目的:探讨潮湿环境因素对正常及脾阳虚大鼠一般情况的影响,为建立内外合邪动物模型做初步尝试.方法:选取40只SD大鼠随机分为对照组、脾阳虚组、外湿组、脾阳虚加湿组,每组10只.脾阳虚组模型制作采用番泻叶灌胃,皮下注射利血平与强迫大鼠游泳交替进行的复合方法.造模后,给予外湿组与脾阳虚加湿组潮湿环境1周,于造模前后观察并记录各组大鼠的体质量、进食量、饮水量、精神活动、皮毛光泽度及大便性状并进行宏观症候评分.结果:造模后,脾阳虚加湿组大鼠体质量显著减轻,较其余3组显著降低(P＜0.01,P＜0.05).脾阳虚加湿组大鼠在进食、饮水、精神状态、毛色、大便性状等方面较其余3组发生了一定的变化.宏观症候评分较脾阳虚组显著降低(P＜0.01).结论:潮湿环境因素对正常及脾阳虚大鼠的一般情况都有影响,对脾阳虚大鼠影响更为明显.

脾为后天之本,气血生化之源,运化水谷精微及水液.湿邪为六淫邪气之一,湿为阴邪,易伤阳气,侵袭人体,无处不到.脾为阴土,喜燥而恶湿,对湿邪有特殊的易感性.湿邪外袭则湿困脾,湿为阴邪,易损伤脾阳,而阳虚者易感湿邪,湿浊留滞即可损伤脾阳,脾阳受伐,又可滋生内湿.湿邪外袭与湿自内生内外合邪互为因果.

Objective To investigate the effect of external humidity environment factors on the pro-liferation of spleen cells in normal and spleen deficiency rats,and to study the pathogenesis of internal and external pathogenic mechanisms of the compound. Methods Forty SD rats were randomly divided into the control group,the wet group,the spleen yang deficiency group,and the Spleen Yang humidification group. There were 10 rats in each group. The spleen was successfully removed after the model was successfully made,and the spleen lymphocyte proliferation was induced by ConA,so as to express the function of the lym-phocyte. Results The spleen lymphocyte proliferation ability of spleen deficiency group,external dampness group and spleen yang humidification group were significantly lower than that of the control group( P ﹤0. 01). The spleen lymphocyte proliferation ability of spleen deficiency and spleen deficiency humidification group were significantly decreased( P ﹤ 0. 01). Conclusion The external humidity environment factor is stronger than the spleen yang deficiency factor to the immune suppression effect of organism. Wet environment factors shows more obvious immunological effect in normal rats and spleen yang deficiency model rats than simple spleen yang deficiency model rats. And wet environment factors and spleen yang deficiency model have collaborative induced decline effect in immune function.

哮喘是内科临床上的常见病和多发病之一,随着哮喘发病率的逐年增加,许多临床学者积极致力于中医药防治本病的研究,取得了较好的疗效,对近年来中医药治疗哮喘进行综述。指出现阶段中医药防治哮喘取得的成就以及目前需解决的问题:药物作用机制尚未认识清楚,尚无公认的、快速控制哮喘急性发作和显著预防哮喘复发的中药制剂。

中国是最早重视和研究地域、气候与疾病关系的国家。《内经》指出"人与天地相参",人体生理病理变化与自然气候密切相关。对近10年100余篇地域、四季气候与疾病相关性的文献整理研究,发现地域及四季气候与疾病发生密切相关,该领域研究对临床防病治病有着重要的指导意义。

《内经》对五脏疾病发病死亡规律有详细阐述,认为五脏病发病死亡大都具有一定的规律性,其规律与自然季节天日时辰节律、五运节律、六气节律密切相关,并且可用五行生克乘侮规律进行归纳说明。研究五脏病发病死亡规律对临床防治五脏疾病具有重要指导意义。

以中医运气学理论为依据,探讨了长春地区1949—2007年异常气候年的实际气候变化与中医运气学理论的相关性。同时对1949—2006年长春地区部分流行病资料(包括肝炎、麻疹、流脑、痢疾、伤寒、百日咳、白喉、猩红热、疟疾、流感、脊髓灰质炎、斑疹伤寒)与中医运气学理论推论的异常气候年及平气之年的流行病发病情况进行比较分析,结果发现运气异常年与长春地区部分流行病发病具有相关性。