[Objective]To evaluate the Shengmai Injection combined with Western medicine treatment of viral myocarditis(VMC) and to analyze its clinical efficacy on serum cardiac troponin I(cTnI) levels.[Method]in our hospital 52 patients with viral myocarditis 2~4h after admission,and therapeutic evaluation related indicators 15d detection,and their serum concentrations of cTnI were measured in the observed levels.[Results]52 patients treated were cured,31 cases accounted for 59.6%,30.8% effective in 16 cases,5 cases ineffective,the total effective rate was 90.4%.Serum cTnI levels before the treatment of 18.17±6.42μg/L decreased after treatment,3.59±0.94μg/L,two significant differences(P0.05).[Conclusion]In Western conventional therapy based on the use of Health Injection treatment of viral myocarditis can achieve a good therapeutic effect;serum cTnI level may reflect viral myocarditis in patients with myocardial injury,is clinically non-invasive detection and diagnosis of VMC reliable means.
提起虚实,<素问·通评虚实论>之"邪气盛则实,精气夺则虚",已成千古之至理,"病治之大纲",其概念众所周知,毋庸赘述.然<内经>论虚实绝非仅此一端,殊举数则,以补不逮.
温病学说源于内经,发展于金元,日趋完善于明清.近代医家叶天士、吴鞠通各有创建,可谓温病之大师.温病内容浩瀚,病发多见,类型繁多,有风温、温热、瘟疫、温毒、暑温、湿温、秋燥、冬温、温疟.除此尚有春温、伏温、寒湿、湿疟、湿痢、暑风、暑厥、大头瘟、蛤蚂瘟等,概括起来不下20余种,温病名称繁多而杂,对辨证和治疗均有不利.从临床实际出发,为执简驭繁,温病可以概括为温热和湿热两类,其中近而分为风温、春温、暑温、湿温4种,对辨证施治均简单明了,凡属四时温病,均可包函其中.
Objective To observe the effects of compound formula of Chinese herbal benefiting spleen and kidney and invigorating blood on kidney cortex transforming growth factor β1(TGF-β1)and type IV collagen mRNA expression,and probe its mechanism in rats with early diabetic nephropathy(DN).Methods DN is induced by streptozocin(STZ)in rats according to 53 mg/kg i.p,then random by assign to traditional Chinese medicine group(compound formula),western medicine group(Ruitai),model group and normal group.Eight weeks later,measure the expression of the rats kidney cortex TGFβ1 and collagen mRNA of type IV with RT-PCR.Results Compared with the model group,TGFβ1 and collagen mRNA of type IV(P 0.01)is obviously lower in the treating group.And the traditional Chinese medicine group is superior to the western medicine group(P 0.01).Conclusion Compound formula of Chinese herbal can protect kidney,delay pathology damage to kidney,and hold back from DN by lowering expression level of TGFβ1 and collagen mRNA of type IV.
Objective To observe the effects of complex Chinese herbal formula with the actions of tonifying spleen and kidney and invigorating blood on kidney structure and function in rats with early diabetic nephropathy(DN),and to probe its mechanism.Methods Rat models of DN was induced by one-dose streptozocin(STZ)53 mg / kg i.p.Then the rats were randomized into Chinese medicine(complex formula)group,western medicine(Ruitai)group,model group and normal group.Biochemical parameters such as blood sugar,ratio of body weight and kidney weight,serum creatinine(SCr),blood urea nitrogen(BUN)and urinary micro-albumin(UAlb)and the changes of kidney structure in rats with DN were observed.Results Compared with the model group,the damage of kidney structure and the damage of renal function such as blood sugar,UAlb,SCr and BUN were obviously reduced in the other treatment group(P 0.01),and the effect of Chinese medicine was superior to the western medicine(P 0.01).Conclusion Complex Chinese herbal formula has preventive and therapeutic effect on early DN by lowering the blood sugar,UAlb,SCr,BUN,etc.
温病学说源于内经,发展于金元,日趋完善于明清.近代医家叶天士、吴鞠通各有创建,可谓温病之大师.温病内容浩瀚,病发多见,类型繁多,有风温、温热、瘟疫、温毒、暑温、湿温、秋燥、冬温、温疟.除此尚有春温、伏温、寒湿、湿疟、湿痢、暑风、暑厥、大头瘟、蛤蚂瘟等,概括起来不下二十余种,温病名称繁多而杂,对辨证和治疗均有不利.从临床实际出发,为执简驭繁,温病可以概括为温热和湿热两类,其中近而分为风温、春温、暑温、湿温四种,对辨证施治均简单明了,凡属四时温病,均可包函其中.
目的:评价心宁煎剂治疗充血性心力衰竭的临床疗效.方法:将充血性心力衰竭病人按入院先后随机分为治疗组50例,对照组50例.两组性别、年龄、病情无明显差异(P>0.05).两组病人均给予同样的基础治疗,如卧床休息、低盐饮食、吸氧、口服血管紧张素转化酶抑制剂(ACEI)、利尿剂等.在此基础上治疗组加用心宁煎剂100ml,每日3次口服,对照组给予地高辛、硝普钠、多巴酚丁胺、米力农等,治疗4周.结果:治疗组总有效率为94%,对照组总有效率为90%.治疗组无死亡病例,对照组死亡2例.治疗前后比较,两组心功能均显著改善(P<0.01),治疗4周后治疗组较对照组心功能改善更为显著(P<0.05).两组治疗前后左室短轴缩短率(△D%)与二尖瓣-室间隔间距(EPSS)均有显著改善(P<0.01),治疗4周后治疗组较对照组△D%与EPSS改善更为显著(P<0.05).按照明尼苏达生活质量调查表比较治疗前后两组明尼苏达生活质量调查积分,结果显示,治疗后两组生活质量均有显著提高,但治疗组生活质量改善更明显(P<0.05).心肾阳衰是心力衰竭较重阶段的表现特点.心宁煎剂即是根据本病的病机组方.本研究显示心宁煎剂能够调整心肾功能,调节肺、脾、肾三脏之间的平衡,从而改善心肌代谢,增强心脏功能,取得较好的临床疗效.