Objective To observe state of crystals dissolved by adopting microwave heating to dissolve crystalliza-tion 20% mannitol injection under different fire position of microwave oven .Method Regenerated crystallization of 20% mannitol injection was packaged with soft plastic bag and placed in the microwave oven for heating .After heat-ing ,residual amount of crystallization of 20% mannitol injection was immediately weighed based set heating and time point ,such the defrost ,low ,midst ,high ,highest fire position ,and set up time point t=15 s ,30 s ,45 s… …420 s .In another hand ,kerosene thermometer was used to measure the temperature of solution within the plastic bag at the time point t=120 s ,180 s ,240 s… …420 s .Each experiment is repeated three times at each time point . Result Mannitol crystals are not dissolved completely by heating before bags explosion in different firepower .Quality of crystalline residue is 0 .86 g to 3 .56 g .The solution temperature exceed 90 ℃ by heated to the highest time point (before the bags burst) .Conclusion 20% mannitol injection should not be suitable for microwave heating to dissolve the crystals .Mannitol solution can not be directly removed by hand after heating due to the high temperature and to avoid the possible bag explosion and cause burns personnel .

目的探讨水浴加热方式溶解20%甘露醇注射液内结晶的溶解规律。方法使用电热恒温水箱加热,设定不同温度档,用称量法计算20%甘露醇注射液在每个温度档下不同时间点的残余结晶量。结果当水箱温度为40℃时,经90min能将甘露醇结晶完全溶解;水箱温度为50℃时,经40min后甘露醇结晶完全溶解;水箱温度为60℃时,经30min后甘露醇结晶完全溶解;水箱温度为70℃时,经25min后甘露醇结晶完全溶解;水箱温度为80℃时,经15min后甘露醇结晶完全溶解;当温度设为90℃时,最长不超过10min就能将甘露醇结晶完全溶解。结论随着水箱温度的升高,溶解掉结晶的时间越短。护士可根据此规律,适当提高水浴温度,以减少溶解甘露醇结晶时间,提高临床使用时效。