目的:探讨比较精神分裂症与双向情感障碍的认知功能.方法:选择2017年2月—2019年2月我院收治的精神分裂与双相情感障碍患者各60例分为对照组和观察组,其中60例双向情感障碍患者为观察组,其余60例精神分裂症患者为对照组,经过治疗后,比较两组患者的认知功能损害程度以及治疗后阳性与阴性症状量表(PANSS)评分,对所有人进行认知心理测验.结果:两组治疗前认知功能损害程度无统计学意义(P>0.05);经治疗后,观察组患者的数字符号、视觉再生、数字广度倒背评分高于对照组(P<0.05);W C S T分类个数多于对照组(P<0.05),错误数、连续错误数少于对照组(P<0.05);两组患者的数字广度顺背、连线测试A、B评分之间的差异无统计学意义(P>0.05);治疗后,观察组患者的一般精神、阳性、阴性症状评分以及总分低于对照组(P<0.05).结论:经过治疗后,双向情感障碍患者的认知功能损害程度较精神分裂患者低,双向情感认知障碍患者的认知功能比精神分裂患者要恢复的好.

Objective to analyze medication methods and clinical effects of 30 cases manic patients before electroconvulsive therapy. Methods choose 30 cases mania patients in our hospital from February 2017 to February 2018, divide them into two groups according to admission number randomly, 15 in each group. Both groups were treated with electroconvulsive therapy. On this basis, control group was treated with routine medicine only, while observation group with lithium carbonate. Compare specific conditions of two groups. Results total effective rate of observation group was significantly higher than control group, and BRMS score decreased (P< 0.05); adverse reactions showed no difference between two groups (P> 0.05). Conclusion it is difficult to achieve ideal results after non-convulsive electroconvulsive therapy for manic patients, and medication before treatment can reduce BRMS, and enhance clinical effect, which has high clinical value.

目的:主要研究团体心理治疗对抑郁症患者疗效及生活质量的影响.方法:选取我院于2015年7月—2016年5月间收治的89例抑郁症患者,随机将其分为治疗1组、治疗2组,其中治疗1组患者45例,接受团体心理治疗;治疗2组患者44例,单方面接受药物治疗,比较两组患者治疗效果.结果:在经过治疗后,两组患者的HAMD评分与治疗前相比均有明显下降,但分别比较两组患者评分的下降幅度,治疗1组优于治疗2组(P<0.05);比较两组患者GQOLI-74各个维度的评分情况,治疗1组明显优于治疗2组(P<0.05).结论:团体心理治疗对抑郁症患者疗效与生活质量产生深远影响,能快速改善患者临床症状,强化患者社会能力,因此应该在临床上做进一步推广.

OBJECTIVE:To conduct meta-analyses of all published association studies on the HTR2C -759C/T (rs3813829) polymorphism and olanzapine-induced weight gain in schizophrenia patients and on the HTR2C -759C/T, -697G/C (rs518147) and rs1414334:C> G polymorphisms and olanzapine/clozapine/risperidone-induced metabolic syndrome in schizophrenia patients.METHODS:Eligible studies were identified by searching PubMed and Web of Science databases. Meta-analyses were performed using Cochrane Review Manager (RevMan, version 5.2) to calculate the pooled odds ratio (OR) and its corresponding 95% confidence interval (CI).RESULTS:Our meta-analyses revealed both a significant positive association between the rs1414334 C allele and olanzapine/clozapine/risperidone-induced metabolic syndrome and a marginally significant positive association between the -697C allele and the induced metabolic syndrome in schizophrenia patients, but no significant association between the -759C/T polymorphism and the induced metabolic syndrome in schizophrenia patients. Our analysis further revealed a pronounced trend toward a significant negative association between the -759T allele and high olanzapine-induced weight gain and a trend toward a significant positive association between the -759C allele and high olanzapine-induced weight gain in Caucasian schizophrenia patients.CONCLUSIONS:Our results support that HTR2C polymorphisms play a role in antipsychotic-induced metabolic disturbance. More association studies are needed to further elucidate association of different HTR2C polymorphisms and antipsychotic-induced metabolic disturbance.

目的 观察奥氮平诱导性肥胖大鼠血清和大脑纹状体肿瘤坏死因子-α (TNF-α)含量的影响.方法 40只SD雄性大鼠随机分为对照组和奥氮平组,各20只,前者采用普通饲料喂养,后者在普通饲粮喂养基础上灌胃奥氮平(1.2mg· kg1)4周建立奥氮平诱导肥胖大鼠.采用酶联免疫测定法测定血清中TNF-α的含量,生化比色法测定血清葡萄糖(FBS)含量,对脑组织采用HE染色观察形态学变化,采用免疫组织化学方法观察两组大鼠脑组织中TNF-α的表达.结果 与对照组比较,奥氮平组大鼠的体重、血糖、血脂和血清TNF-α水平和纹状体TNF-α蛋白表达均有不同程度的升高,差异有统计学意义(P＜0.01).结论 奥氮平可以导致大鼠体重增加,糖脂代谢紊乱,血清及纹状体TNF-α升高,通过调节TNF-α异常变化可能改善奥氮平诱导肥胖大鼠中枢摄食活动.

目的研究吸烟对人体免疫球蛋白的影响。方法调查80例人群吸烟状况,其中吸烟者40例,不吸烟者40例,采用免疫透射比浊法测定其血清中IgG、IgM、IgA的含量。结果吸烟者血清中IgG、IgM、IgA的含量低于不吸烟者,差异有统计学意义(P<0.05)。结论吸烟可引起免疫球蛋白减少。