糖化血清白蛋白(glycated albumin,GA)是葡萄糖与血清白蛋白发生非酶促糖基化反应的产物,因蛋白在体内的半衰期较短,17～19d,故GA可反映近2～3周血糖控制的总体水平,临床上主要用于评价糖尿病患者短期糖代谢控制的情况,并指导治疗方案的调整[1].现拟对GA的检测方法、参考范围及其与糖尿病慢性并发症的研究进展进行综述.
Objective: To investigate the relationship between glycated albumin levels and early diabetic nephropathy in patients with type 2 diabetes mellitus.Methods: From January 2012 to June 2012,100 patients with type 2 diabetes mellitus in our hospital were enrolled in the study.We used liquid enzymatic to detect glycated albumin,and compare with 100 cases of non-diabetic nephropathy as the control group.Results: Glycated albumin in diabetic nephropathy group was higher than that in non-diabetic nephropathy group,there were statisti-cally significant differences on glycated albumin among the 2 groups(P0.05).Logistic regression showed that glycated albumin was an independent risk factor impacting on the incidence of diabetic nephropathy and the severity of the disease.Conclusion: Glycated albumin is an independent risk factor impacting in patients with type 2 diabetes mellitus diabetic nephropathy,and plays an important role in the pathogenesis of diabetic nephropathy.
<正>流行病学资料表明,全球糖尿病患者总人数已超过2.4亿。据世界卫生组织(WHO)调查资料证实,糖尿病患者的年增长率达10%左右。中国是全球糖尿患者数最多的国家之一,日前1项调查表明中国糖尿病患病人数已跃居世界第2位[1]。糖尿病控制和并发症试验(DCCT)和英国前瞻性糖尿病研究(UKPDS)表明血糖水平和微血管并发症、大血管并
