Objective To evaluate the efficacy and safety of solifenacin in patients with overactive bladder (OAB). Methods A multicenter clinical trial was conduced. 216 patients with OAB were enrolled. All the patients received solifenacin(5 mg once daily). With 5 weeks'treatment, all the patients recorded the diary and the adverse events as well. The symptoms of urgency, frequency, nocturia, urine volume, incontinence were evaluated. The results of the efficacy and safety were analyzed by using SPSS 13. 0. Results After 5 week treatments, all the index obviously improved(P<0.05). 187 cases (86.7%)were cured and 43 cases recovered normal voiding, 29 cases improved obviously. 11cases(5.0 %)reported adverse effect as dry mouth, dry eye. Conclusion Solifenacin could be the safe and effective drug in the treatment of OAB patients.

Objective:To investigate a new method of pneumatic ballistic lithotripsy for the treatment of bladder calculi.Methods:A ureteroscope or nephroscope was inserted into the bladder via outer sheath of resectoscope.Then pneumatic ballistic lithotripsy was performed under endoscope to fragment with self-made closure and remove bladder stones.Results:Thirty cases were treated successfully in a single procedure without bleeding,bladder perforation and overhydration.The mean time of lithotripsy was 20 minutes.Conclusion:This method might be effectve with simple,less complication and good effect that could be used in clinic.

1996年3月～2004年8月我院收治睾丸扭转19例,均采用彩色多普勒血流显像(CDFI)检查,提高了早期诊断的准确率,有效降低了睾丸摘除率.现报告如下.

Objective:To study expression of p53 and cyclin E in renal cell carcinoma.Methods:The expression of p53 and cyclin E in 46 renal cell carcinomas and 15 normal renal tissue were examined by immunohistochemical procedures.Results:No significant correlation between cyclin E positive expression and histologic type,tumor grade and clinical stage were found.p53 was positive related to the clinical stage.There was good correlation for the expression between p53 and cyclin E in renal cell carcinoma.When both were positive,the 5-years survival rate was lower than others.Conclusion:Cyclin E and p53 may be the useful prognostic indicator of renal cell carcinoma.

1病例资料 [例1]男,72岁.因间歇无痛全程肉眼血尿伴尿频、尿急2周入院.胸部X线片检查未见明显异常.

Objective:To explore the expression of p73 protein and p53 protein in renal cell carcinoma (RCC) and analyze the correlation among clinical stage, pathologic grade and prognosis in RCC. Methods:Immuno histochemical method was used in 46 cases of RCC. Results: No significant correlation was found among p73, p53 positive expression and pathologic type, pathologic grade ( P 0.05 ). p73 and p53 were positively related to the clinical stage ( P 0.05 ). There was good correlation between the positive expression of p73 and p53 proteins and prognosis in RCC. Conclusion: The positive expression of p73 and p53 protein has no relation with pathologic type and pathologic grade, but with clinical stage. The survival rate of the patients with p73,p53 positive expression was significantly lower than that of the other patients, which might have a practical significance in assessing the prognosis of RCC.