目的:观察小蓟饮子治疗慢性肾小球肾炎血尿的临床疗效。方法:27例给予小蓟饮子口服治疗8周。结果:治疗前尿红细胞数(44.110±37.102)/UL,治疗8周后减少为(23.700±27.761)/UL。临床控制5例,显效13例,无效9例,总有效率66.7%。未见不良反应。结论:小蓟饮子治疗慢性肾小球肾炎血尿有一定疗效。
目的研究清热益气化淤通络治疗糖尿病肾病(DN)蛋白尿作用机制。方法将Wistar大鼠随机分为正常对照组(C)和糖尿病肾病造模组(予腹腔内注射链脲佐菌素制备糖尿病肾病模型)。将造模成功的大鼠再分为模型对照组(M)、中药观察组(T)和厄贝沙坦组对照组(I)。分别检测各组:①血糖、血肌酐、24 h尿蛋白定量等;②肾脏病理、电镜以及免疫组化分析;③实时定量RT-PCR分析。结果①成模大鼠符合DN 1级病变;T和I干预下基底膜增厚减轻(P<0.05);②与M和I相比较,T尿蛋白定量明显减少(P<0.05);③与M比较,T和I的nephrin和podocin表达损害明显减轻(P<0.05);④与M比较,T和I的nephrin和podocin mRNA表达损害明显减轻(P<0.05)。结论该中药可拮抗DN大鼠的足细胞损害;减少其尿蛋白。
Objective To evaluate the effect and safety of integrative traditional Chinese medicine and western medicine therapy for chronic renal failure.Methods Electronic and manual searches were conducted to identify randomised controlled trails(RCTs) in last 15 years for treating chronic renal failure with integrative traditional Chinese medicine and western medicine and the data was analysed by revman 5.0.Results 23 Chinese RCT studies were invollved.According to the statistical data,the method of integrative traditional Chinese medicine and western medicine could slow down the speed of serum reatinine increase and delay the time of serum reatinine double increase.Conclusion The method of integrative traditional Chinese medicine and western medicine could slow down the progress of chronic renal failure more effectively.
The article is summarizing TCM clinic research of hematuria of chronic glomerulonephritis in lately decade,including pathogeny,pathogenesis and treatment,prescription of chronic GN.This disease usually caused by heat damaged the collateral,viscera (liver,spleen or kidney) qi and yin deficiency couldn't control the blood and blood spilled the vein or blood stasis which caused by qi deficiency couldn't move the blood.Syndrome differenciation,classical prescription were commonly used in traditional chinese medicine treatment with certain effect,such as the way of nourishing yin and clearing heat、cooling blood and hemostasis,Reinforcing spleen and kidney,tonifying qi andyin,promoting blood circulation for removing blood stasis,and on the base of previous experience,a part of Chinese patent drug and yraditional Chinese medicine injections also had obvious clinical effect.
