Objective To provide a normal range of serum inhibin B level and evaluating clinical testicular functions.Methods From August 2006 to August 2011,a total of 917 healthy Chinese prepubertal boys were selected for an examination or phimosis.And they divided into 12 groups according to age during each year.Serum inhibin B was measured by enzyme-linked immunosorbent assay (ELISA).All records were imported into a database for statistical analyses.Results The serum inhibin B level peaked by 1-year-old (112.42 ± 15.35) pg/ml.Afterward it decreased in 1-2 years old boys (72.97 ± 7.97) pg/ml.An nadir was observed in those 4-year-old boys (37.06 ± 5.19) pg/ml and maintained a platform low level until 11-12 years of age before its rise.Conclusions As an important predictor for assessing Sertoli cell function,serum inhibin B may be detected in prepubertal boys of all ages.

由于青春期前睾丸产生精子的机制尚未激发,无法像成人那样依据精液分析来评估睾丸功能;青春期前雄激素和促性腺激素水平极低、不具有实际检测意义,或需要预激并多次采血检测,故成人广泛开展的常规生殖激素检测项目(T、FSH、LH等)对评估儿童睾丸功能的作用也不大;临床诊断“金标准”——睾丸活检术属有创性操作,可能导致并发症,实施于儿童的接受度低,临床符合适应证的病例极少.如何准确、微创、便捷地评价青春期前的睾丸功能一直是临床难题.近年来随着对抑制素B(Inhibin B)的深入研究,发现通过评估该激素血清水平,能对青春期前睾丸功能的评价提供较好的参考价值.本文回顾近年来相关的国内外文献,旨在总结抑制素B临床应用的最新进展.

OBJECTIVE:The purpose of this prospective study was to investigate the presence of human papillomavirus (HPV) in tonsillectomy and adenoidectomy specimens from pediatric patients without juvenile-onset recurrent respiratory papillomatosis (JORRP), so as to understand the effect of HPV infection in the upper respiratory tract in children.METHODS:Two hundred and forty-one pediatric patients without known JORRP or other HPV-related diseases undergoing tonsillectomy and/or adenoidectomy for hypertrophy or chronic tonsillitis were enrolled in this prospective study. One hundred and seventy-seven fresh samples of tonsillar tissues and 195 samples of adenoid tissues were collected and then examined for the presence of HPV DNA with the polymerase chain reaction (PCR) technique and typing. Laryngeal papilloma specimens from 17 patients obtained during routine debulking procedures were also analyzed and served as positive controls.RESULTS:All 17 papilloma specimens were positive for HPV DNA and the type was 6 or 11. This result confirmed that the methods used were valid for detecting HPV infection. HPV DNA was detected in 2 of the 177 tonsillar specimens and zero of the 195 adenoid specimens. The two positive samples were confirmed with typing. One was positive for HPV6 and the other for HPV11. Review of the medical records of these two cases confirmed that there were no history of HPV-related diseases. Histologic analysis of their specimens showed lymphoid hyperplasia, no specific changes suggesting HPV infection and no signs of malignancy. The HPV infection rate in upper respiratory tract was 0.8% (2/241).CONCLUSION:There is HPV infection in upper respiratory tract in Chinese children without JORRP, but maybe is not sufficient for the formation of JORRP.

<正>胆脂瘤型中耳炎易引起耳聋和多种颅内外并发症,造成严重后果,应尽早手术治疗。儿童患者临床表现复杂,不同于成人,早期诊断往往比较困难。本次研究对26例儿童胆脂瘤型中耳炎进行回顾性分

患儿男,3天.因颈部肿块3 d,气促少动1 d于2004年12月25日入院.患儿出生时父母就发现左颈部有一肿块,直径约1.5 cm大小,哭闹时明显,无发热气促等情况.出生第3天肿块明显增大,并出现气促、少吃、少哭、少动,遂来我院门诊并收入新生儿病房.入院体检:心率146次/min,呼吸42次/min,血压64/36 mmHg(1 mm Hg=0.0133 kPa),体温37℃,反应较差,哭声低、嘶哑,气略促,三凹征明显,唇略紫,触诊气管居中,左颈部可及一囊性皮下肿块,直径约4 cm,边界清,固定,表面皮肤无红肿;两肺呼吸音粗,有哮鸣音.