目的：探讨C-erb B-2、p53、Ki-67及ER、PR在不同子宫内膜组织中的表达及其与子宫内膜癌发生、发展之间的关系。方法：对30例正常内膜（A组）、30例不典型增生（B组）、85例子宫内膜癌（C组）手术标本进行病理检查,采用免疫组化法进行标记。结果：C-erbB-2、p53在A、B、C组中阳性表达率逐渐升高,组间比较差异均有显著性（P〈0.05）;Ki-67在C组中的阳性表达率明显高于A组和B组（P〈0.05）;C-erbB-2、p53及Ki-67的阳性表达率随病理分期、组织学分级及脉管癌栓或淋巴结转移率的升高而升高（P〈0.05）;ER、PR在A、B及C组中表达率呈下降趋势,且随组织学分级及肌层浸润深度的增加而下降（P〈0.05）;C组中ER与PR的表达及C-erbB-2与Ki-67的表达均呈正相关,C-erb B-2与ER的表达呈负相关。结论：联合检测C-erbB-2、p53、Ki-67及ER、PR在子宫内膜癌中的表达可作为早期诊断、指导内分泌治疗及判断预后的重要指标。
<正>患者女,26岁,因"右下腹痛3d余,再发5h"拟"1、右下腹痛查因:阑尾炎?2、孕15周,宫内活胎"于2011年4月2日入院。患者平素月经规则,月经周期28～30d,经期4～5d。体检:腹平坦,下腹肌稍紧,右下腹压痛(+),反跳痛(+);妇检:外阴:阴毛浓密,小阴唇略小;阴道宫颈未检;宫底高度脐耻之间,腹围76cm,胎心率146次/min。
OBJECTIVE:To explore changes of serum adiponectin and insulin resistance in patients with endometrial cancer and to evaluate the clinical significance and correlation. METHODS:The serum levels of adiponectin and fasting insulin were determined by ELISA, electro-chemilluminometry and radioimmunoassay in 35 patients with endometrial cancer [all patients divided into two groups, A1 group belonged to without postmenopausal when first visiting (n = 20), A2 group belonged to postmenopausal when first visiting (n = 15)] and 30 cases of health control. The result of homeostasis model assessment-insulin resistance (HOMA-IR) index was calculated. RESULTS:The levels of adiponectin in A1 group was lower than that of health control group [(6.7 ± 1.1) versus (10.0 ± 1.4) ng/L, P < 0.05], and HOMA-IR was higher than that of health control group (3.5 ± 1.8 versus 1.1 ± 0.7, P < 0.05). While there were not significant difference between A2 group and health control group (P > 0.05). Adiponectin and insulin resistance was negatively correlated (r = -0.389, P < 0.05). CONCLUSION:Adiponectin reducing and insulin resistance in reproductive age patients may be the independent factors to promote endometrial cancers.
<正>子宫内膜癌为女性生殖道常见三大恶性肿瘤之一,发病危险因素与内外源性雌激素、月经史、生育史、生活方式等有关[1]。肥胖、2型糖尿病、高血压被视为子宫内膜癌三联征。脂联素是脂肪细胞分泌的一种细胞因子,与肥胖、2型糖尿病、高血压等密切相关[2]。脂联素可通过影响细胞信号转导通路从而抑制子宫内膜癌细胞增殖,促进凋亡。2型糖尿病本身可增加妇科恶性肿瘤的发病危险。恶性肿瘤治疗过程中由于化疗药物的使用可产生胰岛素抵抗,继发2型糖尿病。现对脂联素、2型糖尿病与子宫内膜癌相关性作一
