Genome-wide association studies (GWASs) have identified numerous genomic loci linked to schizophrenia (SCZ), while their pathogenic mechanisms largely remain unclear. This study demonstrated protein arginine methyltransferase 7 (PRMT7) as a key target of SCZ risk SNPs with allele-specific enhancer activity at 16q22.1. Downregulating PRMT7 in neural progenitor cells (NPCs) decreased proliferation, increased neuronal differentiation, and also led to longer neurites in these neurons. Conversely, overexpressing PRMT7 enhanced NPC proliferation and reduced neuronal differentiation. In three-dimensional (3D) cerebral organoids, similar NPC phenotypic changes were noted following PRMT7 depletion. Mechanistically, PRMT7 regulates the expression of genes related to the cell cycle and neuronal functions, such as CDKN2A and SYP, via symmetrical di-methylation at arginine 3 of histone 4 (H4R3me2s) modification in their promoters. Notably, these genes have a stronger association with SCZ compared to other mental disorders. Together, the results of this study reveal that PRMT7 is a functional gene at 16q22.1, contributing to the etiology of SCZ by modulating NPC proliferation and differentiation as an epigenetic regulator.

Psychopathy is often conceptualized as an antisocial construct, with limited attention given to its expression of prosocial behaviors. This study investigated how interdependent and independent self-construal moderate the relationship between psychopathic traits and different forms of prosocial behavior in a large Chinese community sample (N = 1,519). Using a three-factor model of psychopathy (Egocentricity, Callousness, Antisocial), our analyses revealed that interdependent self-construal significantly moderated the expression of egocentric traits. Specifically, interdependence strengthens the positive association between egocentricity and public prosocial behaviors while attenuating its negative links to anonymous and altruistic prosocial behaviors. The moderating role of independent self-construal was less consistent, weakening the negative effects of egocentricity traits on altruistic helping while strengthening the antisocial traits negative links. These findings support the moderatedexpression model of psychopathy, highlighting self-construal as critical contextual cues that moderate the expression of psychopathic traits relating to prosocial behaviors. Implications for the role of sociocultural factors in understanding prosociality among individuals with psychopathic traits are discussed.

Objective This study investigates the efficacy of an InterRhythmic Care (IRC) for major depressive disorder (MDD). There is a lack of clinical studies on its effect on depression. Methods In this eight-week, randomized, single-blind, controlled trial, 120 patients with MDD were randomly assigned to receive IRC or Internet general psychoeducation (IGP). Participants’ depressive and anxiety symptoms, interpersonal relationships, social function, and biological rhythms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), Interpersonal Comprehensive Diagnostic Scale (ICDS), Sheehan Disability Scale (SDS), and Morning and Evening Questionnaire (MEQ) at baseline and the 8th week. Results Compared to participants in IGP, participants in IRC had lower HAMD total scores, anxiety/somatization, weight, cognitive disturbance, retardation, and sleep disturbance subscores in patients with MDD (F = 190.94, p Bonferroni < 0.001; F = 83.13, p Bonferroni < 0.001; F = 4.15, p Bonferroni = 0.048; F = 65.42, p Bonferroni < 0.001; F = 53.15, p Bonferroni < 0.001; F = 67.76, p Bonferroni < 0.001, respectively);HAMA total score, somatic anxiety subscore, psychogenic anxiety subscore (F = 142.97, p Bonferroni < 0.001; F = 111.06, p Bonferroni < 0.001; F = 128.04, p Bonferroni < 0.001); ICDS total score and subscores for conversation, making friends, manners; and SDS subscores for work/school, social life, family life, and days underproductive (F = 17.38, p Bonferroni <0.001; F = 14.61, p Bonferroni < 0.001; F = 10.97, p Bonferroni = 0.001; F = 11.74, p Bonferroni = 0.001; F = 4.85, p Bonferroni = 0.031; F = 16.29, p Bonferroni < 0.001; F = 12.11, p Bonferroni = 0.001; F = 8.3, p Bonferroni = 0.005) at the end of the intervention period. Conclusions IRC helped patients with MDD improve clinical symptoms, including depressive and anxiety symptoms, interpersonal problems, and social function.

Introduction Drivers for remission, relapse and violence-related behaviour among patients with schizophrenia are the most complicated issue.Methods and analysis This study aims to recruit a longitudinal cohort of patients with schizophrenia. Two suburban districts and two urban districts were randomly selected according to health service facilities, population, geographical region and socioeconomic status. Individuals (>18 years old) who received a diagnosis of schizophrenia following the International Classification of Diseases (10th edition) criteria within the past 3 years will be invited as participants. Assessments will be carried out in local community health centres. Data will be used to (1) establish a community-based schizophrenia cohort and biobank, (2) prospectively determine the course of multidimensional functional outcomes of patients with schizophrenia who are receiving community-based mental health treatment, and (3) map the trajectories of patients with schizophrenia and prospectively determine the course of multidimensional outcomes based on the differential impact of potentially modifiable moderators.Ethics and dissemination The study has been reviewed and approved by the Human Research Ethics Committee of Shanghai Mental Health Center (2021-67). Results of the study will be disseminated through peer-reviewed journals. If effective, related educational materials will be released to the public.

ObjectiveTo explore the relapse status based on the positive and negative syndrome scale （PANSS Scale） and related factors of schizophrenics in Shanghai communities， and to analyze the association between socio demographic characteristics， lifestyles， clinical characteristics and relapse.MethodsA dynamic cohort prospective study design was used in this study. From March 2018 to February 2019， a total of 189 schizophrenics in Xuhui， Hongkou， Changning， Jiading， Songjiang and Baoshan districts were enrolled successively. Baseline questionnaires were conducted through face-to-face interviews at baseline， which contained social demographic information， lifestyle information and clinical information. A follow-up was conducted every 2 weeks for a measurement of PANSS Scale for a total of 6 months. Relapse was assessed by a PANSS score increase of ≥25% from baseline （or an increase of 10 points or more if the baseline score was ≤40 points）. Univariate and multivariate Cox regression models were used to analyze the associations between relapse status （assessed by PANSS Scale） and socio demographic characteristics， lifestyles， and clinical characteristics， respectively.ResultsA total of 165 community schizophrenics completed baseline and follow-up surveys， with a loss to follow-up rate of about 12.7%. After exclusion of sociodemographic and clinical information deficits， 132 patients were included in the analysis totally， with an average age of 48.18±12.67 years， among whom 41.67% were male. Totally 33 patients relapsed during the 6-month follow-up period， with a relapse rate of 25.0%. After adjusting for gender， family history， age， employment， education， marital status， smoking， drinking， exercise frequency， medication compliance， insight， social function， violence history， stress recent events， adverse drug reactions and baseline scores of PANSS Scale， risk factors of relapse included the following four factors： age below 40 years （HR=4.47， 95%CI： 1.15-17.40）， primary school or below （HR=7.11， 95%CI： 1.54-32.83）， unemployed （HR=8.34， 95%CI： 1.78-38.98）， and adverse drug reactions （HR=5.02， 95%CI： 1.75-14.37）.ConclusionWe should pay attention to the risk factors such as age， education， employment and adverse drug reactions， in order to identify high-risk patients and to conduct timely interventions during the relapse management of schizophrenics in Shanghai community.

ObjectiveTo explore the effect of paliperidone palmitate treatment on schizophrenic patients in the community.Methods446 schizophrenic patients who used paliperidone palmitate injection were selected in Shanghai. Before and after the treatment， the disease family burden scale， the concise evaluation scale of drug treatment compliance， the VAS100 score of treatment satisfaction， the short form of quality of life measurement scale， and the screening scale of social function defects were used to evaluate the effects of paliperidone palmitate injection. The data were statistically analyzed using SPSS 26.0 software.ResultsAfter using paliperidone palmitate injection， the total score of family burden （13.94±12.17）， the score of daily family activities （3.26±2.74）， the score of family entertainment activities （2.21±2.30）， and the score of family relationship （2.79±2.76） were significantly higher than those before the treatment （14.98±12.64， 3.51±2.88， 2.48±2.38， 3.11±2.87， respectively， all with P<0.05）. The scores of the World Health Organization on quality of life brief scale （62.89±11.94） and the medication compliance scale （28.11±5.64） were better than those before treatment （60.67±12.62 and 27.37±6.96， all with P<0.05）. Compared with the prior treatment without paliperidone palmitate injection， the number of readmissions after treatment was significantly reduced （P<0.01）.ConclusionThe treatment of paliperidone palmitate injection has significant effect， which can effectively reduce the disease family burden of Schizophrenic patients， improve their quality of life， enhance their drug compliance， reduce the readmission rate of patients， ensure long-term treatment effect and promote disease recovery.

BackgroundAlcohol use disorder （AUD） is a type of chronic relapsing brain disorder. Genetic factors play an important role in the pathogenesis of AUD. And screening for molecular markers of AUD is of great significance for further elucidating the pathogenesis of the disease， discovering novel therapeutic targets and preventing relapse.ObjectiveTo explore relevant hub genes and potential signal pathways associated with the development of AUD through bioinformatics analysis， and to provide a new direction for the prevention and treatment of AUD.MethodsThe GSE161986 dataset was acquired from the Gene Expression Omnibus （GEO） database. The limma package in R was utilized to identify differentially expressed genes （DEGs）. Gene set enrichment analysis （GSEA） was carried out using the Database for Annotation， Visualization and Integrated Discovery （DAVID）. A protein–protein interaction （PPI） network of DEGs was assessed using the STRING database and visualized by Cytoscape software. Finally， hub genes were validated in GSE44456 dataset.ResultsA total of 114 DEGs were identified. GSEA revealed that these genes were mainly involved in the regulation of signal transduction， protein binding， membrane trafficking and MAPK signaling pathway. PPI network and validation study indicated that GAD1， TIMP1 and CD44 were potential hub genes involved in AUD.ConclusionAberrant expression of GAD1 and TIMP1 as well as MAPK signaling pathway may play a key role in the pathogenesis of AUD， and may serve as potential molecular targets for the diagnosis and treatment of AUD. ［Funded by "Flying Project" of Shanghai Mental Health Center （number， 2022-FX-01）］

Objective:Compared to imprecisely repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC), this study aimed to explore whether localizing the DLPFC precisely or targeting on the right orbital frontal cortex (rOFC) can improve the rTMS efficacy for the treatment of depressive disorder.Methods:From January 2018 to March 2021, this study recruited patients who met the DSM-Ⅳ diagnostic criteria for depressive disorder in Shanghai Mental Health Center. Nineteen patients were located in the imprecise DLPFC group, 19 patients in the precise DLPFC group, and 14 patients in the rOFC group. All patients were assessed by the 17-item Hamilton Depression Scale (HAMD 17) and Hamilton Anxiety Scale (HAMA) at baseline and after 10-session rTMS treatments. The primary outcome of this study was the HAMD 17 response rate, and the second outcome included the reduction score and reduction ratio of the HAMD 17/HAMA. Results:At baseline, there was no significant group difference in HAMD 17 or HAMA scores among the three groups. After the rTMS treatment, the HAMD 17 response rate was significantly different among the three groups (χ2=6.86, P=0.032). The HAMD 17 response rate in the precise DLPFC group (74%) was significantly higher than that in the imprecise DLPFC group (32%, χ2=6.76, P=0.011), but was comparable with that in the rOFC group (57%, χ2=2.16, P=0.133). HAMD 17 response rate did not significantly differ between the precise DLPFC group and the rOFC group (χ2=0.99, P=0.266). The HAMD 17 reduction score tended to be significantly different among the three groups ( F=2.95, P=0.062), with the precise DLPFC group presented the highest HAMD 17 reduction score. There were no significantly differences in the reduction score of HAMD and the reduction ratio of HAMA and HAMD 17 among the three groups. Conclusions:Precisely localizing the DLPFC target may be helpful to improve the rTMS efficacy for the treatment of depressive disorder, while rOFC may be a candidate target for rTMS treatment of the depressive disorder.

目的:构建精神分裂症患者社区综合风险预测模型.方法:以疾病监测系统中完成随访的7944例精神分裂症患者为建模队列,并随机抽取其中20％(1603例)作为验证队列,在2018年4月收集基线资料,7月、10月收集随访数据.基于建模队列数据,用logistic回归模型分析暴力行为的影响因素.用纳入模型的危险因素系数β建立风险评分表,以AUC评价其预测能力,用验证队列验证外部预测准确性,用所建模型对建模队列患者进行风险等级划分.结果:纳入精神分裂症社区管理风险的因素有11个.建模队列AUC=0.78(95％CI:0.74-0.81),风险评分＞14分提示患者处于暴力行为高风险,模型敏感度62％,特异度88％,准确度87％.经所建模型划分风险等级,其中高风险占3.2％,较高风险占11.0％,一般风险占69.2％,较低风险占16.6％.结论:基于社区监测的精神分裂症患者暴力行为综合风险模型预测能力较好,简单易行,在精神障碍防治中有一定应用价值.

目的 分析上海市社区精神分裂症患者近期应激事件与危险行为发生的关联.方法 以上海市徐汇区、虹口区、嘉定区随访管理的9520名精神分裂症患者为研究对象,2018年4月通过问卷调查收集一般人口学特征、服药情况、自知力情况、涉及暴力的精神症状、社会功能、监护情况和最近3个月内应激事件发生情况,2018年7月和10月随访危险行为发生情况.采用多因素Logistic回归方法分析近3个月应激事件发生情况(无/轻微/严重)与危险行为的关系,并按年龄、性别等特征进行亚组分析.结果 共纳入7955名研究对象进行分析,随访6个月期间,共观察到危险行为发生有203例,发生率为2.55％.多因素调整相关因素后,以近3个月无应激事件的患者为参照,有轻微应激事件的患者危险行为发生风险是其7.18倍(95％CI:4.17～12.37),有严重应激事件的患者危险行为发生风险是其9.33倍(95％CI:2.33～37.41).分层分析结果提示,在教育程度为初中和高中的分层中,存在近3个月应激事件的患者发生危险行为风险分别是无应激事件患者的7.37倍(95％CI:3.27～16.61)和21.65倍(95％CI:8.95～52.40);而在教育程度为小学及以下的患者中,这一比值是2.32(95％CI:0.19～27.88,Pfor interaction=0.010).在规律服药的分层中,存在近3个月应激事件的患者发生危险行为风险是无应激事件患者的12.61倍(95％CI:6.95～22.88);而在未规律服药的患者中,经历应激事件者发生危险行为的风险是未经历者的2.86倍(95％CI:0.82～9.97,Pfor interaction=0.015).结论 在上海市社区精神分裂症患者的队列研究中,存在近3个月应激事件是患者危险行为的危险因素,且这种负性影响在中学学历和服药规律的患者中被增强.

目的 了解2020年上海市精神卫生资源配置现状与公平性,为精神卫生工作规划和政策制定提供数据支持.方法 收集2020年上海市精神卫生资源现状问卷调查结果,包括精神卫生医疗机构、实际开放床位、精神科执业(助理)医师和注册护士资料,采用洛伦兹曲线和基尼系数评价上海市精神卫生资源按人口和地理面积配置的公平性.结果 2020年上海市共有精神卫生医疗机构96家,精神科实际开放床位15 060张,精神科执业(助理)医师1 257人,注册护士2 887人,医护比为1∶2.30.每万人和每平方千米拥有的精神科实际开放床位、执业(助理)医师和注册护士均为中心城区最多.每万人配置精神科实际开放床位、执业(助理)医师和注册护士分别为6.06张、0.51人和1.16人,基尼系数分别为0.36、0.42和0.44.每平方千米配置精神科实际开放床位数、执业(助理)医师数和注册护士分别为2.38张、0.20人和0.46人,基尼系数分别为0.72、0.76和0.75.结论 2020年上海市精神卫生资源按人口、地理面积配置总体上处于不公平状态,公平性较2015年总体有所上升,按地理面积配置的公平性低于按人口配置的公平性.

目的 分析2012-2018年上海市严重精神障碍应急事件特征,为严重精神障碍防治提供科学依据.方法 梳理上海市2012-2018年10620起经应急处置的严重精神障碍应急事件,分析不同患者、不同地区、不同年份应急事件的分布特征.结果 2012-2018年上海市严重精神障碍应急事件共10620起.其中男性5745起(占54.09％),女性4875起(占45.91％);年龄为16～98岁,平均年龄(52.38±13.08)岁;贫困人员占3243起(30.54％),非贫困占7377起(69.46％).10620起突发事件以精神分裂症患者引起为主(8315起,占78.30％),36～59岁患者最多(6368起,占59.96％).应急事件以病情复发或先兆(4304起,占40.53％)、危害公共安全或他人安全的行为或风险居多(3899起,占36.71％).危害公共安全或他人安全的行为或风险方面,男性比例高于女性,年纪轻的患者比例高于年长患者,偏执型精神病、未确诊患者比例高于其他患者.发生2次及以上应急事件的患者占人数的26.54％,应急事件则占总数的49.23％.对患者的处置措施主要以紧急住院和现场处置为主,处置性质主要以保护性治疗为主,处置效果以"有效"为主.徐汇区严重精神障碍应急事件发生率最高,金山区最低.应急处置突发事件总量从2012-2015年呈逐渐增加趋势,其后基本维持在较高的数量.结论 上海市目前对严重精神障碍的应急处置流程发挥了稳定且重要的作用;预防病情复发和危害公共安全是严重精神障碍应急事件防控的重点内容,应加强早期监测、识别、预警报告及其干预;精神卫生防治人员应重点关注既往发生过应急处置的精神分裂症患者,在今后的工作中进一步加强工作人员的应急处置综合管理和协同能力.

目的 了解上海市心理卫生服务机构的伦理规范状况,为规范心理卫生服务机构的行为提供决策依据.方法 对上海市心理卫生服务行业协会107家会员机构进行问卷调查,分析不同类型、不同开设形式的机构在伦理规范上的差异.结果 不同类型的机构在避免双重关系、公示对外收费两项伦理要求的规定上差异有统计学意义(P<0.05),非医疗企事业单位设置比例较低(20.0％);不同开设形式的机构在职业培训、工作流程、专业核查3个伦理要求的规定上差异有统计学意义(P<0.05),联合开设的机构伦理规范相对欠缺.结论 非医疗企事业单位对双重关系问题重视不足,收费透明度有待提高.联合开设机构缺乏完善的职业培训和工作流程,专业核查制度欠缺.心理卫生服务行业协会需加强监管,规范心理卫生服务机构行为.

惊恐障碍又称急性焦虑障碍.其主要特点是突然发作的、不可预测的、反复出现的、强烈的惊恐体验,一般历时5～20分钟,伴濒死感或失控感,患者常体验到濒临灾难性结局的害怕和恐惧,并伴有自主神经功能失调的症状. 一、临床表现 惊恐障碍的特点是莫名突发惊恐,随即缓解,间歇期有预期焦虑,部分患者有回避行为. 1.惊恐发作 这是一种突如其来的惊恐体验,仿佛窒息将至、疯狂将至、死亡将至.患者宛如濒临末日,或奔走、或惊叫,惊恐万状、四处呼救.惊恐发作时伴有严重的自主神经功能失调,主要有三个方面:①心脏症状:胸痛、心动过速、心跳不规则;②呼吸系统症状:呼吸困难;③神经系统症状:头痛、头昏、眩晕、晕厥和感觉异常.

Given the importance of the cerebellum in the pathophysiology of schizophrenia, the cerebellar vermis has been proposed as a new rTMS stimulation site for negative symptoms. In this study, 64 patients from 7 psychiatric hospitals were randomized into the study (n=32) or control (n=32) group. Intermittent theta burst stimulation (iTBS) (or sham stimulation) to the cerebellar midline was administered 5 times/week for 2 weeks. Psychotic symptoms were assessed with the Positive and Negative Symptoms Scale (PANSS) at baseline, the end of treatment, and 2, 6, 12, and 24 weeks after the treatment. Regarding the negative symptoms, the interaction effect between group and time was statistically significant, with the scores in the study group significantly lower than those in the control group at the 4 follow-ups after treatment, and the group difference was maximal at 24 weeks of follow-up. The main effect of time was significant; however, the main effect of group did not show statistical significance. Our study revealed that cerebellar iTBS may improve negative symptoms in schizophrenia patients, and the effect was more pronounced at 24 weeks after the end of treatment, which provides preliminary empirical evidence for the maintenance of efficacy after stimulation of this new site.

目的 系统总结棕榈酸帕利哌酮(PP1M)治疗精神分裂症的药物经济学相关研究结果,为抗精神病药的临床应用提供依据.方法 系统检索Taylor&Francis、ScienceDirect、PubMed、Embase、CBM、中国知网和万方数据库等,检索时间从建库至2019年12月,纳入2015～2019年棕榈酸帕利哌酮(PP1M)药物经济学相关的文献,并参照综合卫生经济学评价报告准则(CHEERS)量表评估文献质量.结果 共纳入14篇对照研究,主要评价内容包括棕榈酸帕利哌酮(PP1M)相比其他抗精神病药在疗效、成本节约和质量调整生命年(QALYs)等方面的差异.多数研究结果支持棕榈酸帕利哌酮(PP1M)更具优效性,且通过敏感性分析验证了结果的稳定性.结论 当前抗精神病药物中,棕榈酸帕利哌酮(PP1M)在治疗精神分裂症方面具有良好的药物经济学优势,同时棕榈酸帕利哌酮(PP3M)的成本效果优势较为明显.

OBJECTIVE:Antipsychotic drugs are widely used for treating patients with first episode of psychosis, targeting threshold psychotic symptoms. The clinical high risk of psychosis is characterized as subthreshold psychotic symptoms and it is unclear whether they can also benefit from antipsychotic drugs treatment. This study attempted to determine whether initiating antipsychotic drugs treatment in the clinical high risk of psychosis phase was superior to initiating antipsychotic drugs treatment in the first episode of psychosis phase, after the 2-year symptomatic and functional outcomes.METHOD:Drawing on 517 individuals with clinical high risk of psychosis from the ShangHai At Risk for Psychosis program, we identified 105 patients who converted to first episode of psychosis within the following 2 years. Patients who initiated antipsychotic drugs while at clinical high risk of psychosis (CHR_AP; n = 70) were compared with those who initiated antipsychotic drugs during a first episode of psychosis (FEP_AP; n = 35). Summary scores on positive symptoms and the global function scores at baseline and at 2 months, 1 year and 2 years of follow-up were analyzed to evaluate outcomes.RESULTS:The CHR_AP and FEP_AP groups were not different in the severity of positive symptoms and functioning at baseline. However, the CHR_AP group exhibited significantly more serious negative symptoms and total symptoms than the FEP_AP group. Both groups exhibited a significant reduction in positive symptoms and function (p < 0.001). Repeated-measures analysis of variance revealed group by time interaction for symptomatic (F = 3.196, df = 3, p = 0.024) and functional scores (F = 7.306, df = 3, p < 0.001). The FEP_AP group showed higher remission rates than the CHR_AP group (χ2 = 22.270, p < 0.001). Compared to initiating antipsychotic drug treatments in the clinical high risk of psychosis state, initiating antipsychotic drugs treatments in the first episode of psychosis state predicted remission in a regression model for FEP_AP (odds ratio = 5.567, 95% confidence interval = [1.783, 17.383], p = 0.003).CONCLUSION:For clinical high risk of psychosis, antipsychotic drugs might be not the first choice in terms of long-term remission, which is more reasonable to use at the first episode of psychosis phase.

目的 探讨精神病人刑事责任能力评定量表(RSCRs)在司法精神病鉴定中的应用和价值.方法 对97例鉴定诊断为患精神疾病者的刑事责任能力鉴定案例进行RSCRs评分,与专家鉴定意见对刑事责任能力的评定结果进行比较.结果 RSCRs总分与条目11为中等程度相关(P<0.01),总分与其余17个条目均为强或极强相关(P<0.01).不同刑事责任能力等级间RSCRs评分比较差异有统计学意义(P<0.01).RSCRs等级划分结果与专家鉴定意见的一致性尚可(Kappa值=0.73,P<0.01).探索性因素分析提取2个因子,累积贡献率为72.049％.结论 精神病人刑事责任能力评定量表在司法鉴定实践中可作为参考工具,但目前仍难以取代鉴定专家评定.

目的 了解基于"知信行"模式的依从性干预对精神分裂症患者的作用.方法 将符合入组标准的203例社区精神分裂症患者采用随机数字表法分为干预组(n=98)和对照组(n = 105).对照组接受常规社区精神卫生服务,干预组则在此基础上进行"知信行"模式的依从性干预,为期6个月.在干预前、后分别采用阳性与阴性症状量表(PANSS)、生活质量量表(SQLS)以及自编精神分裂症知识、态度和行为问卷对患者进行评估.资料采用EpiDate 3.1软件建立数据库并录人,用SPSS 21.0软件进行统计分析.结果 人组时,两组患者各量表评分差异均无统计学意义(P＞0.05).干预后,干预组知信行问卷得分(8.33±1.14)分、PANSS总分(47.06±6.87)分、阴性症状得分(12.44±3.12)分、心理社会分量表得分(27.64±16.18)分、动机/精力分量表得分(40.74±11.76)分均明显优于对照组的(7.51±1.80)分、(49.18±7.84)分、(13.41±3.77)分、(35.48±18.31)分、(47.48±12.61)分,差异有统计学意义(P＜0.05).干预后,干预组规律服药率(95.92％)明显高于对照组(85.71％),差异具有统计学意义(P＜0.05).结论 基于"知信行"模式的依从性干预对提高患者治疗依从性、缓解病情及改善生活质量具有积极作用.

目的 分析2011-2018年我国精神卫生床位资源配置的公平性,为政府优化资源配置提供参考依据.方法 查阅《中国卫生统计年鉴》等相关资料,对比分析2011年和2018年我国精神卫生床位资源配置的情况,采用基尼系数、泰尔指数评价精神卫生床位资源按人口和地理面积配置的公平性.结果 2011-2018年我国精神卫生床位资源配置总量呈上升趋势,按人口配置和按地理面积配置的公平性水平均有所提升,按人口配置的公平性优于按地理面积配置的公平性,资源配置的不公平性主要来自于组内差异.结论 在未来精神卫生床位资源配置相关政策的制定中应兼顾服务人口和面积,提升按地理面积配置的公平性,缩小东、中、西部地区内部差异.