目的:探究寻常痤疮皮损炎症程度与外周血白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平的相关性.方法:将113例寻常痤疮患者根据炎症程度分为轻度组(n=42)、中度组(n=39)和重度组(n=32),并选取同期113名健康者为对照组.比较两组IL-8、TNF-α水平、皮损数目,分析皮损炎症程度与外周血IL-8、TNF-α水平的相关性.结果:治疗前,寻常痤疮组IL-8、TNF-α水平均高于对照组(P<0.05);治疗后,患者血清IL-8、TNF-α表达水平均下降(P<0.05);治疗前及治疗14 d后,轻度组患者IL-8、TNF-α均低于中度组及重度组患者(P<0.05),中度组患者IL-8、TNF-α均低于重度组患者(P<0.05),各组治疗14 d后IL-8、TNF-α表达水平均低于治疗前(P<0.05);寻常痤疮组血清IL-8、TNF-α水平与炎症程度正相关(P<0.05);寻常痤疮组IL-8、TNF-α水平与炎性皮损数量正相关(P<0.05).结论:寻常痤疮患者IL-8、TNF-α表达水平与寻常痤疮皮损炎症程度正相关,检测患者外周血IL-8、TNF-α有助于诊断疾病、判断病情和预后.

目的 探讨鲍温样丘疹病(Bowenold papulosis,BP)患者组织中过氧化物酶体增殖物激活受体-γ(Peroxi-some proliferators activate receptors-γ,PPAR-γ)、环氧化酶2(Cyclooxygenase 2,COX-2)的表达情况及其相关性.方法 选择2020年1月至2021年11月期间秦皇岛市第一医院皮肤性病科活检的45例外阴病变皮肤组织作为观察组,另外选择于同期接受检查的40例正常外阴病变皮肤组织作为对照组.采用SP法对PPAR-γ、COX-2表达情况进行检测分析,并对二者相关性进行分析.结果(1)观察组组织中PPAR-γ表达评分与阳性率为(2.12±0.57)分与66.67％均分别显著高于对照组[(分别为1.03±0.34)分与17.50％](P均<0.05);(2)观察组组织中COX-2表达评分与阳性率分别为(2.49±0.65)分与71.11％,均分别显著高于对照组[分别为(0.95±0.18)分与7.50％](P均<0.05);(3)PPAR-γ与COX-2在BP组织阳性表达呈正相关性(P<0.05),但是在正常组织中的表达二者不呈相关性(P>0.05).结论 BP组织中PPAR-γ、COX-2均呈过表达特点,且二者在BP组织中的表达情况呈显著的正相关性.

目的 分析人乳头瘤病毒(HPV)感染所致鲍温样丘疹病(BP)患者L1-IgG抗体、存活素(Survivin)表达水平,为鲍温样丘疹病有效防治提供科学依据.方法 选取2019年1月—2022年1月秦皇岛市第一医院收治的HPV感染致BP患者150例.根据HPV分型分为高危型组112例和非高危型组38例.采用酶联免疫吸附法检测血清HPV L1-IgG抗体、Survivin、免疫球蛋白IgA、IgG、IgM、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)和干扰素-γ(IFN-γ)水平;采用流式细胞术检测患者外周血CD3+、CD4+、CD8+和CD4+/CD8+水平;使用杂交信号方法核酸检测技术,检测标本中HPV E6/E7 mRNA数量;Spearman相关性分析HPV E6/E7 mRNA和L1-IgG抗体、Survivin阳性表达水平关系.结果 高危型组和非高危型组患者 L1-IgG和Survivin 阳性表达分别为 73.21％(82/112)、67.86％(76/112)和26.32％(10/38)、31.58％(12/38),差异均有统计学意义(x2=26.314,15.400,P＜0.01).高危型组患者HPV E6/E7 mRNA 为(1 125.64±113.42)cop-ies/mL,且L1-IgG、Survivin阳性表达HPVE6/E7mRNA水平较高,呈正相关(P＜0.05).高危型组和非高危型组患者IgA、IgG、IgM分别为(1.23±0.13)、(8.89±0.91)、(1.13±0.12)g/L和(1.60±0.17)、(11.42±1.15)、(1.53±0.16)g/L,高危型组较低,差异均有统计学意义(t=13.971,13.814,16.246,P＜0.05).高危型组和非高危型组患者患者CD3+、CD4+分别为(58.78±5.91)％、(29.96±3.12)％和(65.48±6.61)％、(65.48±6.61)％,高危型组较低,差异均有统计学意义(t=5.858,8.249,P＜0.01).两组患者CD8+和CD4+/CD8+水平比较,差异无统计学意义(P＞0.05).高危型组患者TNF-α、IFN-γ和IL-6水平分别为(2.64±0.30)、(4.36±0.53)和(3.11±0.32)pg/mL,高于非高危型组患者(1.67±0.18)、(2.44±0.25)和(2.21±0.25)pg/mL,差异均有统计学意义(t=8.792,21.499,15.769,P＜0.05).结论 BP患者感染HPV可影响患者免疫调节功能和炎症反应,且HPV高危型患者L1-IgG抗体和Survivin阳性表达水平高于非高危型组患者.

Objective To explore the psychological and sleep quality of 120 cases of severe acne students in Qinhuangdao City.Methods 120 cases from July 2013 to July 2016 in our hospital department of Dermatology, medical college students and trainee medical students as the research object were the observation group, patients with severe acne, in the same period to acne free medical students as a control group of 60 cases in our hospital department of Dermatology trainee object, a detailed record of severe acne and acne students the students of clinical data the calculation, all patients and no acne students SAS, SDS, PSQI and SCL-90 scores, analysis and comparison. Results The anxiety rate was 78.33% in the severe acne patients, and the moderate anxiety and anxiety rate were 45.00% in the control group, and the difference was statistically significant (P<0.05). The depression rate was 65.00% in the patients with severe acne and 43.33% in the control group. There was significant difference between the two groups (P<0.05).The scores of PSQI in patients with severe acne were significantly higher than those of normal acne students, and the quality of sleep was poor. There was significant difference between the two groups (P<0.05). Patients with severe acne were significantly higher in interpersonal relationships, depression, anxiety, hostility, paranoid and SCL-90 scores than those without normal acne, and the two groups were statistically significant (P<0.05). Conclusion Severe acne students are more prone to anxiety, depression and other negative emotions, more psychological disorders, adverse mood and affect the quality of sleep, increase acne, seriously hinder the patient learning, work and life, reduce the quality of life.

ObjectiveTo study the effect of mental intervention in the treatment of severe acne.Methods Stratified cluster sampling was used to investigate medical students in Hebei Medical University, and iffty-two cases with severe acne vulgaris were divided into control group and observation group randomly, 26 cases in each group. The patients in two groups were treated with Shugan Jieyu capsule and Isotretinoin soft capsule. And the patients in observation group were given with mental nursing. After 3 months, the clinical efifcacy of the two groups was compared. And the scores of Dermatology life quality index (DLQI), Self-rating depression scale (SDS), Self-rating anxiety scale (SAS) and Medical coping modes questionnaire (MCMQ) were compared between the two groups. Results The morbidity rate on acne vulgaris of medical students in Hebei Medical University was 35.88%, and the rate for male was signiifcantly higher than female, the difference was statistically signiifcant (P<0.05). The observation group DLQI, SAS, SDS and MCMQ yield scores were signiifcantly lower than the control group (P<0.05), however, the meet score for MCMQ of observation group were signiifcantly higher than those of control group(P<0.05).Conclusion The application of mental intervention in the treatment of severe acne can help relieve the patient's self-perceived burden, relieve anxiety and depression, and improve the quality of life. It has positive signiifcance for the recovery of the disease.

激素依赖性皮炎又称糖皮质激素瘾性皮炎或局部糖皮质激素戒断皮炎，面部激素依赖性皮炎是其中临床上最常见的类型，是不正当使用皮质类固醇激素或在某些化妆品使用过程中所发生的局部面部非感染性炎症性皮肤病。目前，面部激素依赖性皮炎的发病率逐年升高，其主要表现为皮肤灼热、瘙痒、干燥、刺痛、脱屑及皮肤紧绷感，伴有红斑潮红、肿胀渗出、炎性丘疹、脓疱、毛细血管扩张、皮肤萎缩、毳毛增生、皮肤色素沉着等。临床上一般以停用激素、心理疏导、局部保湿抗炎治疗，该治疗短期效果尚可，但停止治疗后远期效果欠佳。2010-01-2013-01，我们应用重组人表皮生长因子凝胶、复方甘草酸苷联合中药汤剂治疗面部激素依赖性皮炎71例，并与单纯复方甘草酸苷治疗71例对照观察，结果如下。

面部激素依赖性皮炎是长期不正当使用皮质类固醇激素及在某些化妆品使用过程中所发生的常见的、难治的局部皮肤病。实际临床工作中我们发现，其特征是激素依赖，主要表现是皮肤出现红斑、肿胀渗出、炎性丘疹、脱屑、萎缩、毳毛增生及灼热、瘙痒、干燥、刺痛等不良反应。临床上面部激素依赖性皮炎发病率逐年增多，已成为发生于面部的常见皮肤病，并且严重影响了患者的工作、生活和学习。为了更多地了解面部激素依赖性皮炎中医辨证证型、发病病程和性别与蠕形螨检测结果的相关性，我院皮肤科对80例已经确诊为面部激素依赖性皮炎患者进行了观察研究，结果如下。