Objective:To discuss the effects of chronic anger stress on rats' brain aging progress and concentration of plasma monoamine neurotransmitters.Methods:Induced anger stimulation after building D-gal aging and brain aging model,we observed the effects of chronic anger stress on the spatial learning and memory of rats by Morris water maze,and measured the contents of plasma monoamine neurotransmitters:norepinephrine(NE),5-hydroxytryp-tamine(5-HT),dopamine(DA).Results:Compared with the model group,the rats' spatial learning and memory in the angry stress group decreased obviously,the contents of NE and DA in plasma in the angry stress group increased,the contents of 5-HT decreased.Conclusion:The rats' brain aging was aggravated by chronic anger stress,the aging was accelerated;the rat's monoamine neurotransmitters disorder may be one of the mechanisms.

目的：探讨慢性愤怒应激对大鼠脑老化进程及血浆儿茶酚胺水平的影响。方法：在D-半乳糖（D-gal）衰老及脑老化模型基础上引入愤怒刺激，用Morris水迷宫实验观察慢性愤怒应激对大鼠空间学习记忆能力的影响，并测定血浆中儿茶酚胺肾上腺素（E）、去甲肾上腺素（NE）、多巴胺（DA）的含量。结果：与模型组比较，愤怒应激组大鼠空间学习记忆能力明显下降，血浆E、NE、DA均显著升高。结论：慢性愤怒应激加重D-gal大鼠脑老化程度，加速衰老进程；血浆儿茶酚胺含量升高可能是其发生的机制之一。

Objective To investigate whether anger emotion is the risk factor of Alzheimer′s disease(AD),and for the long-term accumulation of anger can accelerate the aging brain to provide epidemiological basis.Methods AD patients were selected as case groups,the controls without dementia,depression,a history of neurological or psychiatric illness were selected as normal control groups in hospital or community,according to the same sex,same age(± 3 years),and the same educational level,proceeded 1∶1 matched the case-control study.Survey method was face to face interviews.Results Trait anger of AD patients scored significantly higher than that of normal control group(P<0.01).Compared with normal control group, high trait anger individuals risk of AD was significantly higher than that of low trait anger individuals(P<0.01).The OR value(95%CI) was 51.857(14.009,191.954).AD patients with anger expression(AX-O,AX-I) was significantly higher than that of normal control group(P<0.01),and anger control(AC-O,ACI) was significantly lower than that of normal control group(P<0.01),AD patients with anger expression index was significantly higher than that of normal control group(P<0.01).Conclusions Anger emotion is associated with AD,high trait anger is the risk factor of AD.AD patients are more likely to tendency or character of anger expression-out or anger expression-in,they have the high level of anger expression and low controlled anger.

目的探讨阿尔茨海默病（AD）的危险因素,初步分析愤怒情志与AD的关系。方法选取AD患者作为病例,以医院、社区无痴呆病及抑郁症等神经或精神疾病史者为对照,按同性别、同年龄段（±3岁）、同文化程度进行1∶1匹配的病例对照研究。调查方式为面对面访谈。结果单因素分析结果显示,健身锻炼、娱乐活动、家庭和睦、人际关系、AD家族史、脑外伤史、特质怒与AD有统计学关联（P＜0.05）。而吸烟、饮酒、负性生活事件、既往心脑血管病史、既往职业接触史与AD无统计学关联（P＞0.05）。多因素分析结果显示,高特质怒、AD家族史、健身锻炼和娱乐活动与AD有统计学关联（P＜0.05）。结论高特质怒、AD家族史是AD的危险因素,健身锻炼和娱乐活动是AD的保护因素。愤怒情志与AD密切相关,频繁发怒或郁怒等慢性愤怒应激是诱发AD的原因之一。

<正>近世尚补,以参为重,或膳或酒,须参为主,谓其久服轻身祛病延年,殊不知人参泛种而药效大减,洋参移栽速成而禀性悄变。尝观北美所产,参须皱枯相拥甚紧。遍视国内移栽,多肥硕肿满,恐失其原旨,而此尚未虑及炮制诸法及以桔梗等等混充事者。