Influenza incidence has been proven to be closely associated with low temperatures. However, the role of temperature fluctuations in affecting influenza incidence is less quantified, especially in the context of global warming. This study constructed a short-term weather variability index (SWVI) to measure the cumulative fluctuations of minimum temperature between 2 consecutive weeks and comprehensively analyzed the impact of SWVI on current and future risks of influenza incidence in the mid-latitude region of Hubei Province, China. Influenza-like illnesses (ILI) data (2009-2020), meteorological observation data from 76 national stations (1979-2020), 10 global climate models in the Coupled Model Intercomparison Project Phase 6 (CMIP6) and distributed lag nonlinear modeling were used for analysis. The results showed that (1) the intra-annual variation of SWVI and the percentage of ILI (ILI%) in Hubei exhibited similar bimodal structures. A more significant correlation was detected between SWVI and ILI% than with sustained low temperatures, suggesting that SWVI may serve as a stimulus for influenza incidence. (2) From winter to spring, the response of relative risk (RR) of ILI% to SWVI was faster and greater than to low temperature. The most significant impact of SWVI on influenza incidence was observed at a short-term lag of 0 wk, with the highest increase in RR of ILI% recorded at 84.1% (95% confidence interval [CI]: 25.7-169.6%) for each 1 degrees C increase in SWVI. In age-stratified analysis, younger people were more susceptible to weather variability than the elderly. (3) In the past 40 yr, the annual SWVI increased consistently, particularly in central and eastern Hubei. CMIP6 projections showed that SWVI would continue to increase with a stronger amplitude under scenarios of higher emissions. The risk of influenza incidence caused by short-term weather variability will inevitably increase, with the greatest risk anticipated at the end of the 21st century (76.4%).

目的:探讨成人体检人群体质量指数(BMI)与视网膜动脉硬化的相关性,为早发现、早干预微小血管病变提供新证据.方法:采用横断面研究方法,选取2019年1—12月在武汉同济医院健康管理中心进行过眼底照相的常规体检者,收集每个样本人口学信息、体格测量指标、血生化指标及既往疾病史等特征,并对视网膜血管进行分级,采用多因素Logistic分析方法探讨BMI与视网膜动脉硬化的关系.结果:本研究纳入研究对象8678人,其中男性5378人,女性3300人,年龄为(48.6±10.4)岁.视网膜动脉硬化患病率在对照组(BMI<24.0?kg/m2)、超重组(BMI?24.0～27.9?kg/m2)、肥胖组(BMI≥28.0?kg/m2)中分别为2.0％、3.7％、6.4％,整体呈上升趋势(趋势P<0.001).在调整了年龄、性别、高血压、糖尿病、血脂异常、高尿酸血症、谷丙转氨酶、谷草转氨酶、肾小球滤过率混杂因素后,BMI与视网膜动脉硬化患病风险成正相关关系,与对照组相比,超重组和肥胖组的OR值(95％CI)分别为1.13(0.83～1.55)、1.89(1.31～2.73),趋势P<0.001;BMI每增加1?kg/m2,视网膜动脉硬化患病风险OR值为1.09(1.05～1.14).结论:超重或肥胖与视网膜动脉硬化的发生密切相关,是视网膜动脉硬化的独立危险因素.

Objective:To investigate the correlation between Helicobacter pylori ( H.pylori) infection and albuminuria inphysical examination population. Methods:It was a cross-sectional study. All the adults who received physical examination and underwent 13C-urea breath test at the Physical Examination Center in Tongji Hospital in 2021 were selected as the study subjects. General data (such as demographic information and past medical history) were documented. The physical measurement and blood biochemical indicators were checked too. Multivariate analysis was used to analyze the relationship between H. pylori infection and albuminuria. Results:A total of 30 311 subjects were included in this analysis. There were 17 123 males and 13 188 females with an age of (44.51±12.17) years. The positive rate of H. pylori infection was 27.3%. The incidence of albuminuria in subjects with H. pylori infection was 6.7%, and it was 6.1% in the subjects without H. pylori infection ( P=0.031). After adjusting for the confounding factors such as gender, age, diabetes and hypertension, H. pylori infection was independently associated with the risk of albuminuria (odds ratio ( OR)=1.133, 95% CI: 1.018-1.261, P=0.022). Conclusion:H. pylori infection is positively correlated with the occurrence of albuminuria in the physical examination population.

Objective:To investigate the relationship between liver function and arterial stiffness in the physical examination population.Methods:A total of 9 111 people who received physical examination in the Health Management Center of Wuhan Tongji Hospital from January to December 2017 with an age of 18 and above and complete clinical data were included in this study. The subjects were divided into arterial stiffness group (3 252 cases) and the normal group (5 859 cases) according to the results of brachial-ankle artery pulse wave velocity (baPWV) examination. The liver function indicators were checked in all the subjects, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and glutamyl transpeptidase γ (GGT). According to interquartile range of the liver function indicators, the subjects were divided into 4 groups (group Q1- Q4). Multivariate logistic regression analysis and restricted cubic spline functions were used to explore the relationship between liver function and risk of arterial stiffness. Results:When the subjects were grouped by ALT, after adjusted for age and gender, the risk of arterial stiffness in the Q2 to Q4 groups was 1.260 (95% CI:1.093-1.452, P<0.05), 1.571 (95% CI:1.355-1.822, P<0.001) and 2.436 (95% CI:2.097-2.830, P<0.001) times of that in the Q1 group, respectively, P for trend<0.001. And after adjusted for age, gender, body mass index, low-density lipoprotein cholesterol (LDL-C), triglycerides, high-density lipoprotein cholesterol (HDL-C), the risk of arterial stiffness in the Q2 to Q4 groups was 1.158 (95% CI:1.003-1.338, P<0.05), 1.331 (95% CI:1.143-1.551, P<0.001) and 1.867 (95% CI:1.591-2.190, P<0.001) times of that in the Q1 group, respectively, P for trend <0.001. After adjusted for age, gender, body mass index, LDL-C, triglycerides, HDL-C, systolic blood pressure, diastolic blood pressure, heart rate, fasting blood glucose, blood uric acid, serum creatinine, with or without hypertension or diabetes, the risk of arterial stiffness in the Q2 to Q4 groups was 1.116 (95% CI:0.940-1.325, P=0.210), 1.241 (95% CI:1.036-1.488, P<0.05) and 1.598 (95% CI:1.322-1.932, P<0.001) times of that in the Q1 group, respectively, P for trend <0.001. Restricted cubic spline regression analysis showed a linear positive correlation between ALT and the risk of arterial stiffness. Similar results as ALT obtained with AST, ALP and GGT. Conclusions:The increase of liver function indicators is positively correlated with the risk of arterial stiffness.

Objective:To analyse the relationship between serum electrolyte concentrations and risk of cardiovascular events in physical examination population.Methods:A cross-sectional study design was applied to survey 8 445 adults whose serum high-sensitivity cardiac tropon Ⅰ (hs-cTnⅠ) and serum electrolytes (chloride, phosphorus, calcium, sodium, potassium and magnesium) concentrations were measured at the health examination center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 1, 2018 to February 28, 2022. The risk of cardiovascular events was classified into three levels according to the serum hypersensitive cardiac troponin Ⅰ(hs-cTnⅠ) concentration: low, middle or high risk group. One-way analysis of variance was applied to compare the differences in serum electrolyte concentrations of participants with different risk levels of cardiovascular events. Ordered multi-category logistic regression was performed to analyze the correlation between serum electrolyte levels and the risk of cardiovascular events.Results:The concentration of potassium and magnesium ion in the subjects with low risk of cardiovascular events were both higher than those in the middle and high risk group [potassium ion (4.28±0.29) vs (4.24±0.34), (4.23±0.36) mmol/L, magnesium ion (0.88±0.06) vs (0.87±0.07), (0.87±0.07) mmol/L](both P<0.05), while the concentration of sodium ion was lower [(140.54±1.75) vs (140.88±1.73), (140.81±2.20) mmol/L]( P<0.001); the concentration of phosphorus ion in the high-risk group was lower than those in the middle and low risk groups [(1.04±0.17) vs (1.08±0.16), (1.05±0.15) mmol/L]( P=0.001); no significant difference was found in the concentrations of chloride and calcium ion among the three groups (both P>0.05). Compared to subjects with normal concentrations of electrolyte, the risk level of cardiovascular events in subjects with hypokalemia ( OR=6.96, 95% CI: 3.67-13.10) and hypomagnesemia ( OR=5.00, 95% CI: 1.01-24.50) was higher(both P<0.05). Within the normal range, sodium concentration was positively correlated with the risk of cardiovascular events ( OR=1.08, 95% CI: 1.03-1.14; P<0.001). Conclusions:The serum sodium, potassium and magnesium concentrations in health examination subjects are correlated with the risk of cardiovascular events. Maintaining the balanced concentration of serum potassium and magnesium, as well as low sodium levels within normal limits may help prevent cardiovascular events.

Objective Dyslipidemia is associated with an increased risk of cardiovascular disease, the major cause of death in an aging population. This study aimed to estimate the prevalence of dyslipidemia for the past decade among adults in Wuhan, China. Methods We performed a serial cross-sectional study that recruited 705 219 adults from the Health Management Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from 2010 to 2019. The diagnosis of dyslipidemia was based on the 2016 Chinese Guidelines for the Management of Dyslipidemia in Adults. Fixed effects and random effects models were applied to adjust the confounding variables (gender and age). Results The overall prevalence of dyslipidemia was 33.1% (46.2% in men and 14.7% in women) in 2019. The prevalence of dyslipidemia was significantly increased over 10 years [from 28.6% (95% CI: 28.2%–29.1%) in 2010 to 32.8 % (95% CI:32.6%–33.1%) in 2019;. P –0.001], especially for hypo-high-density lipoprotein cholesterolemia [from 18.4% (95% CI: 18.0%–18.8%) in 2010 to 24.5% (95% CI: 24.3%–24.7%) in 2019; P –0.001]. In 2019, the prevalence of dyslipidemia was higher in participants with comorbidities, including overweight/obesity, hypertension, diabetes, hyperuricemia, or chronic kidney disease, and dyslipidemia was the most significant among participants aged 30–39 years. Conclusion This study demonstrated that dyslipidemia is on the rise in men, and more emphasis should be provided for the screening of dyslipidemia in young males for the primary prevention of cardiovascular and renal diseases.

Background Urolithiasis is one of the most common diseases in urology, with a lifetime prevalence of 14% and is more prevalent in males compared to females. We designed to explore sex disparities in the Chinese population to provide evidence for prevention measures and mechanisms of stone formation. Materials and methods A total of 98232 Chinese individuals who had undergone a comprehensive examination in 2017 were included. Fully adjusted odds ratios for kidney stones were measured using restricted cubic splines. Multiple imputations was applied for missing values. Propensity score matching was utilised for sensitivity analysis. Results Among the 98232 included participants, 42762 participants (43.53%) were females and 55470 participants (56.47%) were males. Patients' factors might cast an influence on the development of kidney stone disease distinctly between the two genders. A risk factor for one gender might have no effect on the other gender. The risk for urolithiasis in females continuously rises as ageing, while for males the risk presents a trend to ascend until the age of around 53 and then descend. Conclusions Patients' factors might influence the development of kidney stones distinctly between the two genders. As age grew, the risk to develop kidney stones in females continuously ascended, while the risk in males presented a trend to ascend and then descend, which was presumably related to the weakening of the androgen signals. Key messages We found that patients' factors might cast an influence on the development of kidney stone disease distinctly between the two sexes. The association between age and urolithiasis presents distinct trends in the two sexes The results will provide evidence to explore the mechanisms underlying such differences can cast light on potential therapeutic targets and promote the development of tailored therapy strategies in prospect.

Background and AimsUrolithiasis is characterized by high rates of prevalence and recurrence. Hyperuricemia is related to various diseases. We hope to determine the association between serum uric acid (UA) level and kidney stone (KS).MethodsIn this population-based cross-sectional study, a total of 82,017 Chinese individuals who underwent a comprehensive examination in 2017 were included. The KS was diagnosed based on ultrasonography examination outcomes. Fully adjusted odds ratio (OR) for KS, and mean difference between the two groups were applied to determine the association of UA level with KS.ResultsAmong the 82,017 participants included in this study (aged 18~99 years), 9,435 participants (11.5%) are diagnosed with KS. A proportion of 56.3% of individuals is male. The mean UA level of overall participants is 341.77 μmol/L. The participants with KS report higher UA level than the participants without KS [mean UA level 369.91 vs. 338.11 μmol/L; mean difference (MD), 31.96 (95% CI, 29.61~34.28) μmol/L]. In men, the OR for KS significantly increases from 330 μmol/L UA level. Every 50 μmol/L elevation of UA level increases the risk of KS formation by about 10.7% above the UA level of 330 μmol/L in men. The subgroup analysis for male is consistent with the overall result except for the participants presenting underweight [adjusted OR, 1.035 (0.875~1.217); MD, −5.57 (−16.45~11.37)], low cholesterol [adjusted OR, 1.088 (0.938~1.261); MD, 8.18 (−7.93~24.68)] or high estimated glomerular filtration rate (eGFR) [adjusted OR, 1.044 (0.983~1.108); MD, 5.61 (−1.84~13.36)]. However, no significant association is observed in women between UA and KS either in all female participants or in female subgroups.ConclusionAmong Chinese adults, UA level is associated with KS in a dose-response manner in men but not in women. However, the association becomes considerably weak in male participants with malnutrition status.

目的 了解体质指数(BMI)正常人群多代谢异常与代谢综合征(MS)的患病情况.方法 选取2016年1月-2017年12月健康体检人群为研究对象,以2004年中华医学会糖尿病学分会制订的MS诊断标准,符合纳入标准的正常BMI对象共5 781名(男3069名,女2712名).根据BMI的四分位数将调查对象分成Q1～Q4组计算性别、年龄别MS的患病率.结果 5 781名对象的MS患病率为12.71％(男性9.22％,女性16.67％,X2= 71.92,P＜0.001).专业技术人员的MS患病率较其它职业人群显著增高(x2 = 19.76,P= 0.001),低学历人群的MS患病率较高学历人群显著增高(x2 =10.79,P= 0.005).男性随BMI 升高(Q1～Q4)MS 患病率由3.21％增至17.54％(x2 = 87.11,P＜0.001);女性(Q1～Q4)MS患病率由7.32％增至29.78％(x2= 147.66,P＜O.001).男性各个BMI组MS患病率均低于女性(Q1:3.21％vs 7.32％,x2=10.31,P＜0.001;Q2:6.35％vs 10.26％,x2= 8.64,P＜O.001;Q3:9.72％vs 19.27％,x2 = 27.39,P＜O.001;Q4:17.54％vs 29.79％,x2 = 28.11,P＜0.001).男性随年龄升高(≤40岁～≥60岁)MS 患病率由3.43％增至13.15％(x2 = 67.09,P＜0.001)、女性(≤40岁～≥60岁)MS 患病率由10.72％增至24.25％(x2 = 54.43,P＜0.001);随BMI 升高(Q1～Q4),伴有MS组分异常的患病率由28.51％增至40.56％(x2 = 77.39,P＜0.001).结论 BMI正常人群仍有一定多代谢异常和MS患病率,要注意BMI正常人群的代谢性健康风险管理.

Background & aims: The association between serum 25-hydroxyvitamin D [25(OH)D] and type 2 diabetes mellitus (T2DM) remains inconclusive. Moreover, whether inflammatory biomarkers are involved in this association has not been explored. This study aims to investigate serum 25(OH)D in relation to T2DM in a Chinese population and provide clues for the inflammatory mechanism whereby serum 25(OH)D deficiency increases T2DM risk. Methods: A cross-sectional study of 47,803 participants aged 18-96 years was performed in a health management center in 2017. Multivariate linear or logistic regression models and mediation analysis were used to examine the relationships between serum 25(OH)D, inflammatory biomarkers (white blood cell counts and mean platelet volume), and T2DM. Results: Of the 47,803 participants included, 5.2% were diabetic and 51.4% were serum 25(OH)D deficient. The study revealed a significant inverse association between serum 25(OH)D and T2DM risk after adjustment for potential confounders (P for trend 1/4 0.002); the multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) across serum 25(OH)D levels (sufficiency, insufficiency, and deficiency) were 1.00 (reference), 1.17 (1.03-1.33), and 1.25 (1.09-1.43), respectively. This study also showed a significant indirect effect of serum 25(OH)D on T2DM risk through total white blood cell count, neutrophil count, lymphocyte count, and monocyte count (P values < 0.05); the proportions mediated were 9.89%, 7.51%, 2.94%, and 2.82%, respectively. Conclusions: Serum 25(OH)D deficiency was independently associated with an elevated risk of T2DM in a Chinese adult population and low-grade systemic inflammation might be one of its biological mechanisms. (C)& nbsp;2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Objectives Hyperuricaemia is a risk factor for gout attacks, kidney damage and cardiovascular events. Evidence on the trends in hyperuricaemia burden in Wuhan city, China, was limited. The present study aimed to estimate the prevalence of and a decade trend in hyperuricaemia in Wuhan city.Design Cross-sectional study.Setting Health Management Center of Tongji Hospital.Participants A total of 732 527 adult participants from the general population who took a physical examination in the Health Management Center between 2010 and 2019.Main outcome measures Prevalence of and trends in hyperuricaemia.Results The overall prevalence of hyperuricaemia was 25.8% (36.6% in men and 10.8% in women) in 2019. The hyperuricaemia prevalence and serum uric acid (SUA) levels were significantly higher in young men, old women and participants with obesity, hypertension, diabetes or dyslipidaemia (p<0.05). SUA levels among men and women gradually increased from 358.0 (313.0–407.0) umol/L and 250.0 (217.0–288.0) umol/L in 2010 to 388.0 (338.0–445.2) umol/L and 270.0 (233.0–314.0) umol/L in 2019, respectively, p<0.05. From 2010 through 2019, hyperuricaemia prevalence significantly increased in each age category and it increased most sharply among participants aged 20–39 years. The multivariate-adjusted prevalence among men was 26.1% (25.4% to 26.7%) in 2010, 30.9% (30.4% to 31.4%) in 2015 and 34.4% (34.1% to 34.8%) in 2019, while among women it was 5.8% (5.4% to 6.2%) in 2010, 7.2% (6.9% to 7.5%) in 2015 and 10.1% (9.9% to 10.3%) in 2019.Conclusions Hyperuricaemia was highly prevalent among adults in Wuhan city. More attention should be paid to the increasing burden of hyperuricaemia, especially for those at higher risks.

This cross-sectional study examines the seropositive prevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, by sex and age group.

AbstractAims/IntroductionSeveral epidemiological studies investigated the effect of Helicobacter pylori infection on diabetes, but the conclusions remained inconsistent. We aimed to explore the relationship between H. pylori infection and diabetes, as well as glycemic metabolism profiles.Materials and MethodsA cross‐sectional study including 58,482 Chinese adults was carried out between January 2016 and December 2017. H. pylori infection was diagnosed by the 13C‐urea breath test. Multivariate regression analyses were carried out to evaluate the association of H. pylori infection with diabetes.ResultsOf the 58,482 participants, 3,449 (5.9%) had diabetes. The H. pylori‐positive participants had a higher rate of diabetes (7.3% vs 5.2%, P < 0.001), and higher levels of fasting plasma glucose (5.36 ± 1.12 mmol/L vs 5.28 ± 0.95 mmol/L, P < 0.001) and glycated hemoglobin A1c (5.63 ± 0.68% vs 5.57 ± 0.60%, P < 0.001) than the H. pylori negative group. Multivariate regression analyses showed that H. pylori infection was positively related to diabetes (odds ratio 1.25, 95% confidence interval 1.15–1.35). Among the H. pylori‐positive participants, the elevated levels of fasting plasma glucose and glycated hemoglobin A1c were 0.033 mmol/L (95% confidence interval 0.016–0.049 mmol/L) and 0.024% (95% confidence interval 0.008–0.041%), respectively. Additionally, H. pylori infection was significantly related to diabetes in participants aged ≥44 years, but not in participants aged <44 years.ConclusionsThe present study showed that H. pylori infection is associated with diabetes among Chinese adults. More attention should be paid to adults with H. pylori infection for effective prevention of diabetes.

Objective To explore the association between Helicobacter pylori (H. pylori) infection and overweight/obesity in a Chinese population. Methods This was a cross-sectional study that included all adult participants who underwent a 13C-urea breath test at the physical examination center in Tongji Hospital (Wuhan, China) in 2016. Data on demographic characteristics, anthropometric index, biochemical variables, and medical history were collected. Multivariate analyses were performed to assess the relationship between H. pylori infection and overweight/obesity, as well as body mass index (BMI). Results Of the 27 883 participants included, 17 585 were males and 10 298 were females. They were aged (43.94±11.31) years. The prevalence rate of H. pylori infection was 33.1%. The BMIs of subjects with and without H. pylori infection were (24.30±3.28) kg/m2 and (23.99±3.35) kg/m2, respectively (t=-7.28, P<0.001). After adjusting for age, sex, blood lipid levels, diabetes, and hypertension, the BMI of subjects with H. pylori infection was 0.120 kg/m2 (95% CI: 0.050-0.191, P=0.001), which was higher than that of subjects without H. pylori infection. Moreover, H. pylori infection was independently associated with a higher risk of prevalent overweight/obesity, with an odds ratio (OR) of 1.09 (95%CI: 1.03-1.16, P=0.004). The positive association between H. pylori infection and overweight/obesity was more evident among women, with an OR of 1.19 (95%CI: 1.07-1.31, P=0.001). Conclusion H. pylori infection was closely correlated with overweight/obesity. Control of H. pylori infection may be useful in reducing the heavy disease burden caused by overweight/obesity. Key words: Helicobacter pylori; Overweight; Obesity

Background: The aldosterone/renin ratio (ARR) is recommended to screen for primary aldosteronism (PA) in hypertension. We estimated fully automated chemiluminescence immunoassays (CLIA) for plasma aldosterone concentrations (PAC) and plasma direct renin concentrations (PRC) and investigated their reference intervals in Chinese Han population. Methods: PAC and PRC were measured on a fully automated analyzer (LIAISON XL, DiaSorin, Italy). Performance characteristics were estimated according to CLSI approved guidelines. 328 healthy individuals were selected for reference intervals investigation. Results simultaneously tested by CLIA and radioimmunoassays were reviewed from 123 patients with hypertension and/or adrenal space-occupying lesion. PAC/PRC ratio (ARR(prc)) was compared to PAC/plasma renin activity (PRA) ratio (ARR(pra)). Results: Within-laboratory imprecision was 5.6%-6.7% for PAC and 3.0%-3.3% for PRC. The LoQ was 72.2 pmol/L for PAC and 1.27 mIU/L for PRC. Linearity was excellent in the range of concentrations between 94 and 2708 pmol/L for PAC and 1.3-461.8 mIU/L for PRC. Interferences of hemoglobin, unconjugated bilirubin and lipaemia could be acceptable, but not of conjugated-bilirubin when renin and aldosterone at low concentrations. The central 95% reference intervals for males: PAC: 76-722 pmol/L, PRC: 3.3-92.7 mIU/L, ARR: 2.2-46.0 pmol/mIU; for females: PAC: 85-1010 pmol/L, PRC: 3.7-99.8 mIU/L, ARR: 3.6-68.4 pmol/mIU. Upper reference limits for ARR of younger and older men were lower than women. ARR(prc) and ARR(pra) showed almost perfect agreement (kappa=0.815) for screening PA. Conclusion: The DiaSorin tests are valuable analytical options for PAC and PRC measurements. We recommend sex-specific and age-specific reference intervals of these items should be estimated.

目的 探讨不同年龄、性别及不同季节健康成年人群的维生素D(VD)营养状况.方法 选取2016年1月1日～12月31日于我院体检中心完成体格检查且肝肾功能正常的健康成人9997例,检测其血清25-羟维生素D3[25(OH)D3]浓度.分别定义血清25(OH)D3≥30 ng/ml、20～30 ng/ml与≤20 ng/ml为VD正常、不足与缺乏.将年龄≤44岁、45～59岁、≥60岁分别定义为青年、中年及老年.所有研究对象根据性别及年龄进行分组,分别统计各组血清25(OH)D3浓度及VD正常、不足、缺乏者的百分比并进行比较.按月份分别统计VD正常、不足及缺乏的例数.结果 总体人群、男性组及女性组VD正常者所占百分比分别为18.3％、23.8％及10.1％,VD不足者分别为38.5％、40.9％及34.8％,VD缺乏者分别为43.2％、35.3％及55.1％;男性组VD缺乏和不足的整体占比低于女性组(P<0.001).青年、中年和老年组VD不足者所占百分比分别为37.0％、40.0％及40.0％,VD缺乏者分别为45.0％、42.1％及36.6％;青、中年VD缺乏及不足的整体占比高于老年人群(P<0.001).男性组血清25(OH)D3浓度为(24.15±8.77)ng/ml,明显高于女性组[(20.06±7.55)ng/ml,P<0.001].青年组、中年组、老年组的血清25(OH)D3浓度分别为(22.31±8.54)ng/ml、(22.49±8.32)ng/ml、(24.00±9.56)ng/ml,老年组血清25(OH)D3浓度高于青年组及中年组(P<0.001).VD缺乏率2月最高(75.9％),10月最低(26.9％).结论 VD不足和缺乏在健康成年人群中较普遍,尤其在≤44岁人群及女性中;而2月份VD缺乏更加严重.

目的 调查2014年武汉地区无症状体检人群贫血的发生情况,为贫血的早期防治提供依据.方法 收集2014年在我院进行健康体检的成人52 657例,根据性别和年龄(≤29岁、30 ～ 39岁、40 ～ 49岁、50 ～ 59岁、60 ～ 69岁和≥70岁)对其进行分组,比较分析其血常规参数.结果 52657例体检者中,贫血检出率为1.37％ (724/52657),其中男性为0.38％(113/30105),女性为2.70％ (611/22552).男性贫血检出率随年龄增加而升高,≥70岁人群明显升高;＜50岁女性贫血检出率随年龄增加而升高,50 ～ 69岁检出率下降,≥70岁人群检出率再次升高.贫血类型总体以小细胞低色素贫血为主,占44.89％ (325/724);女性患者中,小细胞低色素贫血占47.79％(292/611),＜60岁患者以小细胞低色素性贫血为主,≥60岁患者以正细胞性贫血和大细胞性贫血为主;男性患者中,正细胞性贫血占46.02％(52/113),而在＜60岁患者中以小细胞低色素性贫血为主.结论 2014年武汉地区体检人群贫血检出率与年龄及性别相关.女性及老年人群的贫血检出率较高,特别是＜50岁女性及≥70岁人群.应加强健康教育,定期监测血常规,以早期发现贫血并及时诊治.

Epidemiological studies demonstrated that Helicobacter pylori (H. pylori) infection was associated with cardiovascular disease and its risk factors. However, the association between H. pylori infection and hypertension remained unclear. The aim of this study was to investigate the association between H. pylori infection and prevalence of hypertension among Chinese adults. We performed a cross-sectional study of 5246 adult participants who were recruited from a health manage center. All participants underwent a 13C-urea breath test and a routine health check-up. Logistic and liner regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for hypertension in relation to H. pylori infection. Of the 5168 study participants aged 18–70 years, 2034 (39.4%) were females and 955 (18.5%) had hypertension. After adjustment for potential confounders, H. pylori infection was associated with an increased prevalence of hypertension (OR, 1.23; 95% CI, 1.04, 1.46). In addition, compared with participants not infected with H. pylori, those with H. pylori infection had an increase of 0.735 mmHg (95% CI, 0.101, 1.369) for diastolic blood pressure and 0.723 mmHg (95% CI, 0.034, 1.413) for mean arterial pressure. There was no significant interaction between H. pylori infection and age, sex, and body mass index on the prevalence of hypertension (all P values for interaction >0.05). Findings from this study demonstrate that H. pylori infection was positively associated with prevalence of hypertension among Chinese adults. More well-designed studies are warranted to confirm our findings.

目的 探讨抗髓过氧化物酶中性粒细胞胞质抗体(myeloperoxidase-antineutrophil cytoplasmic antibody,MPO-ANCA)相关性肥厚性硬脑膜炎的临床特点.方法 报告华中科技大学同济医学院附属同济医院风湿免疫科收治的1例MPO-ANCA相关性肥厚性脑膜炎病例,根据其临床特点及诊疗经过,结合相关文献进行回顾性分析.结果 患者为56岁妇女,主诉间断性头痛、发热以及双腿肌肉疼痛,且MPO-ANCA阳性.磁共振成像显示硬脑膜弥漫性增厚伴脑白质缺血.脑磁共振血管造影显示血流于大脑中动脉起始区中断,且两侧大脑前动脉近端狭窄.患者的主要症状在静脉注射糖皮质激素和环磷酰胺后得以改善.该病例在病程中出现轻度肾功能不全及肺间质性病变.MPO-ANCA相关性血管炎是肥厚性硬脑膜炎的主要病因之一,本文复习了MPO-ANCA相关性肥厚性硬脑膜炎的相关文献,发现MPO-ANCA相关性肥厚性硬脑膜炎患者合并脑血管病变、肾损伤及间质性肺病的比例较高.结论 MPO-ANCA相关性肥厚性硬脑膜炎是一种罕见疾病,主要发病于年长女性,头痛为首发症状,临床医生应注意其他器官及系统受累的发生.