Objective To analyze clinical common pathogenic bacteria distribution of neonatal sepsis and antimicrobial resistance ,in order to provide theoretical basis for clinical rational use of antibiotics .Methods 342 cases of neonatal sepsis were selected as the research objects ,through the case control study ,specimens were collected retro-spectively the clinical data and blood culture ,to understand the pathogenic bacteria children with neonatal septicemia culture,To understand the pathogenic bacteria in children with neonatal septicemia culture .Distribution and drug resistance of pathogenic bacteria were analyzed .Results 342 cases of neonatal septicemia infection rate was 5.4%, among the 136 cases of preterm infants with sepsis ,infection rate is 10.9%,206 cases of full-term infants with sep-sis,infection rate was 4.0%, Septicemia in premature infants infection than full -term sepsis (χ2 =88.07, P <0.01);No significant difference of septicemia in premature infants and full -term infants septicemia pathogen strain distribution(P>0.05).Coagulase negative Staphylococcus aureus and Staphylococcus aureus resistant to penicillin , drug resistance rates were 97.1% and 87.5%,secondly to erythromycin resistance ,respectively were 86.9% and 75.0%;Three kinds of common gram negative bacteria were sensitive toimipenem ,resistance to ampicillin and cefazo-lin,drug resistance rate was 100.0%,the second was piperacillin ,cefepime,cefotaxime and ceftazidime .Conclusion Neonatal septicemia of gram positive bacteria mainly coagulase negative Staphylococcus aureus and Staphylococcus aureus,gram negative bacteria mainly in grams of Klebsiella pneumoniae , Escherichia coli and Escherichia coli . Common pathogenic bacteria with drug resistance .Clinical treatment of neonatal sepsis should be rational use of anti -biotics,to strengthen the monitoring of drug resistance .

<正>手足口病(hand-foot-and-mouth disease,HFMD)是儿童尤其是婴幼儿常见传染病之一,主要由肠道病毒尤其以EV71及CoxA16感染最为常见。HFMD患儿的临床经过及转归差别较大,与患儿机体免疫状况可能存在一定关系。本研究对我院2012年4月—10月收治的112例EV71阳性、53例CoxA16