Breast cancer (BC) is a fatal malignancy, which has a high incidence and mortality across the world. Circular RNAs (circRNAs) have crucial roles in tumor initiation and progression. In this project, a newly found circRNA, circ_0103552 was explored. Quantitative real-time polymerase chain reaction was applied to measure its expression in the patients' tissue specimens and cells. In addition, Fisher's exact test, Kaplan-Meier curves and Cox regression model were conducted to discover the clinical significance of circ_0103552. Cell viability, clone-forming ability, apoptosis, and metastatic properties of BC cells were evaluated by gain/loss-of-function assays. Dual luciferase reporter assay was applied to illuminate its mechanisms. As data indicated, circ_0103552 was significantly elevated in BC tissue samples and cells. In addition, its expression correlates with clinical severity and dismal prognosis. Furthermore, circ_0103552 could facilitate cell growth, clone-forming ability, migration and invasion, and decrease apoptotic cells. For the mechanism exploration, circ_0103552 could directly sponge miR-1236 to execute oncogenic activities in BC cells. In summary, this study provides a novel circRNA in tumorigeneis and progression of BC and may help to develop effective therapeutic target for this devastating disease.

目的:探讨临床路径联合芎红乌草桂枝汤对缓解化疗后手足综合征的影响.方法:选取2014年8月至2015年9月间于我院治疗的手足综合征患者共96例,将其以数字随机分组的方式均分为实验组及对照组,每组48例.结果:两组总体治疗效果比较(x2 =71.598,P=0.000),疼痛缓解率方面比较(x2=5.790,P=0.030),差异均具有统计学意义(P＜0.05).结论:临床路径联合芎红乌草桂枝汤对缓解化疗后手足综合征的效果显著,值得于临床中进一步推广使用.

目的 研究芎红乌草桂枝汤治疗卡培他滨致手足综合征的临床护理效果.方法 选取60例卡培他滨致手足综合征患者,随机等分为对照组与试验组.两组患者均给予基础护理,试验组给予芎红乌草桂枝汤浸泡手足,对照组给予安慰剂浸泡,比较两组患者的治疗效果、疼痛程度及治疗满意度.结果 治疗有效率、疼痛缓解率和治疗满意度等方面比较均具有统计学意义(P＜0.05).结论 对于卡培他滨致手足综合征的患者在基础护理上辅以芎红乌草桂枝汤浸泡手足疗效显著,减轻患者疼痛,提高患者满意度,临床上值得推广.

目的观察中药益气养阴活血方治疗卡培他滨相关性手足综合征的临床疗效。方法将50例卡培他滨单药化疗的肿瘤患者随机分为中西医结合治疗组和空白对照组,各25例。分别观察两组手足综合征出现例数及分级。结果中西医结合治疗组、西药对照组在手足综合征发生率及卡培他滨剂量调整方面均低于空白对照组(均<0.05)。结论益气养阴活血方与XELOX方案同步应用,能提高患者对卡培他滨化疗的耐受性。

目的探讨化疗相关性口腔真菌感染较好的护理措施。方法回顾性分析40例因化疗导致口腔真菌感染的患者,随机分为实验组和对照组各20例。对照组口腔护理后加碳酸氢钠溶液含漱及联合静脉点滴氟康唑;实验组口腔护理后加碳酸氢钠溶液含漱,用酮康唑与香油悬浮液涂抹口腔黏膜。观察比较两组治愈时间、疼痛缓解率、治疗相关费用。结果实验组治疗效果明显优于对照组,口腔真菌感染治愈的平均时间少于对照组,两组比较有统计学差异。结论在口腔护理后加碳酸氢钠溶液含漱基础上用酮康唑与香油悬浮液涂抹口腔黏膜能够缩短化疗相关性口腔真菌感染的治愈时间,提高了临床治疗疗效,值得临床应用推广。

OBJECTIVE To analyze the distribution and drug resistance of the fungi causing chemotherapy-associated infections and explore the nursing countermeasures to prevent the infections in the chemotherapy patients.METHODS A total of 860cases of patients who underwent chemotherapy in 2008-2010were enrolled in the study,the causes of the infections were analyzed,then the bacterial culture and the drug susceptibility testing of the pathogens causing oral infections were performed.RESULTS Of 860cases of patients,the nosocomial infections occurred in 175cases after the chemotherapy with the infection rate of 20.3%,among which there were 96(11.2%)cases with fungal infections and 68(7.91%)cases with oral fungal infections.Candida albicans and Candida tropicalis were the predominant species of fungi,accounting for 61.3% and 16.0%,respectively.The drug resistance rates of the C.albicans to flucytosine,clotrimazole,and bifonazole were the lowest,which were 6.5%,6.5%,and 4.3%,respectively;C.tropicalis was rarely resistant to mycophenolate triazole and bifonazole;the C.glabrata was rarely resistant to bifonazole and streptozotocin;the C.krusei was rarely resistant to nystatin and bifonazole.CONCLUSION The fungi are the major pathogens causing oral infections in the chemotherapy patients and can produce certain drug resistance.Weak alkaline rinse slobber should be used to prevent the fungal infections in the nursing process.Once the infections occurs,the pathogenic bacteria should be isolated and cultured,and the sensitive antibiotics should be chosen for timely treatment so as to prevent the emergence or drug resistant bacteria.

目的 探讨重组人粒细胞集落刺激因子治疗化疗患者口腔黏膜溃疡的临床效果及应用价值.方法 回顾性分析40例经化疗后出现口腔黏膜溃疡患者的一般资料,按照随机、对照的原则分为观察组和对照组各20例.对照组患者采用普通常规的口腔护理,观察组采用重组人粒细胞集落刺激因子进行护理治疗.观察和比较2组患者的护理治疗效果及口腔黏膜炎愈合的平均时间.结果 观察组临床总有效率为100.0％,对照组临床总有效率为60.0％,2组比较,观察组治疗效果明显优于对照组；观察组患者口腔黏膜溃疡愈合的平均时间为(2.4±1.5)d,对照组患者口腔黏膜溃疡愈合的平均时间为(4.3±1.9)d,2组比较,观察组患者溃疡愈合的平均时间明显短于对照组.结论 临床采用重组人粒细胞集落刺激因子对化疗后出现口腔黏膜溃疡的患者护理治疗效果较好,能够加速患者口腔黏膜炎的愈合,改善患者的病情及预后,提高患者的生存质量,值得临床进一步大胆推广应用。

目的探讨责任制护理带教的途径与效果。方法通过对传统护理带教方法的分析,发现弊端,探寻最佳护理带教策略,提高护理带教的水平,提高护生的护理实践能力。结果护生的护理理论、实践能力均有较大程度的提高,综合、系统护理能力明显提高。结论责任制护理带教极大的提高了实习护生的整体护理观念,掌握了专科系统的护理方法,提高了护生对护理工作系统服务的掌握程度及水平。