Objective To investigate the levels and clinical significance of matrix metalloproteinase-9(MMP-9), cellular fibronectin(c-Fn), matrix metalloproteinase inhibitors-1(TIMP-1), interleukin-6 and Fibrinogen(Fbg) in plas-ma of patients with early hematoma enlargement of cerebral hemorrhage , to provide the basis for screening the predic-tive indexes of early hematoma enlargement.Methods Eighty-six patients with cerebral hemorrhage from February 2010 to November 2012 in the first affiliated hospital of Zhengzhou university were randomly selected as subjects .The enzyme-linked immunosorbent assay ( ELISA) was used to determine the expression of MMP-9, c-Fn and TIMP-1, the electrochemi-cal luminescence was performed to identify IL-6 level, and the solidification(turbidity) method was applied to detect Fbg content in patient plasma .Results Brain CT testing for 78 individuals at the onset of the disease within 24 hours in 86 pa-tients were shown that 19 cases with hematoma enlargement , the incidence was 24.36%, and the incidence of irregular he-matoma in intracerebral hematoma enlargement group ( 47.3%) was obviously higher than that of no-enlarged group (8.5%), the difference was significant(P<0.05).The Fbg level in hematoma enlargement group and no-enlarged group was(2.8 ±0.7)g/L and(2.3 ±0.6)g/L, respectively(P <0.05), and the IL-6 level was(21.6 ±8.1)pg/ml and (14.7 ±5.6)pg/ml(P<0.05).There was no significant difference in MMP-9, c-Fn TIMP-1 between the enlargement group and no-enlarged group(P>0.05).Conclusions Levels of Fbg, IL-6 and MMP-9 have strong correlation with in-tracerebral hematoma enlargement , but the relativity between c-Fn, TIMP-1 and hematoma enlargement is comparatively no obvious.The data provid us the theoretical basis of exploring the early hematoma enlargement in intracerebral hemorrhage .

目的:研究椎间盘射频热凝术中应用艾司洛尔对心肌缺血患者的心肌保护作用。方法:选取(ASA)分级Ⅱ～Ⅲ级,拟行椎间盘射频热凝术的心肌缺血患者30例。完全随机法分为观察组和对照组各15例,入室后均以瑞芬太尼、丙泊酚恒速输注,观察组同时输注艾司洛尔50μg/(kg.min)。分别记录患者术前(T0)、针入安全三角时(T1)、针入椎间盘(T2)、射频温度为95℃时(T3)的心率(HR)、收缩压(SBP)、心率-收缩压乘积(RPP)、心电图ST段变化及心肌缺血发生率。结果:射频治疗期间(T1～T3),观察组HR[(71.2±5.8)次/min、(68.3±3.8)次/min、(68.4±4.8)次/min]明显低于相同时点对照组[(78.1±4.4)次/min、(81.4±9.3)次/min、(87.8±9.3)次/min,均为P<0.05];观察组RPP[(9 149.9±1 450.3)、(9 143.4±1 063.6)、(9 068.1±1 387)]均明显低于对照组[(11 194.1±1 450.1)、(11 866.7±1 920.1)、(12 389.3±2 728.2),均为P<0.05]。观察组心肌缺血发生率(1/15,6.7%)、持续时间121 s均明显小于对照组(6/15,40.0%)、(230.0±13.0)s,均为P<0.05。结论:椎间盘射频热凝术中应用艾司洛尔降低心肌缺血患者术中心肌氧耗及心肌缺血发生率。