目的观察益宫颗粒治疗产后恶露不绝的安全性。方法采用随机对照研究方法,对益宫颗粒疗效评价的同时,以生命体征、血尿便常规、凝血功能、肝肾功能、心电图评价安全性。结果本次临床试验未观察到不良反应,未观察到试验药物对心、肝、肾功能、血液系统有异常影响。结论益宫颗粒是一种安全有效的治疗产后恶露不绝(中医属气虚兼血瘀证)的新药。

孕妇外周血中游离胎儿DNA的发现为无创性产前诊断开辟了崭新的途径.随着有关研究的深入和检测手段的发展,母血循环胎儿DNA被越来越多地应用到对病理性妊娠和胎儿疾病的研究中,为预防和控制新生儿发病率及死亡率提供了一条快速、安全、灵敏度高、特异性强的非损伤性产前诊断方法,对优生优育、提高人口素质具有明显的社会意义.

目的 探索一种利用孕妇血浆中游离DNA检测胎儿ABO血型用于母婴ABO血型不合的无创性产前诊断方法.方法 用硅胶膜柱提取的方法从50例13～37孕周可疑母婴ABO血型不合的孕妇血浆中提取胎儿DNA,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法检测胎儿ABO血型.结果 50例样本中,检出32例,检出率64%(32/50),出生后血清学证实28例诊断正确,诊断正确率87.5%(28/32).结论 利用孕妇血浆中游离DNA检测胎儿ABO血型可行,对诊断和预防因母婴ABO血型不合所致溶血病的发生具有重要意义.

目的观察活血化瘀促进产后子宫复旧的疗效。方法将220例自然分娩初产妇随机分为观察组107例,对照组103例,分别于产后24h内开始口服益宫颗粒和对照药促进子宫复旧,使用评分法对两组阴道恶露量及恶露性状、子宫收缩痛进行比较。结果用药后3和7d止血率、止血疗效明显高于对照组,两组间有显著性差异(P<0.01)。结论益宫颗粒能明显促进子宫复旧。

Objective To investigate the complication rate of gynecological laparoscopies of benign diseases.Methods One thousand three hundred and forty laparoscopic surgeries were carried out from march 2004 through june 2009,included 990 cystectomies and salpingectomies,153 adnexectomies,110 myomectomies,and 87 total hysterectomies.Results Complications occurred in 25 cases,the over complication rate was 1.87%(25/1 340).Complication rate was 0.30%,3.27%,7.27% and 10.34% in cystectomies and salpingectomies,adnexectomies,myomectomies and total hysterectomies repectively.9(36.00%)complications related to puncture and pneumoperitoneum.2(8.00%)introaperative complications occurred during the laparoscopic surgery.14(56.00%)complications occurred during postoperative stage.Conclusion Operative gynecologic laparoscopy is associated with acceptable morbidity rate,but can not be overlooked.Complications seems related to difficulty of the operation.

Objective:To study the expression and significance of Fhit and survivin in cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC). Methods: S-P immunohistochemical method was used in this study. Results: With the development of CIN,Fhit aberrant expression and positive expression of survivin were increased with significant difference.(P0.05). None of the clinical pathologic parameters showed a correlation with Fhit expression. Expression of survivin in CSCC had significant correlations with tumor differention (P0.05), clinical stage (P0.05) and lymphatic metastasis (P0.05).Correlation was also found between Fhit aberrant expression and survivin expression in CSCC. Conclusion: Fhit aberrant expression occurred in CIN and it can be used as a mark in the detection of CSCC in an earlier stage. Survivin is correlated with tumorigenesis, invasion, and metastasis. Fhit and survivin may play important roles in the occurrence and development of CSCC.

Objective To observe therapeutic effects of compounded zedoary turmeric oil foam combined with microwave therapy on Ⅱ and Ⅲ degrees of cervical erosion.Methods 195 women with cervical erosion were divided into two groups: single microwave therapy group(group A) and compounded zedoary turmeric oil foam combined with microwave therapy group(combined treatment group,group B) randomly.89 women with cervical erosion in the group A were treated with single microwave and 106 women with cervical erosion in the group B were treated with compounded zedoary turmeric oil foam before and after microwave therapy for 10 days.All women in the two groups were followed-up at 1month and 2 months after treatment and their therapeutic effects were observed.Results There were significant differences in curative rate(χ2=10.93,P0.01;χ2=12.31,P0.01),effective rate(χ2=16.30,P0.01;χ2=4.06,P0.05),vaginal apocenosis(χ2=19.15,P0.01) and transvaginal bleeding(χ2=29.38,P0.01) between the two groups.The therapeutic effect of combined treatment was superior to single microwave therapy group,and less side effects were found.ConclusionThe therapeutic effect of combination of compounded zedoary turmeric oil foam and microwave therapy is satisfactory for cervical erosion and worthy to be recommended.

Objective:To evaluate the importance and safety of laparoscopy in the treatment:of benign adnexal diseases. Methods:We retrospectively analysed 325 cases of benign diseases which were operated with laparoscopy.Those patients with benign adnexal tumor,or ectopic pregnancy,oviduct adhension,fimbriated extremity of fallopian obstruction,ovarian rupture, chocolate cyst or paraovarian cyst,were operated with laparoscopy.Based on the different situations of illness,different operation methods were performed,including oophorocystectomy,adnexectomy,salpingectomy and salpingostomy.Results:The rate of la- paroscopic operation is 42.54% of all the operation in the same period and the achievement ratio is 100%.Only five cases(1.54%) occurred with complications.Conclusion:If the indications are appropriately controlled,most of the operations on adnexal dis- eases could be made with a laparascope and the complications could be reduced.

现将自1998年5月至2006年5月收治的55例妊娠期肝内胆汁淤积症(ICP)的治疗体会,报道如下. 临床资料 1 一般资料 55例患者年龄20～36岁,平均23.8岁.初产妇48例,经产妇7例;孕早期1例,孕中期45例,孕晚期9例.实验室检查:丙氨酸氨基转移酶(ALT):正常2例,升高低于3倍以下18例;总胆汁酸(TBA):15～92.5 μmo/L;血总胆红素(TBIL)全部超过正常,其中21例在80μmo/L以下;碱性磷酸酶(ALP)均超过正常范围.

目的:探讨ABO血型孕妇妊娠期血清学的IgG抗体效价与新生儿ABO溶血病的关系及有效治疗方法。方法:选择血型为“O”型Rh阳性、其丈夫血型为非“O”型孕妇分娩的新生儿412例,孕期进行血清红细胞抗A或抗B的IgG抗体测定,效价≥1∶64者为阳性,分娩时取脐静脉血做红细胞4项试验,新生儿确诊为母儿ABO血型不合溶血者,观察黄疸情况,必要时测定其红细胞、血红蛋白、网织红细胞、总胆红素及其分类等,随访新生儿3月。结果:妊娠次数在2次及2次以上者,其IgG抗A(B)阳性率大于1次妊娠者,差异有显著性(P<0.05);有不良妊娠史者发生率高,差异有显著性(P<0.05);抗体效价的高低与新生儿溶血病的发生成正比关系;对效价≥1∶64者进行相关治疗,新生儿状况良好。结论:对妊娠次数较多或有不良妊娠史的孕妇在孕早期即应进行Ig抗A(B)抗体效价的测定,并进行相关治疗,整个孕期动态观察IgG抗体效价的变化,对新生儿密切观察和治疗预后良好。

Objective:To discuss the correlation between postmenopausal bleeding age,the term of menopause,thickness of en- dometrium,and benign and malignant diseases.Methods:110 patients with postmenopausal bleeding more than i year between 2003 and 2005 were accepted,whose clinical and pathological examinations were analyzed.Results:The pathologic diagnosis ofpostmenopausal bleeding showed that non-organic diseases was 44(40%),benign diseases26(23.6%),diseases40(36.4%),hypertension 22(20%),obe- sity adiposis 17(15.5%).Conclusion:Most postmenopausal bleeding is induced mainly by benign and non-organic diseases,secondarily malignant tumors.The older the age is,the longer the menopausal period is,the thicker the endometrium is,and the higher the morbidity of malignant tumors is,in which,IUD,hypertension,and obesity adipos are influencing factors.

目的:探讨人工流产术中不同镇痛方法对减轻孕妇的痛苦,预防人工流产并发症发生的效果.方法:选择异丙酚静脉注射,美菲康(盐酸吗啡控释片)口服,安定静脉注射三种方法用于人工流产术中扩宫镇痛,比较其疗效,并观察其人工流产并发症的发生情况.结果:美菲康自动扩宫总有效率为98.4 %,镇痛总有效率为95.0%,经检验与其它方法相比有显著差异,同时能明显降低人工流产并发症的发生率(P<0.01),术中出血亦较少.结论: 美菲康应用于无痛人工流产,方便、安全、扩宫镇痛效果满意.

到目前为止,新生儿窒息仍然是危及新生儿生命的主要病因.在我国新生儿窒息发病率为6-8%.其中,死亡率约为10%[1],约有12%的新生儿因重度窒息造成神经系统后遗症.

资料与方法 1 临床资料选用1997年5月至1999年11月在我院住院分娩的妊高征患者38例,年龄21～39岁,平均30岁,孕周29～41+4周,平均35+2周;初产妇32例(其中2例为双胎),经产妇6例;农民29例,职工9例.并选用同期住院条件无差异的妊高征患者36例作对照. 2 诊断标准按<妇产科学>第四版妊高征诊断标准.38例中,重度妊高征21例(其中先兆子痫13例,子痫8例);中度妊高征17例,其中合并心脏病2例,前置胎盘2例,胎盘早剥2例,重度贫血5例.

卵巢妊娠是异位妊娠中罕见的一种类型,近年来随着异位妊娠发病率的上升,卵巢妊娠的发病率也有明显的增加趋势。我院从1987年1月至1997年12月共收治14例卵巢妊娠,均经临床与病理证实,现报道如下。 临床资料 我院1987年1月至1997年12月共收治异位妊娠345例,其中卵巢妊娠14例,约占异位妊娠的4％,年龄26～37岁,平均年龄29.2岁。8例经产妇中4例宫内有节育器,6例有人工流产史。

目的观察康泉、灭吐灵、地塞本松联合应用时18例卵巢癌40人次以顺铂为主的联合化疗所产生的恶心、呕吐作预防性治疗。方法康泉3mg溶于生理盐水40ml缓慢静注、灭吐灵10mg、地塞米松5mg肌注，半小时后开始化疗，化疗结束后半小时重复使用后两种药。24小时记录恶心、呕吐次数及程度、连续7天。结果O度：22人次，I度：15人次，止吐有效率92．5％（37／40）。急性呕吐有效率92．5％（37／40），延迟期呕吐有效率95％（38／40）均高于文献报导的单独用康泉或灭吐灵止吐有效率。结论康泉、灭吐灵、地塞米松联合镇吐有效可行，且用量小，副作用少。