目的:研究上调Notch胞内区域(Notch Intracellular Domain,NICD)对人牙周膜干细胞增殖及迁移能力的影响.方法:将细胞分为上调组、对照组及空白组,使用MTT比色法检测细胞增殖能力,流式细胞仪检测细胞凋亡能力,采用细胞划痕实验检测细胞迁移情况,并使用Western blot检测人牙周膜干细胞中Wnt/β-catenin信号通路蛋白(TGF-β、BMP-2、β-caten、LEF-1、Cyclin D1、Caspase-3、Bax、Bcl-2)表达量.结果:对照组各时间点的人牙周膜干细胞增殖率、碱性磷酸酶活性、迁移、黏附个数、TGF-β、BMP-2、β-caten、LEF-1、Cyclin D1、Bcl-2蛋白表达量均低于空白组,且凋亡率、Caspase-3、Bax蛋白表达量高于空白组,差异具有统计学意义(P<0.05).上调组各时间点人牙周膜干细胞增殖率、碱性磷酸酶活性、迁移、黏附个数、TGF-β、BMP-2、β-caten、LEF-1、Cyclin D1、Bcl-2蛋白表达量均高于空白组和对照组,且凋亡率、Caspase-3、Bax蛋白表达量均低于空白组和对照组,差异具有统计学意义(P<0.05).结论:上调NICD基因能促进人牙周膜干细胞的增殖和迁移,其机制可能与Wnt/β-catenin通路有关.

目的 探讨恒牙列骨性Ⅱ类错牙合拔牙矫治后牙弓形态、颊廊及侧貌的变化情况及其相关性,为骨性Ⅱ类错牙合拔牙矫治提供参考.方法 选取2013-01～2017-12在广西壮族自治区人民医院口腔正畸科接受拔牙矫治的恒牙列骨性Ⅱ类错牙合患者15例,应用X线头影测量技术分析矫治前后患者牙颌颅面结构变化,游标卡尺测量矫治前后上颌模型牙弓长度、宽度的变化,Adobe Photoshop CS6软件测量分析矫治前后患者正面微笑像变化.分析矫治前后颅颌牙面软硬组织,牙弓宽度、长度以及正面微笑像颊廊相关指标的变化情况及相关性.结果 矫治后,患者SNA角、ANB角、U1-NA角、UL-E和LL-E较治疗前降低,NLA角较治疗前增加,差异有统计学意义(P＜0.05);上颌牙弓中段宽度(UPP)、上颌牙弓后段长度(UPD)、上颌牙弓后段宽度(UMM)和上牙弓全段长度(UAD+UPD)指标均减小,与治疗前比较差异有统计学意义(P＜0.05).与治疗前比较,矫治后正面微笑像口角宽度(Ch to Ch)、正面微笑像颊廊宽度之和(BC)及正面微笑像双侧颊廊比率(BCR)水平增加,正面微笑像上颌可见牙列宽度(Va to Va)水平降低,但治疗前后比较差异均无统计学意义(P＞0.05).Pearson相关分析结果显示,UPP变化与BC和BCR变化呈负相关(P＜0.05);UAD+UPD变化与UL-E变化呈正相关(P＜0.05);Ch to Ch变化与U1-NA和UL-E变化呈负相关(P＜0.05);BC变化与SNB角呈正相关(P＜0.05).结论 骨性Ⅱ类错牙合拔牙矫治后牙弓长度变化与侧貌凸度改善密切相关,牙弓中段宽度减少可能会引起正面微笑时颊廊增加.

Objective To investigate the changes in the sagittal diameter of the upper airway before and after the treatment of skeletal Class Ⅲ malocclusion in adults with microimplant anchorage and class Ⅲ intermaxillary elastics and to provide a reference for clinical treatment. Methods A total of 35 adult patients with skeletal Class Ⅲ malocclusion were selected to be treated with the straight-wire technique. Microimplant group, 15 cases (group A): patients with severe skeletal Class Ⅲ malocclusion (vertical high angle) were treated with the straight-wire technique combined with microimplant anchorage; class Ⅲ intermaxillary elastics group, 20 cases (group B): Patients with mild or moderate skeletal Class Ⅲ malocclusion (vertical low angle and average angle) were treated with the straight-wire technique combined with class Ⅲ intermaxillary elastics, and cephalometric radiographs obtained before and after treatment in the upper airway in the two groups were measured and analyzed. Results Changes in cranial and maxillofacial measurements after correction: in group A, (sella-nasion-supramental angle) the SNB angle decreased significantly (P < 0.05), and (subspinale-nasion-supramental angle) the ANB angle increased significantly (P < 0.05). In group B, the SNB angle decreased significantly (P < 0.05), while (subspinale-nasion-subspinale angle) the SNA angle、ANB angle and anterior skull base plane-mandibular plane angle (Sn-MP) angle increased significantly (P < 0.05). Changes in sagittal diameter of the upper airway measurements after corrections: In group A, the width of the glossopharyngeal segment of the upper airway (TB-TPPW) decreased significantly (P < 0.05). In group B, first segment width of the upper airway behind the hard palate (PNS-R) increased significantly (P < 0.05). After correction, the decreased SNB and increased ANB in group A was higher than that in group B, and the difference was statistically significant （P < 0.05）. The decreased of TB-TPPW in upper airway of group A was greater than that of group B, and the difference was statistically significant （P < 0.05）. Conclusions In the treatment of skeletal class Ⅲ malocclusion with microimplant anchorage, the sagittal diameter of the glossopharyngeal segment of the upper airway has a negative impact.

目的 构建包含不对称摇椅弓的上颌矫治系统三维非线性有限元模型,为探讨不对称摇椅弓作用于牙列的生物力学机理奠定基础.方法 利用上颌骨及上牙列等CT扫描数据及托槽弓丝等实体数据,通过运行三维有限元分析等专用软件,建立包含上颌骨、牙列、托槽、不对称摇椅弓等在内的整体上颌三维非线性有限元模型.结果 建立了含不对称摇椅弓的上颌三维非线性有限元模型,包含160514个单元和242878个节点.结论 建立的有限元模型具有较高的仿真度和良好的几何相似性,为进一步探讨不对称摇椅弓矫治牙合平面偏斜时作用于牙列的力学机理提供了良好的研究手段.

目的 了解恒牙列骨性Ⅲ类错(牙各)患者单纯正畸掩饰性治疗前后(牙各)平面、下颌平面的变化及其相关关系.方法 回顾性分析12例恒牙列骨性Ⅲ类错(牙各)患者的临床资料,其中ANB角平均(-3.33±1.74)°,SN-MP角平均(37.67 ±4.89)°.拔下颌左右第二或第三恒磨牙,配合下颌颊棚区微种植体支抗或多曲方丝弓技术矫治,比较矫治前后X线头影测量指标变化情况,分析矫治前后牙颌颅面变化与(牙各)平面、下颌平面变化的相关关系.结果 矫治后ANB角平均增大(1.79±1.62)°;OPP-FH平均减小(2.83±2.92)°,FH-OP平均减小了(2.25±2.13)°,矫治前后比较差异有统计学意义(P＜0.05);OPA-OPP、FH-MP、SN-MP矫治前后比较差异无统计学意义(P＞0.05).相关分析结果显示,前面高、前下面高变化与下颌平面变化之间存在正相关关系(P＜0.05).结论 恒牙列骨性Ⅲ类错(牙各)患者经过合理的支抗设计,可以得到良好的矫治,患者正侧貌也可一定程度改善,(牙各)平面及下颌平面也可以得到较好控制.

目的 探讨Ⅱ类高角骨面型患者拔牙矫治后颅颌牙面变化与软组织侧貌改善的相关性.方法 选取22例Ⅱ类高角骨面型成人患者治疗前后的X线头颅侧位片,用头影测量法比较治疗前后的骨组织、牙组织变化以及软组织变化,并分析软硬组织变化的相关性.结果 矫治后,上、下前牙分别内收了7.55 mm和3.05 mm,上、下唇相对E平面突度分别减小3.02 mm和2.74 mm,面凸角、Z角和鼻唇角分别增加2.39°、3.72°和8.11°,变化差异均有统计学意义(P＜0.05).面凸角变化与软组织颏前点突度变化呈正相关(r=0.411,P＜0.05),与下切牙唇倾斜度变化呈负相关(r=-0.402,P＜0.05);Z角变化与上切牙唇倾斜度变化、上唇突度变化及下唇突度变化呈负相关(r=-0.414、-0.421、-0.435,P＜0.05);鼻唇角变化与上切牙突度变化、上唇突度变化、上切牙唇倾斜度变化和下切牙唇倾斜度变化呈负相关(r=-0.542、-0.388、-0.516、-0.400,P＜0.05).结论 Ⅱ类高角骨面型成人患者拔牙矫治后,切牙大幅内收,鼻唇颏关系趋于协调.侧貌改善与上下切牙内收、上下唇突度变化存在中度相关性.

BACKGROUND: Lingual bracket system is the best invisible orthodontic appliance due to its aesthetics and efficiency, but it is difficult to control anterior tooth torque during the distal retraction of the anterior tooth. Thereafter, lots of studies on maxillary anterior teeth have been conducted, but there is less knowledge about the mechanical characteristics of whole mandible dentition distal retaction. OBJECTIVE: To analyze the biomechanical characteristics of the mandibular anterior teeth distal retracted by sliding method in lingual orthodontic treatment. METHODS: A three-dimensional finite element model was constructed using a series of specialized software based on volunteer's CT data and lingual brackets, including the mandible, alveolar bone, periodontal ligament, dentition (removal of the two first premolars), lingual brackets and arch wire with hooks (located between lateral incisor and canine and 11 mm distant from the arch wire plane). Subsequently, 1.5 N lingual forces through the hooks of first molar (2 mm distant from the arch wire plane) and the hooks between the lower lateral incisor and canine were loaded and the biomechanical characteristics of the mandibular anterior teeth movement during the en-masse retraction were analyzed. RESULTS AND CONCLUSION: The finite element model was constructed successfully, and had a higher geometrical similarity and resemblance of clinical situation. The crowns of lower incisors showed the tendency of lingual inclination and extension, and this tendency was more obvious in the lateral incisors. The canines were buccal and mesial inclination and intrusion. The periodontal stress concentration area was corresponded with the tendency of tooth movement. Therefore, the movement tendency of incisors is still lingual inclination when mandibular anterior teeth distal retracted by a longer hook in lingual brackets system, and there is no distal inclination. Overall, lower incisors are easy to exhibit lingual inclination; the long anterior hooks contribute to the movement of canines, but it is not available for the vertical control of incisors during mandibular anterior tooth distal retraction.

目的:分析舌侧矫治技术不同长度牵引钩条件下,滑动法整体内收上前牙时牙移动的生物力学特征.方法:利用所建立的舌侧矫治技术内收上前牙三维有限元模型,分别于上前牙区牵引钩(长度2～10 mm)和腭侧的微种植钉间加力1.5 N,内收上颌前牙并分析其牙列位移趋势.结果:牵引钩长度在4 mm以内时,均表现为上颌切牙牙冠的腭侧移动趋势,从6 mm开始,中切牙和尖牙牙冠出现唇侧移动趋势,并随牵引钩加长唇倾越明显.结论:随着牵引钩的加长,前牙牙冠的腭侧倾斜移动趋势减小,长牵引钩可能更有利于上前牙的整体内收移动.

目的 探讨牙周干预对2型糖尿病伴牙周病患者口腔健康状况和血糖控制的影响.方法 将146例糖尿病伴牙周病患者随机分为实验组(75例)和对照组(71例).对照组进行口腔卫生宣教、正确刷牙方法指导及发放口腔保健用品.实验组在对照组的基础上还进行龈上洁治术和(或)龈下刮治术等牙周干预治疗.比较两组干预前后牙周指数、龈下菌斑中牙龈卟啉单胞菌含量、空腹血糖(FBG)和糖化血红蛋白(HbA1c)水平变化情况.结果 (1)两组不同阶段牙周指数的比较:3个月及6个月时实验组牙周指数均较前一阶段下降,对照组均较前一阶段上升,两组差异有统计学意义(P＜0.05);12个月时两组牙周指数均较6个月时上升,差异有统计学意义(P＜0.05).(2)两组不同阶段龈下菌斑Pg检出量比较:3个月时实验组龈下菌斑中Pg检出量较基线值下降,对照组较基线值上升,两组差异有统计学意义(P＜0.05);6个月及12个月时两组龈下菌斑Pg检出量均较前一阶段上升,但差异无统计学意义(P＞0.05).(3)两组不同阶段FBG比较:3个月时实验组FBG较基线值下降,对照组较基线值上升,差异无统计学意义(P＞0.05);6个月时两组FBG均较3个月时上升,差异无统计学意义(P＞0.05);12个月时实验组FBG较6个月时下降,对照组较6个月时上升,但两组差异无统计学意义(P＞0.05).(4)两组不同阶段HbA1c比较:3个月时两组HbA1c均较基线值下降,差异无统计学意义(P＞0.05);6个月时实验组HbA1c较3个月时下降,对照组较3个月时上升,两组差异有统计学意义(P ＜0.05);12个月时实验组HbA1c较6个月时上升,对照组无明显变化,两组差异无统计学意义(P＞0.05).结论 牙周干预不仅可改善2型糖尿病伴牙周病患者的牙周状况,在糖尿病病情控制方面也起积极的作用;2型糖尿病伴牙周病患者牙周基础治疗需长期坚持,建议每半年定期进行一次口腔健康检查,应积极配合医师进行牙周综合干预.

BACKGROUND: Mandibular advancement devices are commonly used in patients with mild to moderate obstructive sleep apnea hypopnea syndrome. But wearing with mandibular protraction appliance makes the mandible in an abnormal position, and inevitably affects the temporomandibular joint (TMJ). As one of the important components of the TMJ, can structural changes of the joint disk impair the TMJ? Are there any differences in the TMJ structure between Angle Class Ⅰ and Class Ⅱ? What will happen to the TMJ structure in the Angle Class Ⅰ and Class Ⅱ during mandibular advancement? Is there a same law of TMJ changes for Angle Class Ⅰ and Class Ⅱ? All of these are undetermined systematically. OBJECTIVE: To compare the changes in the structure of TMJ disk and the differences during mandible advancement between Angle Class Ⅰ and Class Ⅱ adult males. METHODS: Forty non-apnea adult males were divided into two groups (n=20 per group), including Class Ⅰ and Class Ⅱ groups, according to the Angle's classification and sagittal skeletal facial type. Each volunteer was scanned by MRI in three positions, including central occlusion (F0), 75% of the maximum mandible advancement (F75) and maximum of the mandible advancement (F100). These indexes that were correlated with morphology of the joint disk in different mandible advancement positions were measured and calculated by MRI, and then analyzed statistically. RESULTS AND CONCLUSION: In F0, the ratio of disk anterior displacement in the Class Ⅱ group was higher than that in the Class Ⅰ group (P< 0.01). The angle A was decreased as the mandible advanced in both groups from F0to F75(P < 0.01). The rotational angular dimension was increased as the mandible advanced, and the sizes from F0to F100were bigger than those from F0to F75(P < 0.05). Some differences existed in the structure of TMJ disk between Angle Class Ⅰ and Ⅱ adult males. In summary, appropriate mandibular advancement may play a positive role in patients with anterior displacement of the joint disk, but excessive mandible advancement is likely to impair the TMJ disk.

目的 了解戴用下颌前移口腔矫治器后阻塞性睡眠呼吸暂停疾病(OSAD)患者的睡眠结构变化.方法 选取行下颌前移口腔矫治器治疗的OSAD患者61例,接受口腔矫治器治疗前后均行多导睡眠图检查.将患者分为治疗后成功组52例及不成功组9例,对两组治疗前后的睡眠分期比率及疗效进行比较.结果 成功组治疗前后S3、AI、HI、AHI、LSpO2、最长呼吸暂停时间比较差异有统计学意义(P＜0.05).不成功组治疗前后AHI、最长呼吸暂停时间比较差异有统计学意义(P＜0.05).两组治疗后呼吸参数AI、AHI、LSpO2比较差异有统计学意义(P＜0.05).结论 戴用下颌前移口腔矫治器治疗成功的OSAD患者深睡眠百分比略有增加.

目的 了解拔牙矫治及相关肌功能训练在改善恒牙列Ⅱ类骨面型患者正畸后微笑美中的作用.方法 20例恒牙期Ⅱ类骨面型患者,在拔牙设计,直丝弓矫治技术应用技术同时,配合相关微笑美肌功能训练.应用Adobe Photoshop CS7软件对矫治前后微笑相进行定点和测量(包括上前牙曲度、下唇曲度、颊廊、微笑宽度、微笑高度、上下前牙暴露量、微笑弧及上唇曲度形态等),应用SPSS17.0软件对矫治前后颅颌面结构及微笑相测量数据进行统计分析.结果 矫治后上前牙曲度增大,颊间隙比率和上切牙比率有所增加,下切牙暴露量减少,与矫治前比较差异有统计学意义(P＜0.05);矫治后理想笑弧和上唇曲度向上的例数明显增加,平坦笑弧和向下的上唇曲度例数明显减少,差异有统计学意义(P＜0.05);矫治后U1-SN角变化与上牙曲率变化呈负相关,SN-MP角变化与颊旁间隙比率变化呈负相关(P＜0.05).结论 恒牙列Ⅱ类骨面型患者拔牙矫治并配合微笑美肌功能训练各项微笑美指标矫治后均有所改善,其中颊廊与面下1/3高度相关,笑弧与上前牙唇倾度高度相关.

目的 探讨应用MRC肌功能矫治器治疗口腔不良习惯并伴有错(牙合)畸形患儿的矫治效果.方法 将2011-03 ～ 2014-03到该院就诊的患儿按就诊单双日随机分为试验组(13例)和对照组(12例),试验组选择合适的软质MRC肌功能矫治器(以Infant型为主)对患儿进行矫治;对照组采用传统的功能性矫治器进行矫治.比较两组矫治口腔不良习惯效果,同时比较两组家长对矫治器佩戴的舒适度、矫治效果的主观评价.结果 试验组矫治口腔不良习惯效果的成功率高于对照组,但差异无统计学意义(P＞0.05).试验组第1周、1个月、3个月佩戴顺利率高于对照组,差异有统计学意义(P＜0.05).结论 MRC肌功能矫治器能较好地矫治儿童口腔不良习惯,且具有轻便、无损坏、造价低、技术敏感度低等优点,值得临床推广应用.

Objective The aim of this article is to study the changes of dental and base bone arch after non-extraction orthodontic treatment in subjects with skeletal ClassⅢ malocclusion.MethodsThe sample consisted of pre- and post-treatment models from 23 skeletal ClassⅢ malocclusion subjects who accepted non-extraction orthodontic treatment. The length and width of dental arch and basal bone arch in intercanine area, interpremolar area and inter-ifrst-molar area were measured, then analyzed the correlation between pre- and post-treatment group.Results① The dental length of the anterior maxillary arch(UAD) and the width of mandibular inter-first-molar (LMM) increased (P<0.05), while the dental width of maxillary intercanine(UCC),interpremolar (U1PP,U2PP) and mandibular intercanine(LCC) decreased (P<0.05) after treatment.② The length of maxillary basal bone (UBAL) increased(P<0.05), while mandibular basal bone length(LBAL) decreased (P<0.05) after treatment.③ A positive correlation was found between the changes of dental arch and base bone arch width and length, especially in mandibular canine area, ifrst molar area and maxillary ifrst molar area.ConclusionAfter non-extraction orthodontic treament of skeletal ClassⅢ malocclusion in permanent dentition, the compensatory changes of the dental arch can induce the adaptation of the corresponding regional base bone arch,which is beneift to the effect and stability of orthodontic treatment.

Objective To investigate the characteristics of anterior and posterior occlusal planes of adolescents with skeletal classⅡ malocclusion.Methods 158 cases in skeletal class Ⅱ malocclusion were selected,all the cases were divided into 3 groups according to different vertical skeletal types: the high,average and low angle groups.The measurement items of anterior and posterior occlusal planes and the items related to the craniofacial structures were marked and measured on the lateral cephalograms of patients by Winceph 8.0,and the measurements were analyzed statistically.Results Items of occlusal planes in both anterior and posterior occlusal plan inclination angles,Go-A angle and RAM-I angle of the high-angle group were larger than that of average and Low-angle groups,and the items of average angle group were larger than that of Low-angle group too(P<0.05).Conclusion There are some differences both in the anterior and posterior occlusal planes among adolescent skeletal class Ⅱmalocclusion patients with different vertical skeletal types.The anterior and posterior occlusal planes in high skeletal type are steeper than other vertical skeletal types,and the craniofacial structures have the corresponding characteristics.

[Objective]To study effect of pain and stress response of NiTi rotary instrument for children with root canal therapy , and analyzed possible mechanisms.[Methods]60 cases(60 teeth)children with Dental pulp disease or root tip disease by root canal therapy from March 2015 to March 2017 were divided into observation group and control group. The control group used Hand NiTi en-larging file,observation group used NiTi rotary instruments,then root canal preparation,stress response,pain,filling effect and long-term efficacy were compared between two groups.[Result]The observation group root canal preparation time were significantly shorter than control group(P < 0.01),root canal deviation etc morphological changes(6.67%)was significantly lower than control group(26.67%,P < 0.05);gingival crevicular fluid TNF-α,IL-6,IL-1β were significantly lower than control group(P < 0.05, P < 0.01). In root canal preparation,after root canal preparation,pain rate were significantly lower than control group(10.00% vs 33.33%,3.33% vs 23.33%,P < 0.05);1 week after surgery,just fill rate(93.33%)was significantly higher than control group (70.00%,P<0.05). Followed up 6 months,root canal success rate(90.00%)was significantly higher than control group(66.67%, P<0.05).[Conclusion]NiTi rotary instruments help to reduce the pain in children with root canal,improve clinical efficacy,May be related to inhibition of surgical stress response.

目的 了解2型糖尿病伴牙周病患者对口腔健康知识的认知情况以及口腔行为习惯.方法 选择2型糖尿病伴牙周病变患者191例作为调查对象,通过问卷调查了解患者口腔健康相关知识知晓情况和口腔行为情况.结果 除了"牙龈出血应及早就医"回答的正确率达到61.78%外,患者对口腔健康知识的知晓率均低于50.0%;除了"每天刷牙2次以上"和"进食后及时清洁口腔"的行为率达到93.19%和90.58%外,患者其他各项口腔健康行为率均低于90.0%;患者获得口腔保健知识的来源主要有口腔专业人员教育(25.6%)、广播电视(48.1%)、互联网、报纸和杂志(20.1%).结论 2型糖尿病伴牙周病患者对口腔健康知识的知晓率较低,大多数患者的口腔行为不健康,应加强口腔保健知识的健康教育,促进患者健康的口腔行为.

目的 观察护牙素对龈下刮治后牙本质敏感患者牙周指数的影响,探讨脱敏治疗对口腔卫生维护和疗效维护的影响.方法 将116例(464颗患牙)龈下刮治所致的牙本质敏感患者随机分为治疗组(60例,240颗患牙)和对照组(56例,224颗患牙),治疗组采用GC护牙素(日本株式会社而至齿科)进行脱敏治疗,对照组不进行任何脱敏治疗.观察治疗后1周、1个月的牙石指数(CI)和软垢指数(DI)的变化.结果 治疗后1周,对照组CI和DI值均较治疗组显著升高(P＜0.05),治疗后1个月,对照组CI和DI值均较治疗组显著升高(P＜0.05).结论 经护牙素脱敏治疗的牙周病患者更容易保持相对健康的牙周指数.

目的 评价护牙素治疗龈下刮治所致牙本质敏感的临床疗效,并探讨其作用机制.方法 将116例(464颗患牙)龈下刮治所致的牙本质敏感患者随机分为治疗组(60例,240颗患牙)和对照组(56例,224颗患牙),治疗组采用GC护牙素进行脱敏治疗,对照组不进行任何脱敏治疗.观察治疗后1周、1个月的VAS评分、CI值及DI值.结果 治疗后1周,治疗组的VAS值显著降低,与对照组比较,差异具有统计学意义(P<0.05).治疗后1个月,治疗组与对照组VAS值均降低,二者比较差异统计学意义(P>0.05).结论 GC护牙素在龈下刮治后早期可以起到缓解牙本质敏感的作用.

目的:评价短期应用100 g/L酪蛋白磷酸多肽钙磷复合体(Tooth Mousse护牙素)对鼻咽癌放射性龋预防的效果.方法:选择鼻咽癌初次放疗患者230例,口腔综合防治后随机分为4个实验组和1个对照组(n=46).对照组不用护牙素药池;实验1、2组用护牙素药池每天10 h各持续7、14 d;实验3、4组用护牙素药池每天20h以上各持续7、14 d.统计分析各实验组与对照组放疗前后患龋率和龋失补牙面数、牙髓/根尖周炎、残根的发生率等.结果:放疗前,各组患龋率、1年后新患龋率和龋失补牙面数、牙髓/根尖周炎、残根比较无统计学差异(P＞0.05),放疗后1年,各组以上指标均增加;4个实验组各项指标均低于放疗前(P＜0.05),各实验组间比较则无统计学差异(P＞0.05).结论:采用Tooth Mousse护牙素药池综合防治对放射性龋预防效果良好.