Objective To investigate the status of anxiety of the clinical Emergency Department nurses.Methods A total of 78 subjects who are the clinical Emergency Department nurses accepted the questionnaire survey. The status of anxiety was measured by Self-Rating Anxiety Scale(SAS, Zung ,1971), it analyzed with the Chinese norm controls.Results The rate of anxiety status among nurses in this study was 19.2%. SAS score of nurses in Emergency Department was higher than that of Chinese norm controls.Conclusion The anxiety status of nurses in Emergency Department were more common. The mental state of nurses in the clinical Emergency Department should be attention and provide proper intervention.

目的：探讨根据中国精神障碍分类与诊断标准第3版（CCMD-3）诊断的老年型、老年前期型和混合型阿尔茨海默病（AD）患者间血脂、胰岛素代谢、对氧磷酶-2（PON2）311基因多态性的差异和特点。方法研究对象包括84例AD患者，符合美国国立神经病学、语言障碍和卒中研究所-AD和相关疾病协会（ NINCDS-ADRDA）“可能AD”的诊断标准，无痴呆家族史。根据CCMD-3分为老年型、老年前期型和混合型三组，用聚合酶链反应-限制性片段长度多态性分析法检测患者PON2基因311位点多态性，检测血清胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、空腹血糖（FBP）。利用化学发光法测空腹血清胰岛素。利用基础状态法评定胰岛素抵抗性，临床上可使用胰岛素敏感指数（ISI）表达。应用简明智能评定量表（MMSE）、日常生活能力量表（ADL）、Hachinski缺血量表等评定三组患者的认知等临床特征。分析三组间PON2 C311S基因多态性、血清胰岛素、血糖、血脂和神经心理学量表得分的差异。结果老年前期型 AD组的血清 TG和 TC 高于老年型和混合型 AD组（ P＜0.01）。老年型AD组的HDL水平高于混合型AD组（P＜0.01）。老年前期型AD组的血清胰岛素水平高于老年型和混合型AD组（P＜0.01）。老年型、老年前期型和混合型AD三组间的PON2311基因型C/C、C/S和S/S分布差异无统计学意义，3组间C和S等位基因频率也无统计学差异。结论老年前期型AD 患者应加强血脂和胰岛素代谢的重视和干预。不同亚型的AD患者PON2基因311位点基因型及等位基因频率未发现显著差异。

Objective To examine the association among behavioural and psychological symptoms of Alzheimer's disease and insulin resistance,metabolic syndrome(MS).Methods This study included 86 patients with Alzheimer's disease who were divided as two groups according to the diagnostic criteria of metabolic syndrome by Chinese Medical Association Diabetes Branch.That was Non-MS(NMS)group and MS group.All subjects did not have family history of dementia and had fasting levels of glucose,insulin,lipid and blood pressure measured.Insulin resistance was estimated with the Insulin Sensitive Index(ISI).Behavioural and psychological symptoms of AD was assessed by Neuropsychiatric Inventory(NPI).Results The very seldom symptom of both group was elation/euphoria.The most common symptom of MS group was irritability(92.3%)and that of NMS group was aberrant motor behavior(78.5%).There were obviously more symptoms of agitation and irritability in MS group than that in NMS group(P<0.15).Age,systolic blood pressure and low density lipoprotein were associated with NPI score(P<0.15).Fasting insulin and ISI had not obviously difference between two groups.Conclusions Our finding suggest MS influence behavioural and psychological symptoms of Alzheimer's disease.What's more,the finding suggest insulin resistance is not associated with NPI score.

Objective To investigate the change of peripheral insulin resistance,serum insulin,cholesterol,triglyceride and cortisol in sporadic Alzheimer's disease(SAD). Methods To measure serum concentration of insulin,cholesterol,triglyceride cortisol and fasting serum glucose in 34 patients with SAD and 32 normal controls respectively,calculate insulin sensitive index (ISI). After grouping by degree of dementia with Clinical Dementia Rating Scale,the results were compared between each two groups. Results The levels of serum insulin,cortisol and ISI had no significant difference among each groups (P>0.05). Serum total cholesterol and triglyceride levels in mild AD patients were significant higher than those in moderate and severe AD patients (P<0.05),triglyceride in moderate AD and cholesterol in severe AD patients were significant lower than those in normal elder (P<0.05). Conclusion Peripheral insulin resistence in some patients with SAD perhaps had no significant change,the level of serum cholesterol and triglyceride decreased with worsening of degree,These results suggest that we should pay more attention to nutrition support on moderate and severe AD patients.