Secondary injury factors could cause nerve cell apoptotic after traumatic brain injury,cell apoptotic is important reason which contributes to brain cell death.Relevant research of gene to solve cell apoptotic is ultimately mechanism,this process is regulated by bcl-2,caspase,p53,immediate early genes and others genes.Apoptotic have important function on the prognosis of traumatic brain injury.Through initiative intervention gene regulation and depress nerve cell apoptotic,thus reach the protective function of the brain.