OBJECTIVE:To explore the toxic effect on mouse administrated Kudiezi injection multy times a day, and on rats repeat administrated for many days.METHOD:Mouse tail intravenous injection of Kudiezi, 0.04 mL x g(-1), 3 times a day, rats tail intravenous injection of Kudiezi, 20, 10, 4 mL x kg(-1), once a day, for 6 weeks.RESULT:There is no abnormal to the mouses administrated many times a day. The rats administrated large doses of drug for many days have certain effects on hematology, blood biochemistry. Some animals appear liver, kidney lesions mild, injection local appear haemorrhage, edema and inflammatory reaction.CONCLUSION:The mouse which was intravenous injection in the dose of 180 times Kudiezi injection as much as people used, revealed no toxicity reaction. Repeated large-dose administration, rats caused by lesions of the main target organs may be for kidney, liver. But the recovery result on liver, kidney toxicity was reversible, no delayed toxicity. At the same time, large doses of long-term administration of local have a certain irritation. Tips the medication should be under the guidance of doctors, and pay attention to replace the injection site. This research will provide safety basis for the clinical use of Kudiezi injection.

目的:观察鼻通水的抗炎作用.方法:观察鼻通水及对照药鼻通丸对小鼠耳肿胀及大鼠腹部毛细血管通透性的作用.并以二甲苯小鼠鼻腔滴注制作鼻炎模型,观察鼻通水及对照药的治疗作用.结果:鼻通水具有较好的抗炎作用,并呈一定的量效关系,并对二甲苯致小鼠鼻部炎症有良好的防治作用.结论:鼻通水是防治鼻炎的有效药物.