Objective The research aimed at evaluating whether non-invasive endolymphatic MR imaging could be used in aged patients(≥60 years)suffering from Meniere's disease.Methods Under guidance of nasal endoscopy,a diluted gadopentetate dimeglumine injection was administrated through eustachian tube into mid-ear cavity in four patients (≥60 years old) suffered from Meniere's disease.3D-FLAIR MRI scan was performed one day after the administration.Results The administration succeeded through eustachian tube into mid-ear cavity in those four patients.A rise of fluid level on tympanic membrane while administrating a diluted gadopentetated meglumine injection was observed.Imaging of inner ear endolymphatic spaces were visible in vestibule and cochlea in imaging of patient 1.As to patient 2,in cochlea the scala tympani of the first and second turns were enhanced while scala vestibule weren't;Vestibules couldn't be recognized.In images of patient 3,the scala tympani of the three turns in cochlea were enhanced while scala vestibule weren't;Vestibules couldn't be recognized.For Patient 4,in cochlea the scala tympani of the first turn were enhanced while scala vestibule weren't,and the second turn was partially enhanced;and endolymphatic space of vestibule could be distinguished from perilymphatic space.Conclusions This technique could be adopted in investigation of Meniere's disease in elderly patients.MR imaging of endolymphatic spaces in vestibule and cochlea can be visualized,which may partially provide data for diagnosis of Meniere's disease.

Objective To compare the endolymphatic spaces between Meniere's disease (MD) group and normal volunteer group.Methods Patients were performed administration of gadolinium to mid-ear affected by MD via non-invasive method through eustachian tube,and then performed 3D-FLAIR MRI scanning afer one day.After measurement and calculation,the RV and RC (area of endolymphatic space divided by total lymphatic space in vestibule and cochlea,respectively) between the MD group and the normal group were compared.Results The endolymphatic spaces were distinct from perilymphatic spaces in vestibule and cochlea,the average of RV was 0.39,and the standard deviation of RV was 0.07;the average of RC was 0.16,and the standard deviation of RC was 0.05.RV of the MD group had significant difference compared to that of the normal group(t =-6.07,P ＜0.05);RC of the MD group had no significant difference compared to that of the normal group (t =0.783,P ＞ 0.05).According to diagnosis standard raised by Liu F in previous research,the positive ratio of RV was 42.9％,while the positive RC was 9.52％.The two patients during attack period both had positive RVs.Conclusion RV of the MD group had significant difference compared to that of the normal group;RC of the MD group had no significant difference compared to that of the normal group.

目的:对比7.0T与3.0T磁敏感加权成像铁含量测量的差异,并积累超高场磁共振神经成像经验.方法:50例老年志愿者(年龄52～68岁,男36例,女14例)分别在7.0T和3.0T磁共振成像系统上行常规颅脑磁共振成像及磁敏感加权成像(SWI).对比不同场强下的图像质量,测量受试者双侧苍白球、壳核、尾状核头、黑质、红核以及丘脑的大小及相位值,同时测量受试者各核团铁含量.结果:①幅度图上,7.0T影像能提供更多细节,并可区分核团亚分区(P＜0.05)；②7.0T下可辨识的ROI范围较3.0T下的略大,不同场强的各核团ROI范围差异有统计学意义(P＜0.05)；③除苍白球外,壳核、尾状核头、黑质、红核及丘脑3.0T和7.0T比较,铁含量测量值差异均有统计学意义(P＜0.05).结论:7.0T磁共振磁敏感成像可提供更多解剖细节,SWI脑铁含量测量值与3.0T可能存在差异.