目的:观察阿托伐他汀对于青少年高血压患者的疗效及对患者血清指标、血压变异性的影响.方法:选择本院收治的128例青少年高血压患者作为研究对象,均分为常规治疗组与阿托伐他汀组(在常规治疗的基础上加用阿托伐他汀治疗);治疗6个月后评估两组临床疗效,比较两组治疗前后动态血压、血压变异指标,及血清胱抑素C(Cy-sC)、同型半胱氨酸(Hcy)、血肌酐(SCr)、血尿素氮(BUN)水平.结果:阿托伐他汀组总有效率显著高于常规治疗组(96.88％ 比76.56％,P=0.001);治疗6个月后,与常规治疗组比较,阿托伐他汀组血清CysC[(1.19±0.29)mg/L比(0.78±0.25)mg/L]、Hcy[(12.04±2.02)μmol/L比(8.98±1.56)μmol/L]、SCr[(86.29±4.52)μmol/L比(83.42±4.16)μmol/L]、BUN[(7.15±0.42)mmol/L比(6.28±0.39)mmol/L]水平均显著降低,24h内血压水平与血压变异性指标、白天血压变异性指标、夜间血压变异性指标均显著下降(P<0.05或<0.01).结论:阿托伐他汀具有辅助降低血压、改善血压变异性和降低血清同型半胱氨酸、血肌酐等的作用.

To observe influence of atorvastatin on incidence rate of short‐and long‐term cardio‐and cere‐brovascular events in patients with hypertensive nephropathy (HNP).Methods :A total of 130 HNP patients treated in our hospital were enrolled ,randomly and equally divided into routine treatment group and atorvastatin group (re‐ceived atorvastatin based on routine treatment ).After three‐month treatment ,renal function ,inflammatory fac‐tors ,vascular endothelial function ,hemorheology ,levels of blood lipids and blood pressure etc .before and after treatment were observed in two groups ;after one‐year follow‐up ,incidence rates of short‐(six months) and long‐term (one year) cardio‐and cerebrovascular events were recorded in two groups .Results : Compared with routine treatment group after three‐month treatment ,there were significant reductions in levels of urinary albumin [ (35. 85 ± 4. 98) mg／ml vs.(29.63 ± 4.51) mg／ml] ,serum creatinine [ (92. 11 ± 10.52) μmol／L vs.(86. 43 ± 10. 16) μmol／L] , blood urea nitrogen [ (8. 16 ± 0. 45) mmol／L vs.(7.19 ± 0. 36) mmol／L] ,serum procalcitonin [ (1. 21 ± 0. 67) ng／ml vs .(0.67 ± 0. 31) ng／ml] ,C reactive protein [(49. 51 ± 8.79) mg／L vs.(33. 37 ± 8.15) mg／L] ,blood pres‐sure [(152.78 ± 4.52)／(94.37 ± 3.69) mmHg vs.(141.89 ± 4.13)／(91.52 ± 3. 24) mmHg] ,blood lipids (except HDL‐C) ,high shear whole blood viscosity ,low shear whole blood viscosity ,hematocrit ,plasma viscosity and fi‐brinogen level in atorvastatin group , P＜0. 01 all.Compared with routine treatment group ,there were significant reductions in incidence rates of short‐ and long‐term unstable angina pectoris ,carotid artery stenosis and coronary stenosis ,and long‐term hemorrhagic stroke in atorvastatin group , P＜0.05 or ＜0.01. Conclusion :Statins can sig‐nificantly reduce incidence rates of short‐ and long‐term cardio‐ and cerebrovascular events in patients with hyper‐tensive nephropathy .

目的 通过对重症监护病房住院患儿医院感染发生情况进行研究,探讨其发病特征,为预防和控制医院感染提供依据. 方法 以2009年6至11月我院重症监护病房872例患儿为研究对象,确定医院感染病例;采用描述性研究方法对ICU发生医院感染患儿进行研究. 结果 ICU医院感染率为11.58%,感染部位以呼吸道为主,病原体致病菌以G-菌为主,其次是G+菌,病毒和真菌也有检出. 结论 合理使用抗菌药将有利于预防和控制儿科医院感染.充分了解医院感染的特征,对易感者实施重点保护,有助于减少医院感染的发生.

高血压病的血管重构与炎性业已证实,尿微量白蛋白的增高也反应了高血压病的早期肾动脉硬化[1],但高敏C反应蛋白(h-CRP)与尿微量白蛋的相关报道尚少,本文就两者的相关性报道如下.

目的:观察头针加体针对痉挛型脑瘫患儿骨代谢变化的影响。方法:将80例痉摩型脑瘫患儿随机分为实验组和对照组各40例。实验组采用头针加体针配合体疗加作业疗法,对对照组只采用体疗加作业疗法。每日1次,30次为1疗程,两组均治疗3个疗程。治疗前后观察患儿骨密度(BMD)、降钙素(CT)、血甲状旁腺激素(PTH)、骨碱性磷酸酶(BALP)等含量的变化。结果:实验及治疗组治疗后BMD、CT明显升高,PTH、BALP明显降低,与治疗前相比有明显差异(P<0.05;P<0.01)。实验组优于对照组。结论:头针加体针配合体疗加作业疗法能改善患儿的骨代谢,治疗痉挛型脑瘫患儿疗效确切。

血管性痴呆是继心、脑血管病、肿瘤之后的第4位死因,已成为威胁高龄人群生命质量的重要疾病之一,目前对该病的研究仍在探讨阶段.近5年来我们运用益智饮治疗血管性痴呆获得较好的临床疗效,现报告如下.

冯某,女,45岁.主因大便秘结5年,加重6个月,于2002-10-12就诊.5年前,患者无明显原因出现大便秘结,大便日行1次,未曾治疗.近2年来,病情加重且时有腹胀、腹痛、嗳气,自己用果导片或番泻叶,大便得通后诸症消失.6个月前,大便四五日一行,用上法无效,即到当地某医院给予清热通腑的中药治疗,病情时有缓解,停药后病情同前.

1992～1997年我们总共治疗慢性乙型肝炎300例,其中运用柴胡桂枝干姜汤加减治疗49例,收到了满意的疗效,现报告如下.