Objective To investigate the pharmacokinetics of free valproate in the brain tissues and blood of rats after intraperitoneal injection of sodium valproate.Methods Blood-brain microdialysis and HPLC following precolumn derivatization were used to determine the concentration of valproate in microdialysis dialysate of blood and extracellular fluids of hippocampus 240 min after a single intraperitoneal injection in the rats.Pharmacokinetic parameters were calculated with DAS 3.0 software.Results tmax of free valproate in the extracellular fluids of the hippocampus lagged behind that in blood.Cmax and AUC0 ∞ in the extracellular fluids of the hippocampus were lower than those in the blood.Conclusion Microdialysis with HPLC following precolurnn derivatization established in this study can be utilized to successfully determine the pharmacokinetics ofvalproate in rat brain tissues and blood.

目的 探讨抗凝分级管理服务模式,规范抗凝管理工作.方法 根据接受抗凝治疗患者的特殊情况和对药物治疗的不同需求,建立分级管理服务模式,并制定不同服务标准.结果 建立了抗凝管理服务的标准操作程序,规范了抗凝管理服务流程,使抗凝治疗管理服务更趋标准化.结论 抗凝治疗实施分级管理提高了抗凝治疗规范化水平及个体化水平,还有利于临床药师工作的考核评价以及将来药学监护服务的收费.

通过网络对我国独立学院图书馆的数字资源建设现状进行了调查.根据调查结果,采用数据分析法和综合归纳法,从数字资源建设方式与类型方面,分析了独立学院图书馆数字资源的建设现状、存在的问题,提出了改进独立学院图书馆数字资源建设的措施.

Assembly is the last and most important process in discrete manufacturing.In a certain inventory of parts,reasonable assembly plan can improve production efficiency and on-time delivery rat.Emergency orders,lack of parts are unconventionality problems,will disorganize the quondam assembly plan and influence the on-time delivery rat of the conventional order.Assembly planning based on complete kit method can give priority to the emergency order and improve the on-time delivery rat of conventional orders by formulating reasonable,flexible distribution strategy of parts.

经皮内镜下行胃造瘘术以其具有创伤小、安全性好、操作方便快捷、并发症少等优点,在临床上应用日益广泛,是目前常见的治疗消化系统疾病的重要手段。适用于胃肠功能正常、由于各种原因造成经口进食困难,需长期营养支持者,能有效的改善患者的营养状态,延长患者的生命。但由于术后造瘘口及进食方式的改变,常给患者身心带来不适。同时,术后护理质量水平也直接关系到患者的预后。因此,术前应重视患者的心理护理,术后加强饮食护理、造瘘口及造瘘管的护理,预防并发症的发生,做好健康宣教,以确保手术疗效,减轻患者痛苦,从而提高患者的生活质量。

There are several assessing parameters for short time conflict alert(STCA) in air traffic control(ATC) system,such as losing alert rate,false alert rate,etc.Those parameters usually could evaluate STCA function performance except some facets.We proposed a new assessing parameter,inappropriate alert rate(IAR),based on studying on the STCA in real ATC system.With the traditional assessing parameters together,they could give more suitable evaluation for ATC system.The simulation and real data present IAR parameter is a validation and confirmation index for evaluating STCA function in ATC system.

This paper analyses the importance of training programming capability to students of computer major,summarizes the standing problem during the present teaching of high level language program design course,presents reform methods and measures from four links of teaching,practicing,testing and communicating.Base on these research results,the High Level Language Program Design Course Website is studied and designed.It can provide a platform for improving the students'programming capability.

For the rapid design of case erecting machine of packing production line,it researches a rapid search method based on CBR and designs the case-based retrieval of case erecting machine.It sets the weight of case characteristic and the main characteristics of case in rough sets theory,creates similarity model of cases to find the similar cases.Using this search method to the design process of case erecting machine,it achieves the rapid design of case erecting machine through the reuse of the similarity designs.

项目驱动教学法是基于建构主义学习理论与情境学习理论的以学为主导的教学方法,以学生为中心、以活动为中心培养学生主动、积极的完成工作任务来获得知识与技能。在《WEB应用程序开发》课程中引入这一方法,是对传统计算机教学模式改革。文章主要集中于项目驱动教学方法在《WEB应用程序开发》课程的开展与实施。

According to training objective and Course system of computer specialty,the flexible reform of digital logic course is proposed.Furthermore,the details of reform plan are described from three aspects including the teaching content,the teaching method,and the exper imental teaching model.In the process of reform practice,network and virtual reality technology are used to build autonomous learning on line system.In this system,students become cognitive subject,and learning interest of them is aroused.So with the improvement of learn ing initiation and learning interaction,the learning efficiency becomes more and more high.

As the increasing dependence on urban rail transport system and the establishment of an integrated information network,we must take into account the destruction of man-made impact on the system.Now,heterogeneous transport information network composed of various information systems will be estabilished.Compared with the information security issues of the past closed system,large-scale heterogeneous network security issues become more important.So,it is necessary to establish the information security management system of rail transport information systems as soon as possible.Based on the standards ISO27001,this thesis gives a primary planning for the security management system of rail transport information systems.

Information security risk assessment is an important part of information security risk management.To assess the risk of an information system,not only the risks of its independent subsystems,but also the risks caused by the interactions among subsystems should be taken into consideration.Based on the analytic hierarchy process,a quantitative risk assessment method combining entropy weight with triangular fuzzy number is proposed.Triangular fuzzy numbers are used to describe the information that estimated by the information security experts,and the entropy weight is introduced to decrease the subjectivity of conventional weights.Moreover,the effect caused by the complexity of the system on risk occurrence probability is considered as well,that makes the assessment results more reasonable.An example based on Metro information systems is introduced to illustrate the application of the proposed method.

分析三层架构开发技术,通过对高校实验室设备管理系统的需求分析,对系统的数据层、业务层组件进行了规划和设计,并给出整理解决方案和实现。

<正>作为长期工作在信息化一线人员,接触的都是最底层的设计人员,企业正忙于作一些更基础的东西,精益研发一听,感觉离我们工作实际挺远,还有很长的一段路要走。数字化设计制造航天五院最早1988年开始实施AVIDM,到1994年推出设计平台,但是十几年来感觉有点阳春白雪,建设就放得很慢,也不能说完

As the carrier of data transform,the XML describes the data in text.In order to protected the integrality of data from the end to end,XML doucument implements signature.This paper analyzes the technique of XML signature,and puts forward the different solution of XML signture to meet the different application need in auto e-commerce.

This article presents a modified fuzzy C means algorithm on account of the defection of fuzzy C means algorithm and uses genetic algorithm to overcome the short of answer which is only local best answer. Experiment simu-lations prove the availability and feasibility of our mixed algorithm.

很多文献都针对模糊建模进行了研究并且提出了大量的算法。反向传播算法是一种有效的模糊建模方法,在很多场合都有应用。但这种算法在模糊建模过程中存在着潜在的死区、陡峭的推理曲面和灵敏度下降的问题。本文分析了传统反向传播算法的潜在问题并且提出了改进方法,给出了完整的改进BP算法和一些仿真结果。

当大家上网正欢时,突然被一条手机短信打扰,不仅失去了上网的兴致,还得去按小小的手机按键,慢慢地回复短信.其实,大可不必这样费时费力,笔者在浙江出差时学会了一个好方法,不仅高效迅速,最重要的是还可以免费发短信.目前只有浙江的移动用户才能享受到这份免费的午餐.

扩展有限状态机(EFSM)模型在有限状态机(FSM)模型的基础上进行了扩展,通过EFSM模型,可以更加精确的描述软件系统的行为。本文将初始的不确定的扩展有限状态机转换成确定的扩展有限状态机,解决了状态迁移路径不可执行的问题。