Objective: To investigate the expression of PTEN and MDM2 in transitional non-small cell lung cancer(NSCLC).Methods: The expressions of PTEN and MDM2 were determined by immunohistochemical method in 56 cases of primary lung cancer and 20 case of normal lung tissue.Results: The expression of PTEN in 56 cases of lung carcinoma was 48.21% while which was 95% in 20 cases of normal lung tissues(p0.05).The expression of PTEN was related to the degree of cell differentiation,clinical stage and lymph node metastasis.The expression of MDM2 in 56 cases of pulmonary carcinoma was 53.57%,while which was10% in 20 cases of normal lung tissues(p0.05).The expression of MDM2 was related to the degree of tumor cell differentiationclinical stage and lymph node metastasis(p0.05).There was negative correlation between expression of the PTEN and MDM2 in NSCLC(p0.05).Conclusion:Abnormal expression of PTEN,MDM2 may play an important role in the malignant progression of NSCLC.

肺癌病人出现血小板减少多考虑为化疗所致毒副作用;而免疫性血小板减少症为自身免疫性疾病,二者同时发生在一例患者身上相对少见,本文将哈尔滨医科大学附属第三医院曾诊治的肺癌合并免疫性血小板减少症一例报道如下.