目的：探讨血清α2-巨球蛋白（α2-MG ）在评估2型糖尿病肾病中的应用价值。方法空腹采集血样，其中确诊的2型糖尿病肾病者46例，2型糖尿病无肾病者73例，同期健康对照者66例，用免疫比浊检测血清α2-MG、尿微量清蛋白水平，用高效液相色谱法检测糖化血红蛋白（HbA1c）水平，并进行组间比较，分析糖尿病肾病患者血清α2-MG 与尿微量清蛋白和 HbA1c 的相关性。结果血清α2-MG、尿微量清蛋白在糖尿病肾病者分别为（2．25±0．53）g／L 和（199．8±100．9）mg／L，明显高于健康对照者和糖尿病无肾病者，差异有统计学意义（P ＜0．05）；糖尿病肾病者中血清α2-MG 水平与尿微量清蛋白呈显著正相关（r ＝0．514，P ＜0．05）。结论检测血清α2-MG 水平对诊断、预测糖尿病肾脏损伤具有重要的应用价值。

近年来,缺氧缺血性脑病(hypoxic-ischemic encephalopath,HIE)在新生儿中发病率较高,是造成新生儿早期死亡及致残的重要原因之一.国内外采用高压氧(hyperbaric oxygen,HBO)治疗新生儿HIE取得了较好疗效,对其进行早期干预可以有效减少后遗症的发生,而传统的常规药物治疗效果并不理想.我院对48例HIE患儿实施HBO治疗取得较好的临床效果.现报道如下.

Objective To analyze significance of the differential diagnosis of hepatic carcinoma and detect Alpha-fetopreteins heterogeneity(AFP-L3) using microspincolumn coupled with lens culinaris agglutinin.Methods The Serum Samples were collected from 170 patients with AFP positive diagnosed with benign and malignant liner diseases.AFP-L3 was separated by using microspincolumn.The levels of AFP and AFP-L3 were determined by electro-chemiluminesent method and the ratio of AFP-L3 and AFP was calculated.Results AFP-L3>10% was taken as a diagnoatic indicator.The levels of AFP-L3 in 75 cases with hepectic carcinoma increase significantly compared with 95 cases of kenign liver diseases(P<0.01).Conclusion The detection of AFP-L3 using microspincolumn has the important significance of the differential diagnosis of hepatic carcinoma and benign liver diseases.

Objective To research autoantibody generation condition in body after treponema pallidum infection,and to discuss the complex and changeable possible causes of syphilis in the clinical.Methods The research objects were syphilis patients who were confirmed by TPPA.Nonspecific Tp antibody and ANA were dedected in serum of syphilis patients with toluidine red unheated-serum test(TRUST) and indirect immunofluorescence test,.Significance of ANA positive rate in syphilis patients were statisticed with chi-square test.Results Compared with normal control group,the ANA positive rate(44.8%) in syphilis patients was significant difference,P<0.01.the ANA positive rate(31.3%) in syphilis patients who were positive in TRUST was higher significantly than patients who were negative in TRUST(13.5%,P<0.05) and normal control group(16.2%,P<0.01);But ANA positive rate was no statistically significant difference,compared normal control group,P=0.645.Conclusion Aotoantibodies produced significantly higher than normal control group in syphilis patients serum,the complex and changeable causes in the clinical maybe relevant with autoantibody generation of syphilis patients.