目的 探讨普通球囊(POB)与药物涂层球囊(DCB)在下肢动脉硬化闭塞症(ASO)患者介入手术中的应用效果.方法 选取2019年1月至2021年5月内蒙古自治区人民医院收治的100例下肢ASO患者为研究对象.根据计算机随机化法将患者分为试验组(采取DCB扩张治疗)和对照组(采取POB扩张治疗),每组50例.比较两组患者术前、术后3个月的临床指标[下肢动脉狭窄程度、下肢动脉最小管腔直径(MLD)、踝肱指数(ABI)],术后当天、术后3个月的晚期管径丢失量,Rutherford分级情况,术后并发症及不良事件发生情况.结果 术后3个月,试验组患者的下肢动脉狭窄程度、晚期管径丢失量均低于对照组患者,ABI、下肢动脉MLD均高于对照组患者,差异均有统计学意义(P<0.05).试验组Rutherford分级≤3级的患者比例高于对照组患者,术后并发症、不良事件的总发生率均低于对照组患者,差异均有统计学意义(P<0.05).结论 POB与DCB在下肢ASO患者介入手术中均具有一定的治疗效果,其中,DCB扩张治疗可更好地改善下肢ASO患者的病情,降低患者的Rutherford分级、术后并发症及不良事件总发生率.

目的:探究脱细胞真皮基质治疗对糖尿病足综合征合并下肢动脉硬化闭塞患者神经病变的缓解作用和对足部功能的影响.方法:选择本院2017.5-2020.5收治的80例糖尿病足综合征合并下肢动脉硬化闭塞患者平均分为观察组和对照组2组,其中对照组患者给与常规干预结合下肢动脉腔内治疗,观察组则在对照组的基础上实施脱细胞真皮基质治疗.分析两组患者治疗前后TCSS评分、神经传导速度、足部功能、治疗效果、创面感染发生率、治疗费用以及并发症发生率的差异.结果:治疗后观察组患者TCSS评分和足部功能评分均较对照组低,神经传导速度较对照组快,差异有统计学意义(P＜0.05);观察组患者治疗总有效率、患者创面感染发生率和并发症发生率分别为100.00％、2.50％和2.50％,对照组患者则分别为80.00％、17.50％和55.00％,且对照组住院费用较观察组高,差异有统计学意义(P＜0.05).结论:脱细胞真皮基质治疗对糖尿病足综合征合并下肢动脉硬化闭塞患者神经病变具有确切的缓解作用,尤其对足部功能效果显著,值得临床广泛推广使用.

目的:为提高治疗效率,本研究对髂静脉压迫综合征合并下肢深静脉血栓患者的导管接触溶栓同期球囊扩张+支架治疗方案和分期治疗方案进行比较.方法:以65例髂静脉压迫综合征合并下肢深静脉血栓患者为研究对象,根据治疗方法分为研究组和对照组,研究组32例,进行导管接触溶栓同期球囊扩张+支架治疗,对照组33例,进行导管接触溶栓分期球囊扩张+支架治疗.以治疗前后患者大腿围、小腿围、血管通畅评分,手术指标(住院时间、住院次数、溶栓时间及穿刺次数),并发症(血栓复发、出血以及肺栓塞)及深静脉血栓后遗症为指标,考察两组疗效.结果:两组患者大腿围、小腿围和静脉畅通评分在治疗前均无显著差异(P＞0.05),经过治疗,两组大腿围、小腿围和静脉畅通评分均显著改善(P＜0.05),但两组间各项指标无显著差异(P＞0.05).研究组患者住院时间、住院次数、溶栓时间及穿刺次数均显著低于对照组(P＜0.05).研究组血栓复发0例,对照组血栓复发4例,有显著差异(P＜0.05);研究组出血1例,肺栓塞0例,对照组出血2例,肺栓塞0例,两组出血和肺栓塞情况比较,无显著差异(P＞0.05).研究组PTS发生率为6.25％,显著低于对照组的18.18 ％(P＜0.05).结论:导管接触溶栓同期球囊扩张+支架治疗方案对髂静脉压迫综合征合并下肢深静脉血栓有良好的疗效.

目的观察下肢静脉性溃疡患者穿静脉功能不全情况，探讨静脉造影定位下肢穿静脉结扎对下肢静脉性溃疡术后疗效的影响。方法40例大隐静脉曲张患者随机分成两组：A组采用大隐静脉高位结扎、静脉腔内激光闭合术及术前下肢静脉造影定位穿静脉术中结，B组采用大隐静脉高位结扎和静脉腔内激光闭合术治疗。观察两组患者治疗后静脉性溃疡的愈合时间。结果术后两组愈合时间分别是（7.4±3.327）w和（11.4±5.388）w，两组比较差异具有统计学意义（=0.047）。结论下肢静脉造影可有效检测定位瓣膜功能不全的下肢穿静脉，行大隐静脉高位结扎、静脉腔内激光闭合术联合穿静脉结扎治疗下肢静脉性溃疡的疗效优于穿静脉不结扎。

Objective To explore the effect of high ligation combined with endovenous laser in the treatment of great saphenous varicose veins. Methods 90 patients with great saphenous varicose veins admitted in our hospital during August 2012 and August 2014 were randomized into observation group(n=45) and control group(n=45) in which high ligation combined with endovenous laser and single endovenous laser were performed in them respectively. The therapeutic effects of the two groups were compared. Results After treatment, the unilateral operation time, incision number, intraoperative blood loss and hospitalization time of the two groups were(44±9)min,(3±1),(20±9)mL;(4±2)d vs(79±9)min,(5±2),(59±19)mL,(11±3)d, therefore in terms of clinical in-dicators above, the observation group was superior to the control group with statistically significant difference(P<0.05). What's more, there was statistically significant difference in complication rate between the two groups, 35.48%vs 59.68%(P<0.01). Conclusion High ligation combined with endovenous laser is worthy of clinical promotion in the treatment of great saphenous varicose veins due to its remarkable effect and low complication rate.

[Objective] To compare the efficacies of surgery versus interventions for diabetic mellitus with lower limb ischemic .[Methods] A total of 113 patients of diabetic mellitus with lower limb ischemic were di‐vided into four groups of TASCⅡC surgery ( n =30) ,TASCⅡD surgery ( n =27) ,TASCⅡC intervention ( n=29) and TASCⅡD intervention ( n=27) .The surgery was femoro‐popliteal artery bypass grafting while intervention stenting .For four groups ,the parameters of patency rate ,ankle‐brachial index (ABI) ,rates of survival ,limb salvage and complications were recorded at 1 week ,3 months ,6 months and 1 year .[Results]After 1 week and 3 months ,surgery and intervention groups showed no significant difference in patency rate or ABI ( P >0 .05) .At 6 months and 1 year ,patency rate and ABI were higher in surgery group than those in intervention group ( P<0 .05) .Among 4 groups ,the rates of limb salvage and survival showed no statistical‐ly significant differences ( P>0 .05) .And complication rate was lower in surgery group than that in interven‐tion group ( P < 0 .05) .[Conclusion] Surgery and interventional stenting have similar rates of limb salvage and survival .However ,surgery offers better long‐term efficacies .

目的：探讨负压封闭引流装置在行下肢大动脉搭桥合并感染患者治疗的应用价值。方法对8例下肢动脉搭桥术后出现切口感染患者进行治疗，术后感染创面使用VSD装置，观察引流及拆除VSD装置后患者的全身及伤口局部情况。结果8例患者在引流过程中伤口无需频繁换药，局部红肿逐渐消退，无全身发热等感染中毒症状或症状迅速得到改善，拆除VSD装置后创面较干净，渗出物少，肉芽组织新鲜"经术后1~2个月随访，伤口愈合好，无切口二次感染复发。结论下肢动脉搭桥术后感染患者，术后使用VSD装置，能引流彻底并很好地控制感染并促进肉芽组织生长，减少换药次数。

Objective: To investigate the hospital with chronic lymphocytic thyroiditis (CLT) combined incidence of thyroid cancer and the clinical diagnosis of thyroid cancer CLT merger, treatment and prognosis.Methods:A retrospective analysis of clinical data of our department from October 2011 to September 2013 during the three cases CLT with thyroid cancer.Results:The incidence of thyroid cancer in the combined group CLT was 2.4% (3/125). Preoperative diagnostic accuracy was 27.88%. Ultrasonic Tip patients with thyroid nodules and calcification. This group of patients underwent surgery with good results.Con-clusion:CLT could be thyroid cancer precursor lesions. CLT combined for thyroid nodules should consider surgery, especially preoperative ultrasound prompted calcification. For CLT with thyroid cancer thyroid cancer surgery should take the principles of radical surgery for surgery.

Objective To study the great saphenous vein high ligation joint lumen laser for the treatment of closed lower extremity varicose veins clinical effect.Methods Between January 2013 and May 2013 in our hospital between treatment of 68 patients with lower extremity varicose veins, were divided into treatment group and control group, 34 cases, adopt different treatment the curative effect comparison.Results Treatment group in 17 cases cured, 3 had no effect, the effective rate was 91.2%; the control group in 9 cases cured, 12 cases ineffective, effective rate was 64.7%. Two sets of results compared with signiifcant difference (P<0.01).Conclusion The great saphenous vein high ligation joint lumen laser closed surgery is an effective in the treatment of varicose veins of lower limb, which were liable to occur during laser closed operation complications, worthy of clinical research.

Objective To study the clinical effect of interventional therapy for elderly patients with arteriosclerosis obliterans in lower extremity. Methods 60 patients with arteriosclerosis obliterans in lower extremity admitted in our hospital during April 2012 and April 2013 were randomly divided into control group in which the 30 patients were treated with artificial vessels bypass, and the observation group in which the other 30 patients underwent interventional therapy. The total effective rates and recurrence rates were compared between them. Results The total effective rate was higher in the observation group (96.7%) than in the control group (80.0%) with statistically significant difference(P<0.05); 1 year follow-up showed that the recurrence rate was lower in the observation group(3.3%) than in the control group(13.3%) with statistically significant difference(P<0.05). Conclusion Interventional therapy is worthy of clinical application and promotion in the treatment of elderly patients with arteriosclerosis obliterans in lower extremity due to its remarkable effect.

目的 探讨脑梗死患者血清白介素-18水平变化的临床意义.方法 采用ELISA法检测脑梗死患者(CI组)和健康对照组(NC组)的血清IL-18水平,并进行比较.结果 CI组患者血清IL-18水平显著高于NC组(t=9.029,P＜0.05).结论 急性脑梗死患者血清IL-18水平明显升高,因而对于炎症介质的早期干预治疗,可能有助于梗死后神经功能的修复及临床症状的改善.

Secondary injury factors could cause nerve cell apoptotic after traumatic brain injury,cell apoptotic is important reason which contributes to brain cell death.Relevant research of gene to solve cell apoptotic is ultimately mechanism,this process is regulated by bcl-2,caspase,p53,immediate early genes and others genes.Apoptotic have important function on the prognosis of traumatic brain injury.Through initiative intervention gene regulation and depress nerve cell apoptotic,thus reach the protective function of the brain.