This study aimed to investigate the survival and influence factors of radiation therapy on primary tumors in patients with stage IVB cervical cancer. The data of 3129 stage IVB cervical cancer patients diagnosed from 2000 to 2018 in the Surveillance, Epidemiology and End Results (SEER) database were retrieved, and the propensity score matching (PSM) was used to balance variate and eliminate selection bias. The Kaplan-Meier (K-M) method was used to plot surviving profile. Univariate and multivariate analyses were used to estimate influencing factors of surviving time of stage IVB cervical cancer. After screening the SEER database, 3129 stage IVB cervical cancer patients were selected, including 2166 cases (69.2%) cases with and 963 without primary radiotherapy. PSM analysis identified 860 pairs of patients were one-to-one matched and further enrolled of radiotherapy part as well as non-radiotherapy part (control group) respectively for survival analysis. The K-M curve was compared among the two groups, and radiation therapy was found to be associated with longer survival before (Hazard ratio (HR) = 0.54,95% confidence interval (95% CI): 0.50-0.59, p < 0.001) and after (HR = 0.71, 95% CI: 0.64-0.79, p < 0.001) PSM. Multivariate Cox analysis confirmed that patients treated with radiotherapy, chemotherapy and local surgery had greater survival benefits, while high-grade tumor lesions, bone metastases, liver metastases and lung metastases were associated with significantly increased mortality. The survival rates varied among different races and were statistically different (p < 0.05). Conclusion: Primary radiotherapy could prolong the overall survival (OS) of stage IVB cervical cancer patients.

目的 评估总胆红素与直接胆红素及二者的比值对广泛期小细胞肺癌(ES-SCLC)患者预后的预测价值.方法 选取中国人民解放军联勤保障部队第九○一医院2018年1月至2020年7月收治的83例ES-SCLC患者为研究对象.收集患者入院时临床资料、生化检验、无进展生存期(PFS)和总生存期(OS)等.采用多因素Cox回归分析胆红素对ES-SCLC患者生存预后的影响,用Kaplan-Meier方法评估生存时间.结果 总胆红素和总胆红素/直接胆红素对ES-SCLC患者生存预后具有预测价值(P<0.05),最佳截断值分别是12.3μmol/L和2.8;与低总胆红素组(≤12.3μmol/L)患者比较,高总胆红素组(>12.3μmol/L)患者有更长的中位PFS和OS(P<0.05);与低总胆红素/直接胆红素组(≤2.8)患者比较,高总胆红素/直接胆红素组(>2.8)患者有更长的中位PFS和OS(P<0.05);总胆红素和总胆红素/直接胆红素是影响ES-SCLC患者独立预后因素(P<0.05).结论 总胆红素水平和总胆红素/直接胆红素水平可能是ES-SCLC的重要预后因素,有助于判断患者的预后.

上皮-肌上皮癌又称腺肌上皮瘤,透明细胞腺瘤;透明细胞癌;恶性肌上皮瘤;管状实性腺瘤等,是一种低度恶性肿瘤,发病率很低,老年男性多发,主要发生于大小涎腺,80％发生于腮腺,小涎腺发生率在1％ -2％ [1] ,支气管的上皮-肌上皮癌发生率更低,原发于支气管的上皮-肌上皮癌发源于支气管黏膜下层腺体,大部分起源于大支气管内,多数有气道阻塞症状,支气管的上皮-肌上皮癌国内外少有报道. 现将我科收治的1例气管上皮-上皮癌治疗报道如下,探讨其发病情况、病理特征及免疫组化特点、临床表现、诊断及鉴别诊断、治疗及预后.

<正>横纹肌肉瘤(rhabdomyosarcoma,RMS)是儿童和青少年最常见的软组织肿瘤,但在成人中少见,且腺泡状横纹肌肉瘤(alveolar rhabdomyosarcoma,ARMS)更是多见于青少年。现将本院收治的1例全身多发性ARMS的临床表现、病理特征及治疗效果报告如下。1病案摘要患者女性,19岁。2010年12月发现背部及左乳皮下包