Objective To observe the efficacy and toxicity of treatment of gastric cancer with combined sodium cantharidate vitamin B6 injection and postoperative chemotherapy. Methods The article reviewed the clinical observation of the fifty cases of gastric cancer with combined sodium cantharidate vitamin B6 injection and postoperative chemotherapy from March,2008 to September,2009.After chemotherapy,the level of the adverse reaction and toxicity was compared between the treatment group(sodium cantharidate vitamin B6 injection and chemotherapy) and control group(pure chemotherapy). Results The incidence rates of neutropenia,nausea and vomiting,abnormal liver function in treatment group were 48%,44%,and 4%,respectively,and those in control group were 76%,72%,and 20%,respectively,there were statistically significant differences between the two groups(P0.05).No statistically significant difference was found in other aspects of adverse reactions between the two groups. Conclusions The combined therapy of sodium cantharidate vitamin B6 parenteral solution and postoperative chemotherapy for gastric cancer can improve patient's disease-resistant ability,decrease toxic reaction rate,and improve the therapeutic effect,which is worthy of popularization.

目的:观察斑蝥酸钠维生素B6注射液对晚期结直肠癌患者的治疗效果。方法:选取有明确诊断和分期的晚期结肠癌患者52例,随机分为斑蝥酸钠维生素B6治疗组26例和常规化疗的对照组26例。治疗组用奥沙利铂联合LV、FU的FOLFOX4方案,并于化疗的第一天起即用5%葡萄糖液+斑蝥酸钠维生素B6注射液0.5mg,每天1次至化疗结束,为1疗程。对照组仅用奥沙利铂联合LV、FU的FOLFOX4方案。3个疗程后行疗效评估。结果:斑蝥酸钠维生索B6注射液对晚期结直肠癌疗效较对照组明显提高(P<0.05),治疗组总有效率45.7%(CR+PR),对照组总有效率32.8%(CR+PR)。治疗组治疗前后全身功能状况Karnofsky评分亦差异有显著性(P<0.05),对照组治疗前后Karnofsky分无差异。在毒副作用上治疗组明显低于对照组。结论:斑蟹酸钠维生素B6注射液对晚期结肠癌能提高有效率及稳定率,改善全身体力状态及降低不良反应。