Background: Radix Scutellariae (RS) has been used to treat influenza for thousands of years in China. However, its mechanisms of action remain unclear. The aim of the present study was to use a network pharmacology and molecular docking-based approach to explore active components and potential molecular mechanisms of RS for influenza A. Methods: Target genes of RS and influenza A were attained by accessing network databases. We then determined the intersection of both genes through bioinformatics using R and Perl language. The protein protein interaction (PPI) network was constructed by the STRING website (https://cn.string-db.org). The network analysis was done using Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were applied for the above genes. Effective components as core targets were screened out based on the condition that the interaction must come first. These core targets were combined with 3D structures of main RNA coding proteins of influenza A virus. Molecular docking was used to visualize drug-target interaction via AutoDock Vina and PyMOL. Results: Twenty-eight active components and 40 target genes were acquired through the regulatory network of active components of RS and the PPI network. Seventy-one bioinformatics expressions were obtained through GO enrichment analysis (P<0.05). A total of 124 signaling pathways were screened by KEGG enrichment analysis (P<0.05). Acacetin, wogonin, baicalein, oroxylin A, and beta-sitosterol, which are rich in RS, are closely related to hemagglutinin (HA), NeurAminidase (NA), nucleoprotein (NP), polymerase basic protein 1 (PB1), polymerase basic protein 2 (PB2), polymerase acidic (PA), matrix protein 1 (M1), matrix protein 2 (M2), and non-structural protein (NS), which are the main RNA coding proteins of influenza A virus. The binding energies of these 8 proteins were less than -5 kJ/mol, indicating that the ligands had strong affinity with receptor proteins. Conclusions: RS is rich in core target compounds, and its mechanism of action is further expressed. It could have a good therapeutic effect for influenza A through multi-compound and multi-target regulation of these specific protein targets, and targets and pathways related to immunity and inflammation.

目的：观察中药疣毒净制剂治疗宫颈高危型人乳头瘤病毒（HR－HPV）感染的临床疗效及护理方法。方法：将2014年1月至2015年12月广东省中医院大学城医院门诊诊治的宫颈HR－HPV 感染患者40例随机分成治疗组和对照组各20例；治疗组用中药疣毒净制剂外用，对照组用生理盐水外用，每周治疗3次，治疗3个月共19次，于第3次月经干净后复查，观察HR－HPV 转阴率及药物的不良反应。结果：治疗组HR－HPV 的病毒清除率明显高于对照组（55％ vs 20％，P＜0．01），两组均未见不良反应。结论：外用疣毒净制剂对 HR－HPV 感染宫颈病变有较好的治疗效果，且无毒副作用，建议临床推广应用。

Objective:To investigate the efficacy of balance acupuncture combined with oblique-pulling manipulation in lumbar disc herniation. Meth-ods:72 cases of patients were all treated by balance acupuncture combined with oblique-pulling manipulation. Results:55 cases were cured, 9 cases were markedly effective, 6 cases were effective, and 2 cases were ineffective, the total effective rate was 97.2%. Conclusion:It has a good efficacy to treat lumbar disc herniation with balance acupuncture combined with oblique-pulling manipulation.

运动疗法是运动在医学中的应用,它对神经系统、心血管系统、呼吸系统、骨关节系统等均有良好的康复作用,是康复治疗的重要手段[1].人工膝关节置换(TKA)于上世纪70年代应用于临床,其目的在于缓解膝关节疼痛,矫正膝关节畸形.改善患膝关节功能状态,从而提高患者的生活质量[2],主要用于各种原因引起的膝部骨关节炎患者.2002-2006年,本院骨二科对46例患者施行人工全膝关节置换手术,术后施行运动疗法护理.现将护理经验总结如下.