OBJECTIVE To investigate the effects of purple sweet potato flavonoids on learning ability and memory in senescent mice induced by D-galactose and study the protective effect on oxidative injury in the brains of aging mice.METHODS ICR mice were randomly divided into 6 groups (n =10):normal control group(NC),model group,vitamin C group (100 mg·kg-1 ·d-1) and PSPF groups (50,100,200 mg·kg-1 ·d-1) ; except NC group,all the other groups were subcutaneously injected with 1 g· kg-1 · d-1 D-galactose for successive 42 days to establish the sub-acute senescent model.All groups were given corresponding drugs respectively by intragastric administration 1 week later.Then the learning and memory ability of mice were measured by Morris water maze test,the amount of MDA in mouse brain tissue and the activities of SOD and GSH-PX were detected.RESULTS Compared with the model group,PSPF (1 00,200 mg· kg-1 · d-1) could significantly improve aging sign,reduce latent period to find the hidden platform and the time of first crossing the non-exits (P＜0.05) and increase the number of crossing non-exits (P＜0.05).PSPF could also effectively improve the activities of SOD and GSH-PX,reduce the amount of MDA (P＜0.05,P＜0.01)with dose-dependent tendency.CONCLUSION PSPF can significantly improve the learning and memory ability of senescent mice induced by D-galactose,has the function of delaying senility.The mechanism may be related to its enhancement of activity of antioxidases,scavenging free radicals and improving the antioxidant ability.

本实验经过腹腔注射CCl4的途径诱导ICR小鼠肝脏的损伤,通过组织形态学、生化指标及免疫组织化学检测来研究抗氧化物质槲皮素对CCl4引起的肝脏氧化损伤的修复作用。性成熟雄性小鼠分成3组:对照组、CCl4模型组（处理剂量为800μl/kg体重,溶于橄榄油中）、口服槲皮素

<正>本实验研究了葡萄籽原花青素提取物(GSPE)对于硫代乙酰胺(TAA)诱导的实验性小鼠肝纤维化的影响。TAA连续给药9周,导致大量的肝实质细胞的坏死和凋亡,当肝细胞的增殖不足以弥补肝细胞的缺失时,就会导致肝星状细胞(HSC)的激活和细胞外基质的大量沉积。此外,活化的HSC的两个标记,即转化生长因子β1(TGF-β1)、平滑肌动蛋白α(α-SMA)的mRNA

It is important to use preparation ways to improve β-carotenes′ bioavailability, and the research and development of four main ways, organic solvent, milling, high temperature high pressure way and supercritical way were reviewed.