Objective To estimate the effect of the size of fibroids on obstetric outcomes in twin pregnancy.Metheds The data of twin pregnancy with fibroids who have established their files and delivered from June 2013 to December 2014 in the Beijing Obstetrics and Gynecology Hospital,Capital Medical University were collected,including fibroids' characteristics,maternal demographics,adverse obstetric complications and neonatal outcomes.Results 51 cases were enrolled:34 patients' fibroids were ＜ 5 cm and 17 patients had at least one fibroid ≥ 5 cm.There was no significant difference in the basic demographic characteristics,fibroids' characteristics,adverse obstetric complications and neonatal outcomes between twin pregnant women with fibroids ≥ 5 cm and those with fibroids ＜ 5 cm.The former group had obviously higher degeneration rate than the latter.Diameter modification of fibroids ＜ 5 cm from 11～14 weeks to 28～32 weeks[(2.87 ± 0.94)vs(3.45 ± 1.22),P=0.018)] was significant.Conclutions The effects of the size of fibroids on obstetric outcomes in twin pregnancy are not obvious.Fibroids ≥ 5 cm are more prone to degeneration during gestation.Fibroids ＜ 5 cm could undergo a remarkable growth during the second trimester.

Objective To estimate the effect of uterine fibroids on fetal growth and development and neonatal outcomes.Methods A total of 705 pregnant women with singleton pregnancy and uterine fibroids in the hospital from June 2013 to December 2014 were selected as experimental group,and 705 pregnant women with singleton pregnancy and without uterine fibroids during the same period were selected as control group.The basic demographic characteristics,fetal growth and development indicators during the first,the second,and the third trimesters of pregnancy under B-ultrasound,and neonatal birth status were observed and recorded.Results Compared with control group,the rate of premature birth in experimental group increased significantly (5.7％ vs.2.4％,P =0.002),the gestational age of delivery in experimental group advanced significantly [(38.7± 1.5) weeks vs.(39.1 ± 1.2) weeks,P=0.000)],neonatal birth weight in experimental group decreased significantly [(3 352.8±431.1) g vs.(3 428.9±437.1) g,P=0.001)].For full-term pregnant women,the gestational age of delivery in experimental group advanced significantly compared with control group [(38.8±1.1) weeks vs.(39.2±1.1) weeks,P=0.000)],neonatal birth weight in experimental group decreased significantly [(3 399.3±381.4) g vs.(3 451.3±413.5) g,P=0.016)].For full-term pregnant women of different gestational weeks,there was no statistically significant difference in neonatal birth weight between the two groups (P＞0.05).There was no statistically significant difference in fetal growth and development indicators and neonatal birth status between the two groups (P＞0.05).Conclusion Uterine fibroids increase the risk of preterm birth in singleton pregnancies,but the disease has no significant effect on fetal growth and development.

Objective To explore the effects of different characteristics of intramural myoma on spontaneous delivery.Methods A total of 964 cases of spontaneous delivery who established their medical files in Beijing Obstetrics and Gynecology Hospital affiliated to Capital Medical University from June 2013 to December 2014 were selected,then they were divided into myoma group (482 pregnant women with intramural myoma) and control group (482 pregnant women without myoma).The major characteristics of intramural myoma during early pregnancy under B-ultrasound,progress of delivery,vaginal bleeding,and neonatal conditions were recorded.Results There was no statistically significant difference in progress of delivery,estimated blood loss,and neonatal conditions between the two groups (all P＞0.05).There was no statistically significant difference in progress of delivery,estimated blood loss,and neonatal conditions between the pregnant women in myoma group with different numbers,sizes,and locations of intramural myoma and control group (all P ＞ 0.05).Conclusion Intramural myoma has no significant effect on spontaneous delivery.The number,sizes,and locations of intramural myoma have no significant impact on spontaneous delivery.

宫颈上皮内瘤变(CIN)是与宫颈癌密切相关的癌前病变.CIN分为CINⅠ、CINⅡ和CINⅢ级,反映宫颈癌发展的连续过程,是宫颈癌防治的重要阶段.目前治疗主要包括宫颈环形电切术和冷刀宫颈锥切术两种术式.两种手术均可保留育龄期CINⅡ～Ⅲ级患者的生育功能,同时阻断CIN向宫颈癌发展,但对宫顼有一定程度的破坏,对妊娠及妊娠结局(如早产、胎膜早破、低出生体质量儿等)有不同程度的影响.

Objective To understand the current status of myopia among medical students and to analyze the related affecting factors.Methods A self-administered questionnaire survey was conducted among randomly selected 200 freshmen and sophomores from a medical university in Beijing.The database was built up using EpiData3.1software and SPSS17.0 was used for the analysis of data.Rank-sum test and Spearman′s rank correlation coefficient test were adopted for statistical analysis.Results A total of 183 students had completed the survey.The overall prevalence of myopia was 82.5%,of which mild,moderate and severe myopia accounting for 33.9%,40.4% and 8.2%,respectively.Heredity and poor habits of using eyes were the relevant factors of myopia(P0.05).The correlation coefficients of reading distance,reading posture,frequently lying and playing mobile phone and resting eyes when studying with myopia were 0.247,0.150,0.151 and 0.256,and the correlations were statistically significant(P0.05).Conclusions There is a high prevalence of myopia in medical students.Heredity and environment play an important role in the development of myopia.Appropriate reading habit is supposed to be the most effective way to prevent myopia.