Objective:To evaluate effects of paraffin therapy on rehabilitation of hand function in patients with hemiplegia after stroke. Methods:Forty patients with post-stroke hand function loss were randomly assigned to study group and control group (20 ca-ses, respectively) . All participants received physical therapy and occupational therapy, while the study group was combined with par-affin therapy. Modified Ashworth scale ( MAS) , active range of movement ( AROM) of wrist and Fugl-Meyer assessment ( FMA) of hand function were used to assess the efficacies of the two groups. The spasticity and hand function were observed in two groups. Re-sults:The study group was superior to the control group in the spasticity and wrist functions (P<0. 01). The scores of FMA in the two groups were improved after the therapy (P<0. 05), but there was no significantly difference between the two groups (P>0. 05). Con-clusions:The paraffin therapy combined with conventional rehabilitation exercises can improve the hand recovery in the patients with hemiplegia after stroke.

Objective:To explore the efficacy and safety of Aripiprazole in the treatment of depression.Methods:Sixty patients were randomly devided into the study group(n=30) treated with escitalopram combined with Aripiprozole and the control group(n=30) treated with Escitalopram for 8 weeks.Hamilton Depression scale(HAMD) and Treatment Emergent Sympton scale(TESS) were used to evaluate the efficacy and side-effect respectively before and after treatment for 2,4 and 8 weeks.Results:The scores of HAMD were decreased significantly in study group at the end of 2 weeks while in control group at the end of 4 weeks.The score of HAMD in both groups were lower significantly than that before treatment(P0.01) and no significant difference of side-effect in both groups(P0.05).Conclusion:Escitalopram combined with Aripiprazole in the treatment of depression has better efficacy,takes effect quickly and with light side-effect.

Objective To explore the effect of fluvastatin alone and combined with aldosterone antagonist(antisterone)on expression of ICAM-1,VCAM-1 and MMP-9 of carotid in rabbits.Methods A rabbit model was established with high-lipid diet.96 New Zealand rabbits were divided into 4 groups :control,high-lipid diet,fluvastatin alone,and fluvastatin combined with aldosterone(n=24 in each group).The expressions of intercellular adhesion molecule-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1)and matrix metalloproteinase-9(MMP-9)were detected by immunohistochemistry.Results Expressions of ICAM-1,VCAM-1 and MMP-9 in the fluvastatin alone group and the combined group reduced gradually as the time went by(P0.05),and those expressions decreased significantly at 8 and 12 weeks(P0.05).Conclusion With the prolonged time of high-lipid feeding,the expressions of ICAM-1,VCAM-1 and MMP-9 increase in carotid tissue.Statins may delay artherosclerosis through decreased expressions of ICAM-1,VCAM-1 and MMP-9.This effect may be enhanced with the combination of aldosterone antagonist.

Objective:To explore the efficacy and safety of Mirtazapine and Citalopram combined with Zaleplon in the treatment of senile depression whose main complain was insomnia. Methods : 62 senile depressions were randomly divided into two groups, the Mirtazapine group and Citalopram combined with Zaleplon, for six weeks observation. Hamilton depression scale (HAMD) , Sleep disorder factor of HAMD and Pittsburgh sleep quality index (PSQI) were evaluated for clinical efficacy of improving insomnia, and treatment emergent scale (TESS) for side effect. Results: The remission rate was 83.9% for the Mirtazpine group and was 87.1% for Citalopram group respectively. There were no significant differences between the two groups in HAMD, sleep disorder factor of HAMD and PSQI at the end of week4,6 ( p > 0.05 ). The total incidence rate of side effects in Citalopram group combined with Zalepon was lower. Conclusions: Mirtazapine, as well as Citaloprum combined with Zalepon, was well efficient in the treatment of senile depression. However, Citalopram combined with Zalepon had few side effects such as hypersomnia. It could be the first - line of preferred ant depression in the treatment of elderly depression.

我们对利培酮(商品名:维思通)和阿立哌唑(商品名:博思清)治疗精神分裂症的疗效及安全性进行对照研究,现报告如下. 1对象和方法

120例抑郁症患者随机分为两组各60例。研究组给予帕罗西汀联合奥氮平治疗,对照组只给帕罗西汀治疗;帕罗西汀20~30 mg/d,奥氮平1.25~5 mg/d,共6周。采用汉密尔顿抑郁量表(HAMD)、不良反应量表(TESS)评定疗效及不良反应。经6周治疗,两组总有效率相近,但研究组在治疗后第2、4周末HAMD评分率明显低于对照组(P<0.05),TESS各周差异无统计学意义(P>0.05)。认为帕罗西汀联合奥氮平治疗抑郁症可以更快地消除抑郁症状,改善睡眠,缩短起效时间,提高治疗的依从性,不良反应并没有明显增加。

目的 探讨围绝经期综合征患者血清白细胞介素石(IL-6)、肿瘤坏死因子-α(TNF-α)水平及其与临床症状、生殖激素之间的相互关系.方法 测定血清IL-6、TNF-α、生殖激素水平,对42例围绝经期综合征患者(研究组)与26例处于围绝经期无症状者(对照组)进行对照及相关分析.结果 研究组治疗前后IL-6[(51.07±9.33)μg/L,(38.29±9.44)μg/L]、TNF-α[(67.55±7.34)μg/L,(48.74±8.90)μg/L]自身对照均差异有显著性(P＜0.05);治疗前与治疗后第6周研究组IL-6、TNF-α分别高于对照组[(32.85±7.59)μg/L,(38.27±10.15)μg/L],差异有显著性(P＜0.05);研究组IL-6、TNF-α与改良的Kupperman分值、抑郁、失眠、肌肉关节痛、疲倦乏力因子分呈显著正相关,其中IL-6与易激动、潮热出汗因子分呈显著正相关,而TNF-α与感觉异常、皮肤蚁走感因子分呈显著正相关;研究组治疗前雌激素(E2)浓度与IL-6、TNF-α呈负相关,治疗后促卵泡生成素(FSH)浓度与IL-6、TNF-α呈正相关.结论 围绝经期综合征存在免疫激活作用,IL-6、TNF-α水平与围绝经期症状、生殖激素之间密切相关。

本文综述了近年来慢性胃炎的临床、病理生理及治疗学研究进展.其临床特征更多地倾向于躯体形式障碍,尝试采用了抗抑郁、抗焦虑的药物取得了良好的疗效.提出了作为消化科医生应该掌握对慢性胃炎的精神科治疗.