The N-acetyl-carnosine eye drops were prepared,and was stable at room temperature for 2 years. No eye irritation was observed by the eye drops with rabbits as the animal models.Pharmacodynamic experiments of rat cataract induced by sodium selenite demonstrated that the eye drops could delay the development of lens turbidity, enhance superoxide dismutase,catalase,glutathione peroxidase activities and decrease malondialdehyde and infusible protein content of lenses.The effect of the middle dosage of the eye drops was comparable to the two positive control drugs pirenoxine sodium and bendazac lysine eye drops.

In vitro release of enteric capsules of Poecilobdella manillensis Lesson extract using sodium carboxy-methyl starch as disintegrant was investigated. The remained biological activities of capsules dissolving in 0. 1mol/L HCl with or without pepsin for 2h were examined. The results showed that the enteric capsules could protect the extract from destroying by acid and pepsin. The results of preliminary stability test showed that the capsules stored at 25℃, 60%RH for 6 months had little change of biological activities including antithrombin activity, anti-trypsin activity and anti-alfapsin activity, and the accumulative release (%) in 45min in pH 6.8 phosphate buffer solution were still above 15%.

AIM: To provide scientific references for leeches by means of the antithrombin,antitrypsin and antichymotrypsin activities of the four kinds of leeches. METHODS: Using antithrombin,antitrypsin and antichymotrypsin activity analysis methods,the four kinds of leeches,they were,Whitmania pigra Whitman,Hirudo nipponia Whitman,Hirudo medicinalis Linnaeus,Hirudinaria manillensis Lesson,were detected. RESULTS: The blood-sucking leeches except whitnania pigra whitman had high antithrombin activity,and these four kinds of leeches were the same antitrypsin and antichymotrypsin activities. CONCLUSION: These three biological activity methods could be considered as reliable indexes in assessing the qualitity of leeches.

研制了中药穴位经皮给药系统——止咳平喘膜剂。采用双室渗 透扩散装置考察膜剂的经皮吸收性能; 测定膜剂于小鼠膻中、肺腧等穴位用药后的穴位电阻 值、Na+-K+-ATP酶活性和经皮吸收量。结果表明，膜剂中有效成分之一的黄芩甙以零 级速率透过皮肤,渗透性能良好;穴位给药后皮肤电阻值降低，酶活性升高，经皮吸收量增加 ,与非穴位给药相比有显著性差异。