhancing the degradation of organic pollutants. In this investigation, we studied the piezo-photocatalysis by fabricating arrays of barium strontium titanate (Ba0.7Sr0.3TiO3) nanorods (BST NRs) on a glass substrate as recoverable catalysts. We found that the degradation rate constant k of the rhodamine B solution achieved 0.0447 min(-1) using poled BST NRs in the piezo-photocatalytic process, indicating a 2-fold increase in efficiency compared to the photocatalytic process (0.00183 min(-1)) utilizing the same material. This is mainly ascribed to the generation of the piezopotential in the poled BST NRs under ultrasonic vibration. Moreover, the BST NR array demonstrated a hydrogen (H-2) production rate of 411.5 mu mol g(-1) h(-1). In the photoelectrochemical process, the photocurrent density of poled BST NRs achieved 1.97 mA cm(-2) at an applied potential of 1.23 V (E-RHE (reversible hydrogen electrode)) under ultrasonic vibrations, representing a 1.7-fold increase compared with the poled BST NRs without ultrasonic vibrations. The measurement results from the liquid chromatograph mass spectrometer (LC-MS) demonstrated the formulation of a degradation pathway for rhodamine B molecules. Moreover, ab initio molecular dynamics (AIMD) simulation results demonstrate the dominance of hydroxyl radicals ((OH)-O-center dot) rather than superoxide radicals (O-center dot(2)-) in the degradation process. This study not only benefits the understanding of the principle of the piezo-photocatalytic process but also provides a new perspective for improving the catalytic efficiency for organic pollutants degradation.

The development of miniature devices has generated a large demand for dielectric polymers with high energy storage density, especially at high temperatures. First, poly(methyl methacrylate) (PMMA)-coated nanodiamond (ND) particles were incorporated into a polyimide (PI) substrate to fabricate ND-g-PMMA/PI (NPP) composites. We found for the first time that with a very low content (0.4 vol.

14e-reduced hollow MoIV6-ε-Keggin POMs exhibit highly enhanced electrical conductivity and maintain their structural integrity during 24e-redox processes compared to fully oxidized POMs.

Poly( l ‐lactic acid) (PLLA) films have excellent piezoelectric properties, but the strong hydrophobicity of the surface makes it difficult for cells to attach there. PLLA nanofibers have good biocompatibility, but the weak piezoelectric coefficient limits the ability of the nanofibers to stimulate cell growth. Therefore, the PLLA piezoelectric film is combined with the PLLA nanofibers to make a multilayer film. In our tests, the piezoelectric output of the multilayer film ≈260 mV. In the biological experiments section, without piezoelectric stimulation, the cell length on the nanofibers is approximately twice that of the cells in the blank control group. The length of cells cultured on piezoelectric‐based stimulated nanofibers is more than twice that of cells cultured on nanofibers without piezoelectric stimulation. Therefore, it is confirmed that under the dual action of nanofiber guidance and piezoelectric stimulation, the growth rate of cells is four times faster than that in ordinary Petri dishes. Intracellular calcium imaging experiments confirmed that the concentration of Ca 2+ in electrically stimulated cells is approximately twice that of ordinary cells. It is also confirmed that piezoelectric materials can complete electrical stimulation of cells in indirect contact with cells.

BNT-6BT-based lead-free ceramics have gained significant attention due to their relatively large piezoelectric coefficients and tunable morphotropic phase boundary conditions. In this investigation, SrTiO3 (ST) was added to BNT-6BT ceramics to fabricate the BNT-6BT-xST (BNBT-xST) composition. The impact of ST content on the phase structure and dielectric permittivity of the BNBT-xST ceramics was studied. The XRD refinement data show that with increasing ST content, the crystal structure of BNBT-xST ceramics was transformed from the morphotropic phase structure (coexisting tetragonal (P4/mmm) and pseudo-cubic (Pmm) phase) to the pseudo-cubic phase. The dielectric permittivity data of the BNBT-80ST showed that the Tm (the maximum permittivity temperature) moved to-61.9 degrees C, which caused the room temperature to fall within the range of Tm < T < TB (the Burns temperature). This makes the BNBT-80ST a superparaelectric state in relaxor ferroelectrics (RFE). Furthermore, the maximum energy density and the charge-discharge efficiency of the BNBT-80ST achieved 5.48 J/cm3 and 87% at 495 kV/cm, respectively. The energy density of the BNBT-80ST was improved by 2.97-fold and 49% compared with that of the BNBT-30ST and BNBT-70ST. This is mostly attributed to weakened ferroelectricity and improved paraelectricity in the BNBT-80ST. This investigation demonstrates that BNBT-xST ceramics can be adjusted to a superparaelectric state with an ST content of 80%. This makes the material to possess both a large polarization and a high breakdown field. This material holds great promise for high energy density capacitor applications.

In this work, we successfully prepared vertically aligned NaNbO 3 nanotube (NN-NT) with trapezoidal shapes, in which the orthorhombic and monoclinic phases coexisted. According to the structure analysis, the NN-NT/epoxy composite film had excellent flexoelectric properties due to the lattice distortion caused by defects and irregular shape. The flexoelectric effect is the greatest in the vertical direction in the flexible NN-NT/epoxy composite film, and the flexoelectric coefficient ( μ _12^' ) is 2.77 × 10 −8 C·m −1 , which is approximately 5-fold higher than that of the pure epoxy film. The photovoltaic current of the NN-NT/epoxy composite film increased from 39.9 to 71.8 nA·cm −2 in the direction of spontaneous polarization when the sample was bent upward due to the flexoelectricity-enhanced photovoltaic (FPV) effect. The flexoelectric effect of the NN-NT/epoxy composite film could modulate the photovoltaic response by increasing it by 80

Electrochemical hydrogen production from water splitting is one of the effective methods for hydrogen production that has recently attracted particular attention. One of the limitations of the electrochemical water splitting method is the slow oxygen evolution reaction (OER), which leads to an increase in overpotential and a decrease in hydrogen production efficiency. Here, Ni-Mo-S ultra-thin nanosheets were synthesized using the pulse reverse electrochemical deposition technique, and then this electrode was used as an electrode material for accelerating hydrogen evolution reaction (HER) and urea oxidation reaction (UOR). Remarkably, the optimized electrode needs only 74 mV to attain the 10 mA cm-2 current density in HER and require only 1.3 V vs RHE potential in the UOR process. Also, results showed that the replacement of the UOR with the OER process resulted in a significant improvement in the electrochemical production of hydrogen in which for delivering the current density of 10 mA cm-2 in overall urea electrolysis, only 1.384 V is needed. In addition, outstanding catalytic stability was obtained, after 50 h electrolysis, the voltage variation was negligible. Such outstanding catalytic activity and stability was due to 3-D ultrathin nanosheets, the synergistic effect between elements, and the superhydrophilic/ superaerophobic nature of fabricated electrode. & COPY; 2023 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.

The development of an efficient and environment-friendly photocatalyst for antibiotics degradation is of great significance and still remains a major challenge. Herein, a novel Sillén-Aurivillius layered oxide Bi7Fe2Ti2O17Cl is successfully synthesized via a one-step flux route (noted as F-BFTOC) and solid-state reaction (noted as S-BFTOC). The as-prepared F-BFTOC manifests the enhanced visible-light photocatalytic performance towards tetracycline (TC) degradation compared with Bi4NbO8Cl and its degradation efficiency reaches 90% within 90 min. Additionally, the proposed degradation pathway and photocatalytic mechanism are systematically investigated by liquid chromatography tandem-mass spectrometry (HPLC-MS), active species trapping test, electron spin resonance (ESR) and first-principles calculations. The superior degradation of antibiotics is primarily derived from the photo-generated h+, and radical ·O2− as the dominant active species. More importantly, the F-BFTOC exhibits excellent cycle stability and TC is ultimately transformed into non-toxic open-loop products. Simultaneously, Rhodamine B (RhB) as a typical organic pollutant is further employed to evaluate the photocatalytic activity of F-BFTOC, and 98% of the degradation efficiency is achieved. BFTOC as a multifunctional photocatalyst for pollutant degradation offers a new insight for Sillén-Aurivillius photocatalytic in the field of water purification.

背景与目的:纳米炭作为新型淋巴结示踪剂,已广泛应用于传统的甲状腺癌根治术中.目前,微创手术是时代的主题,机器人的应用使得微创手术获得更好的发展,其安全性、有效性得到广泛认证.因此,本研究探讨在机器人甲状腺癌根治术中应用纳米炭示踪剂对淋巴结清扫的效果,以期为临床应用提供参考.方法:回顾性分析294例行达芬奇机器人甲状腺乳头状癌根治术患者资料,其中160例术中使用纳米炭示踪剂(研究组),134例未使用纳米炭(对照组).比较两组术后中央区及颈侧区淋巴结清扫总数、阳性淋巴结数目、淋巴结清扫手术时间及颈侧区淋巴结清扫并发症发生率.结果:两组间年龄、性别、肿瘤大小、TNM分期、浸润被膜与否方面差异均无统计学意义(均P＞0.05).研究组平均中央区的淋巴结检出数(13.46枚vs.8.66枚)及其平均阳性淋巴结检出数(3.38枚vs.2.31枚)均明显高于对照组(均P＜0.05);研究组平均颈侧区淋巴结检出数高于对照组(15.21枚vs.1.44枚,P＜0.05),但其平均阳性淋巴结检出数与对照组差异无统计学意义(P＞0.05).研究组行平均单侧中央区淋巴结清扫时间(77.08 min vs.88.83 min)、双侧中央区清扫时间(128.29 min vs.160.11 min)、中央区+颈侧区清扫时间(199.93 min vs.221.64 min)均明显少于对照组(均P＜0.05),两组各项颈侧区淋巴结清扫术后并发症发生率差异均无统计学意义(均P＞0.05).结论:机器人甲状腺癌手术应用纳米炭可显著增加检获淋巴结的数量,提高中央区淋巴结的检出阳性率,并可以缩短淋巴结清扫时间.

Alkaline water electrolysis is an advanced technology for scalable H-2 production using surplus electricity from intermittent energy sources, but it remains challenging for non-noble electrocatalysts to split water into hydrogen and oxygen efficiently, especially for tungsten disulfide (WS2)-based catalysts. Density functional theory calculations in combination with experimental study are used to establish a multi-site engineering strategy for developing robust WS2-based hybrid electrocatalyst on mesoporous bimetallic nitride (Ni3FeN) nanoarrays for bifunctional water splitting. This ingenious design endows the catalyst with numerous edge sites chemically bonded with the conductive scaffold, which are favorable for water dissociation and hydrogen adsorption. Benefiting from the synergistic advantages, the N-WS2/Ni3FeN hybrid exhibits exceptional bifunctional properties for hydrogen and oxygen evolution reactions (HER and OER) in base with excellent large-current durability, requiring 84 mV to afford 10 mA cm(-2) for HER, and 240 mV at 100 mA cm(-2) for OER, respectively. Assembling the catalytic materials as both the anode and cathode to construct an electrolyzer, it is actualized very good activities for overall water splitting with only 1.5 V to deliver 10 mA cm(-2), outperforming the IrO2(+)//Pt(-) coupled electrodes and many non-noble bifunctional electrocatalysts thus far. This work provides a promising avenue for designing WS2-based heterogeneous electrocatalysts for water electrolysis.

Objective To compare the surgical outcomes between the transoral-vestibular robotic thyroidectomy (TOVRT) and bilateral axillo-breast approach robotic thyroidectomy (BABART). Methods A total of 99 patients with papillary thyroid carcinoma but no distant metastasis were enrolled in this study from May 2020 to April 2021. Lobectomy or total thyroidectomy with central lymph node dissection were performed in all cases. All 99 patients were received an ultrasound guided fine needle aspiration biopsy prior to surgical intervention, out of which 49 patients underwent TOVRT, while rest 50 patients underwent BABART. During the procedure, intraoperative neuromonitoring system was used and all recurrent laryngeal nerves (RLNs) were preserved, additionally for TOVRT procedure, three intraoral ports or right axillary fold incision was used to allow for fine countertraction of tissue for radical oncological dissection. The clinical data including age, gender, height, weight, BMI, primary tumor size, number of central lymph node removed, central lymph node metastasis, operating time, total hospital stays, postoperative hospital stays, total postoperative drainage volume, postoperative pain score, cosmetic effect and complications were recorded and analyzed. Results There were no significant differences in gender, height, weight, BMI and removed central lymph nodes between the two groups ( P > 0.05). Patients accepted TOVRT were younger and had smaller primary tumor size than those who accepted BABART. The TOVRT group had a longer surgical time than the BABART group, but with smaller postoperative drainage volume and superior cosmetic effect (under visual analogue scale, VAS) ( P < 0.05). There was no significant difference in lymph node metastasis, hospital stay and postoperative pain score (under numerical rating scale, NRS) between the two groups ( P > 0.05). Last but not least, certain peculiar complications were observed in TOVRT group: paresthesia of the lower lip and the chin (one case), surgical site infection (one case) and skin burn (one case). Conclusion Transoral-vestibular robotic thyroidectomy is safe and feasible for certain patients, which could be considered an alternative approach for patients who require no scarring on their neck.

目的 分析甲状腺癌手术后难治性乳糜漏的临床特点，探讨难治性乳糜漏的治疗策略。方法 回顾性分析解放军第九六〇医院（原济南军区总医院）2009年1月至2021年1月期间收治的5 021例行甲状腺癌颈淋巴结清扫术患者的临床资料，术后发生乳糜漏122例，其中治疗时间超过2周的难治性乳糜漏34例，对难治性乳糜漏患者的一般情况、治疗方式、峰值引流量（日最高引流量）、带管时间等进行分析总结。结果 5 021例患者中发生乳糜漏122例，占所有患者的2.4%。经非手术治疗2周内治愈者88例，占乳糜漏总数的72.1%；治疗时间超过2周的难治性乳糜漏34例，占乳糜漏总数的27.9%。难治性乳糜漏经非手术方法治愈者18例，经再次手术治愈者16例，2组患者的乳糜漏位置左侧多于右侧；34例难治性乳糜漏峰值引流量（日最高引流量）手术组（16例）高于非手术组（P＜0.05），带管时间手术组短于非手术组（P＜0.05）。结论 低峰值引流量乳糜漏经非手术治疗多可治愈；难治性乳糜漏左侧多见，高流量乳糜漏（峰值引流量≥1 000 mL）宜早期实施手术治疗。