目的 观察中药人参和有氧运动大鼠创面修复过程TNF-α和TGF-β1的影响,探讨其对创面愈合过程中可能的影响机制.方法 大鼠随机分为三组:模型对照组(A)、人参+有氧运动组(B),人参+安静组(C).采用付氏改良造模方法,在动物造模治疗后第5、12天进行断尾取血,ELISA法测TNF-α、TGF-β1.结果 治疗后5d:A组的TNF-α含量最高,与B、C组比较,具有显著性差异(P＜0.01),提示A组仍然处于高度的免疫应激状态；在TGF-β1方面,C组含量较高,与其它各组比较,有显著性差异(P＜0.01),提示人参对创面愈合有促进作用.在治疗后第12天,B组的TGF-β1升高幅度明显,与A、C组比较,分别具有显著性差异(P＜0.01),提示有氧运动促进创面修复后期成纤维细胞的增殖方面作用明显.结论 人参和适量有氧运动干预能改善大鼠创面免疫能力低下状态,提高其免疫应激能力和免疫功能,均能促进成纤维细胞的增殖,其中有氧运动在大鼠创面修复后期作用尤为显著,提示后期进行适当的有氧运动有助于创面的修复.

目的：研究人参对大鼠创面愈合的作用及血清TNF-α、IL-1β、TGF-β1的影响。方法：30只SPF级8周龄SD大鼠随机均分为健康对照组、模型安静组、模型人参组,雌雄各半。麻醉及消毒后切除大鼠背部2 cm方形全层皮肤造模。伤后第3天开始人参灌胃,持续14 d。常规观察和测量创面愈合情况;伤后第10天、第17天断尾取血备血清,ELISA法测IL-1β、TNF-α、TGF-β1。结果：人参使皮肤创面愈合时间加快（2±0.5）d,愈合质量较好;伤后第10天、第17天人参组血清TNF-α、IL-1β水平均明显低于模型安静组（P〈0.05）;TGF-β1水平在第10天明显高于模型安静组（P〈0.05）,第17天与模型安静组比较无显著性差异（P〉0.05）。结论：人参可能通过改善创面炎症免疫反应及TGF-α、IL-1β、TGF-β1相关通路促进创面愈合。

目的:研究有氧运动干预对大鼠创面愈合的影响及免疫炎症方面的可能机制,为运动在创面愈合中的应用提供参考.方法:SPF级8周龄健康SD大鼠40只随机分为健康安静组(A组)、创伤安静组(B组)、伤后运动组(C组)、伤前长期运动及伤后运动组(D组),雌雄各半.切除背部皮肤进行创伤造模.D组伤前有氧运动锻炼4周,C、D组伤后给予有氧运动干预.伤后第3、10、17天断尾取血备血清,ELISA法测血清IL-1β、TNF-α、TGF-β1,同时观察创面愈合情况.结果:两种方式的运动干预使皮肤创面愈合加快2～3d;伤后大鼠血清TNF-a和IL-1β含量明显上升(P＜0.05),C、D组低于B组(P＜0.05),并随愈合进展逐步下调(P＜0.05),而C、D组血清TGF-β1整体低于B组(P＜0.05).结论:有氧运动可能通过改善创伤机体免疫炎症反应及多个细胞因子的平衡来促进创面愈合.

创面愈合是一个非常复杂的过程,笔者通过对成年大鼠创伤前后的运动干预,探讨运动干预对大鼠创面愈合过程中免疫功能和生长因子的影响,旨在揭示运动干预对创面愈合影响的可能机制,为运动疗法在创面愈合的临床应用提供实验参考.

Objective: To study the effect of ginseng on wound healing and serum TNF-α,IL-1β,TGF-β1 of rats.Methods: 30 SPF SD rats aged 8 weeks were randomly divided into control group,model of quiet group,model of ginseng group,half male and half female.2cm squares of rat back skin were cut off to make model after anesthesia and disinfection.On the 3rd day after injury,the rats were given gastric perfusion of ginseng for 14D.Regular observation and measurement of wound healing.On the 10th day and 17th day after injury,the tail was cut to take blood serum;ELISA method was used to test IL-1β,TNF-α,TGF-β1.Results: Ginseng made the healing time of skin wound increase 2 ± 0.5 d,the healing quality was better;On the 10th day and 17th day after injury,serum levels of IL-1β,TNF-α in ginseng group were significantly lower than those of model group(P<0.05);TGF-β1 level on the 10th day was significantly higher than that in model group(P<0.05),on the 17th day,there was no significant differences(P>0.05) compared with the model group.Conclusion: Ginseng may promote the wound healing by improving the wound inflammatory immune response and the relative pathways of TGF-α,IL-1β,TGF-β1.

Objective According to the intervention of far infrared ray physiatrics in traumatized rats to explore the immune and the cytokine mechanisms of the far infrared ray intervention.Methods By selecting 30 SPF grade healthy SD big rats of eight years old as experimental subjects,randomly divided into health+quiet group(A),injured+quiet group(B),injured+ infrared+ quiet group(C).The method created by Fu Xiao-bing adopted,after mold-building treatment,the rats were cut off tails to obtain blood,centrifugated to get blood serum,measuring IL-1β,TNF-a,TGF-β1 with ELISA method.Results After mold building,the levels of IL-1βand TNF-α were increased obviously in injured rats.In group C,the levels of IL-1βand TNF-α were significantly lower than those in group B(P0.01).TGF-β1 in group C was significantly higher than that in group B(P0.05).Conclusion The intervention of far infrared ray can improve immuno-stress ability of injured rats,weaken the persistent inflammatory reaction of wound surface,promote fibroblastic proliferation.The immune function coincides with the changed TGF-β1.

Breathing is the marrow and key of the Yoga,which is different from other events' one that is controlled by mind.This article analyses the Yoga mind breathing's characteristics and its effections to the pulmonary ventilation and lung vital capacity.