Objective To investigate the risk factors of missed abortion to decrease the incidence of repeated abortions.Methods A questionnaire survey was performed for 200 patients with missed abortion who were treated firstly in our hospital from January 2013 to December 2014.The results were statistically analyzed by SPSS 11.0 software.Results The common cause of missed abortion was the infection factors,which accounted for 31.5％.The incidence of missed abortion was significantly increased in the age range of 26 ～ 30 years and 31 ～ 35 years.The more the number of times of artificial abortion,the higher the probability of incidence of missed abortion.Among 200 patients,the patients whose serum levels of calcium,iron,zinc and lithium were lower than the normal value accounted for 90％,and the difference was statistically significant (P ＜ 0.05).Among 200 patients,the patients with lower levels of progesterone who had missed abortion accounted for 48 ％,the patients with high levels of lactotropin accounted for 30％,and the patients with low levels of estrogens accounted for 30％,the difference was statistically significant (P ＜ 0.05).Conclusion Preventing genital tract infection,improving the immune status of pregnant women and avoiding high radiation environment can reduce the incidence rate of missed abortion in early pregnancy.The sufficient trace element concentration and sex hormone levels play an important role in embryo development and maintenance of pregnancy.It is suggested that the best child-bearing age should be 25 ～ 29 years,and it is important to cherish every chance of conception and reduce blindly induced abortion.

Objective To analyze the hemodynamics charateristics of patients with missed abortion and early pregnant women by color Doppler ultrasonography in order to provide the basis for early diagnosis of missed abortion.Methods The transvaginal color Doppler examination was performed in 200 cases of missed abortion and 200 cases of normal early pregnancy.The hemodynamic indexes of uterine artery and spiral artery including pulsatility index (PI),resistance index (RI),systolic/diastolic flow rate ratio (S/D) were detected and statistically analyzed.Results RI and PI in uterine arteries and spiral arteries in missed abortion group were significantly higher than those in normal early pregnancy group (P ＜ 0.05),and the S/D in uterine arteries and spiral arteries in missed abortion group was higher S/D than that in normal early pregnancy group,but there was no significant difference between two groups (P ＞ 0.05) Conclusion The monitoring of uterine artery hemodynamic parameters has important clinical significance in.diagnosis of missed abortion.

目的:比较不同糖耐量状态血清脂联素水平的比较及其相关因素.方法:选取根据1999年WHO制定的糖尿病诊断标准,将2015年1月-2016年12月在我院健康查体中心查体人员2856人,分为糖耐量正常组:A组1089例,糖耐量减低组:B组836例,糖尿病组:C组931例.对比三组病人的一般情况及血清脂联素水平,通过单因素分析及多因素回归分析,分析不同糖耐量状态血清脂联素水平及其相关因素.结果:通过多因素Logistic回归分析发现,年龄、TC、TG、LDL-C为糖尿病的独立危险因素,而脂联素为糖尿病发病的保护因素.(P<0.05).结论:血清脂联素水平在糖耐量减低期即呈下降趋势,血清脂联素水平有助于T2D M早期预测及诊断.

目的:津力达颗粒对2型糖尿病病人胰岛β细胞的保护作用.方法:集2016年1月—2016年12月在我院内分泌科诊断的2型糖尿病患者408名.根据患者自愿的原则,随机分为两组,实验组208名,对照组200名.两组患者严格控制饮食及运动疗法,并给予二甲双胍缓释片加胰岛素治疗对照组予胰岛素和二甲双胍治疗,实验组在此基础上加服津力达颗粒,治疗8周后观察两组患者治疗前后血糖控制指标及胰岛β细胞功能指数:FPG、2hPG、HbAlc、HOMA-β及两组患者治疗前后中医疗效比较.结果:两组患者治疗后空腹及餐后2h血糖、糖化血红蛋白均明显降低,实验组降低更明显;两组患者治疗前后中医疗效,治疗组优于对照组.结论:津力达津力达颗粒对2型糖尿病病人胰岛β细胞有明显保护作用,是治疗2型糖尿病的合理选择.

Objective To analyze the changes of tumor necrosis factor alpha (TNF-α), free fatty acid (FFA) and adiponectin (APN) and its influencing factors in patients with different glucose tolerance.Methods From March 2014 to March 2015, select the first hospital of Shijiazhuang City Department of endocrine treatment of type 2 diabetes mellitus (DM group), impaired glucose tolerance (group IGT), patients with the same period in healthy physical examination in our hospital patients (NGT group), 30 cases in each group respectively as the research object, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), triacylglycerol (TG), total cholesterol (TC) and insulin resistance index (HOMA-IR), TNF-α, FFA and APN alpha detection index, and risk factor analysis.Result Comparison of serum TNF-α, FFA levels: NGT group <IGT group <DM (F=2.711,P=0.014;F=3.274,P=0.008), serum APN level comparison: group >IGT group >DM group (F=3.014,P=0.011).TNF-α , FFA and TG, FPG, FINS, HOMA-IR, HbA1c in the DM group was significantly positive correlation (r=0.410,r=0.274,r=0.428,r=0.490,r=0.400,P=0.000;r=0.420,r=0.350,r=0.370,r=0.480,r=0.410,P=0.000), APN was negatively correlated with TG, FPG, FINS HOMA-IR, HbA1c (r=-0.410,r=-0.370,r=-0.370,r=-0.490,r=-0.400,P=0.000).Hypertriglyceridemia, hypercholesterolemia, hypertension, HOMA-IR, TNF-α, FFA, APN were risk factor of diabetes mellitus [OR (95%CI)=1.739 (1.286-2.353), OR (95%CI)=1.486 (1.096-2.016),OR(95%CI)=1.743 (1.290-2.356),OR (95%CI) =2.302 (1.707-3.104), OR (95%CI) =1.624 (1.135-2.321), OR (95%CI) =1.212 (1.081-1.359),OR (95%CI) =0.665 (0.500-0.884)].Conclusion TNF-α, FFA and APN may play an important role in the occurrence and development of diabetes, so it is necessary to strengthen the early intervention of lipid metabolism and related fat factors.

目的应用瞬时波强技术(WI)的相关参数检测缺血性心肌病患者左室功能。方法用WI软件测量分析34例缺血性心肌病患者和30例正常对照组,采集WI相关参数,即瞬时加速度波强(W1),瞬时减速度波强(W2),负向波面积(NA),射血时间(W1-W2),射血前期(R-W1)。结果与正常对照组比较,缺血性心肌病组W1明显减低(P<0.01);W2和NA减低(P<0.05);W1-W2明显缩短(P<0.05);R-W1差异无统计学意义(P>0.05)。结论 WI评价左室功能,为临床评价心力衰竭的程度提供了新的途径和方法。

目的探讨颈动脉瞬时波强(WI)评价慢性肾衰竭(CRF)患者左室功能改变的价值。方法用WI技术检查CRF患者30例及正常对照组30例,采集相关参数W1、W2、NA、R-W1、W1-W2。结果与正常对照组比较,CRF患者W2、NA增高(P<0.05),W1减低(P<0.05),W1-W2和R-W1差异无统计学意义(P>0.05)。结论 WI技术是评价CRF患者左心功能改变的一种新方法。